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PDE

A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases (which all break the phosphodiester backbone of DNA or RNA), as well as numerous less-well-characterized small-molecule phosphodiesterases.The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T0160 Anagrelide 68475-42-3 100%
Anagrelide
Anagrelide (Xagrid) is a Platelet-reducing Agent. The mechanism of action of anagrelide is as a Phosphodiesterase 3 Inhibitor. The physiologic effect of anagreli...
T68138 Saterinone 102669-89-6 100%
Saterinone
Saterinone is a potent and selective phosphodiesterase III inhibitor and a potent antagonist of the vascular α-1-adrenoceptor. Saterinone has vasodilatory proper...
T1618 Dipyridamole 58-32-2 100%
Dipyridamole
Dipyridamole (Persantin) is a Platelet Aggregation Inhibitor. The physiologic effect of dipyridamole is by means of Decreased Platelet Aggregation.
T67775 Enpp/Carbonic anhydrase-IN-1 2883495-35-8 100%
Enpp/Carbonic anhydrase-IN-1
Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase. Enpp/Carbonic anhydrase-IN-1 exhibits IC50s of 1.36, 1.35, 3.00,...
T17199 Udenafil 268203-93-6 100%
Udenafil
Udenafil is an inhibitor of PDE5 .
T8454 SEP-0372814 1516895-53-6 100%
SEP-0372814
SEP-0372814 is a potent inhibitor of PDE10.
T0167 Vinpocetine 42971-09-5 100%
Vinpocetine
Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
T10316 AN3199 1187187-10-5 100%
AN3199
AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.
T11220L UK 227786 150452-21-4 100%
UK 227786
UK 227786 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.
T23638 Adibendan 100510-33-6 100%
Adibendan
Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.
T6983 Sildenafil Mesylate 1308285-21-3 100%
Sildenafil Mesylate
Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.
T12395 PDE9-IN-1 2305087-92-5 100%
PDE9-IN-1
PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).
T28367 PF-04822163 1798334-07-2 100%
PF-04822163
PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.
T0994 Ketotifen fumarate 34580-14-8
Ketotifen fumarate
Ketotifen fumarate (HC 20511 fumarate) is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators.
T12150 N-Methylbenzamide 613-93-4
N-Methylbenzamide
N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.
T23154 Piclamilast 144035-83-6 98%
Piclamilast
Piclamilast (RP 73401) is a PDE4 inhibitor.
T0383 Fenspiride hydrochloride 5053-08-7 98%
Fenspiride hydrochloride
Fenspiride hydrochloride (Decaspiride) , an oxazolidinone spiro compound, is a drug used in the therapy of certain respiratory diseases. It is approved for use i...
T14507 Bay 60-7550 439083-90-6 98%
Bay 60-7550
Bay 60-7550 is a selective and potent PDE2 inhibitor (Ki: 3.8 nM) that exerts positive inotropic effects on rat heart by increasing PKA-mediated phosphorylation ...
T0264 Zomepirac sodium salt 64092-48-4 98%
Zomepirac sodium salt
Zomepirac sodium salt (McN-2783-21-98) is a prostaglandin synthetase inhibitor.
T17284 Zardaverine 101975-10-4 98%
Zardaverine
Zardaverine (BY 290) is an orally available, selective and potent PDE3/4 inhibitor with bronchodilator activity and anti-hepatocarcinogenic activity.Zardaverine'...
Anagrelide
T0160
Anagrelide (Xagrid) is a Platelet-reducing Agent. The mechanism of action of anagrelide is as a Phosphodiesterase 3 Inhibitor. The physiologic effect of anagreli...
Saterinone
T68138
Saterinone is a potent and selective phosphodiesterase III inhibitor and a potent antagonist of the vascular α-1-adrenoceptor. Saterinone has vasodilatory proper...
Dipyridamole
T1618
Dipyridamole (Persantin) is a Platelet Aggregation Inhibitor. The physiologic effect of dipyridamole is by means of Decreased Platelet Aggregation.
Enpp/Carbonic anhydrase-IN-1
T67775
Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase. Enpp/Carbonic anhydrase-IN-1 exhibits IC50s of 1.36, 1.35, 3.00,...
Udenafil
T17199
Udenafil is an inhibitor of PDE5 .
SEP-0372814
T8454
SEP-0372814 is a potent inhibitor of PDE10.
Vinpocetine
T0167
Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
AN3199
T10316
AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.
UK 227786
T11220L
UK 227786 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.
Adibendan
T23638
Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.
Sildenafil Mesylate
T6983
Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.
PDE9-IN-1
T12395
PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).
PF-04822163
T28367
PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.
Ketotifen fumarate
T0994
Ketotifen fumarate (HC 20511 fumarate) is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators.
N-Methylbenzamide
T12150
N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.
Piclamilast
T23154
Piclamilast (RP 73401) is a PDE4 inhibitor.
Fenspiride hydrochloride
T0383
Fenspiride hydrochloride (Decaspiride) , an oxazolidinone spiro compound, is a drug used in the therapy of certain respiratory diseases. It is approved for use i...
Bay 60-7550
T14507
Bay 60-7550 is a selective and potent PDE2 inhibitor (Ki: 3.8 nM) that exerts positive inotropic effects on rat heart by increasing PKA-mediated phosphorylation ...
Zomepirac sodium salt
T0264
Zomepirac sodium salt (McN-2783-21-98) is a prostaglandin synthetase inhibitor.
Zardaverine
T17284
Zardaverine (BY 290) is an orally available, selective and potent PDE3/4 inhibitor with bronchodilator activity and anti-hepatocarcinogenic activity.Zardaverine'...
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TargetMol