PDGFR

Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer. There are two forms of the PDGF-R, alpha and beta each encoded by a different gene. Depending on which growth factor is bound, PDGF-R homo- or heterodimerizes.

Cat. No.	Product name	CAS No.	Purity
T1621	Imatinib Mesylate	220127-57-1	99.73%
T1621	Imatinib Mesylate (STI-571) is a tyrosine kinase receptor inhibitor with antineoplastic activity (IC50s: 0.6 μM, 0.1 μM and 0.1 μM for v-Abl, c-Kit and PDGFR, re...
T2446	KI8751	228559-41-9	99.73%
T2446	KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.
T8482	Ripretinib	1442472-39-0	99.72%
T8482	Ripretinib (DCC-2618) is an orally bioavailable inhibitor of KIT and PDGFRA.
T7945	SU14813	627908-92-3	99.72%
T7945	SU14813 is a multi-receptor tyrosine kinase inhibitor with potent antiangiogenesis and antitumor activity (IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ an...
T6930	Pazopanib Hydrochloride	635702-64-6	99.69%
T6930	Pazopanib Hydrochloride (Votrient HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM...
T6711	Tyrphostin AG1296	146535-11-7	99.68%
T6711	Tyrphostin AG1296 (Tyrphostin AG 1296) is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR.
TN2354	Methylnissolin	73340-41-7	99.68%
TN2354	Methylnissolin (3-Hydroxy-9,10-dimethoxyptercarpan) is derived from Astragalus and has antibacterial and anti-cancer effects.
T6289	Dovitinib	405169-16-6	99.66%
T6289	Dovitinib (CHIR-258) (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit, IC50: 1/2 nM), also effective to class IV (FGFR1/3) an...
T14137	AG 1295	71897-07-9	99.64%
T14137	AG 1295, a selective inhibitor of platelet-derived growth factor receptor (PDGFR) tyrosine-kinase, effectively halts PDGFR autophosphorylation without impacting ...
T60108	PDGFR Tyrosine Kinase Inhibitor III	205254-94-0	99.64%
T60108	PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III) (PDGF Receptor Tyrosine Kinase Inhibitor III) is a multikinase inhibitor that i...
T0093L	Sorafenib	284461-73-0	99.61%
T0093L	Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57/...
T15454	GW843682X	660868-91-7	99.56%
T15454	GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).
T5466	Tyrosine kinase-IN-1	705946-27-6	99.55%
T5466	Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively）
T5109	Avapritinib	1703793-34-3	99.5%
T5109	Avapritinib (BLU-285) is a dual inhibitor of the mutant KIT receptor (KIT D816V, IC50: 0.27 nM) and PDGFRα (PDGFRα D842V, IC50: 0.24 nM).
T1792L	Regorafenib monohydrate	1019206-88-2	99.47%
T1792L	Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR...
T12145L	N-Desethylsunitinib hydrochloride	1261432-05-6	99.42%
T12145L	N-Desethylsunitinib hydrochloride is a major and pharmacologically active metabolite of sunitinib, which is potent, ATP-competitive VEGFR, PDGFRβ, and KIT inhibi...
T3476	JI-101	900573-88-8	99.41%
T3476	JI-101 (CGI-1842) is an oral multi-kinase inhibitor that targets vascular endothelial growth factor receptor type 2 (VEGFR-2), platelet derived growth factor rec...
T73300	AXL-IN-13	2376928-82-2	99.38%
T73300	AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 value of 1.6 nM and a Kd value of 0.26 nM.AXL-IN-13 exhibits anticancer activity, reverses TGF...
T2479	Tyrphostin A9	10537-47-0	99.36%
T2479	Tyrphostin A9 (SF 6847) is an Agricultural acaricide, now superseded. Tyrphostin A9 is firstly designed as an EGFR inhibitor
T4191	Multi-kinase inhibitor 1	778274-97-8	99.34%
T4191	Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) is a Multi-kinase inhibitor.