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NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN1834 Kobusin 36150-23-9 98%
Kobusin
Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammat...
TN3070 4beta-Hydroxywithanolide E 54334-04-2 98%
4beta-Hydroxywithanolide E
4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progr...
T12942 SN50 213546-53-3 98%
SN50
SN50 is a cell permeable NF-κB translocation inhibitor.
TN3931 Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid 57719-81-0 98%
ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
T11018 DHMEQ racemate 287194-38-1 98%
DHMEQ racemate
DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.
TN4162 Goshonoside F5 90851-28-8 98%
Goshonoside F5
Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
TN4315 Isonardosinone 27062-01-7 98%
Isonardosinone
Isonardosinone shows potential role in the treatment of neuroinflammation conditions, it inhibits NF-κB- and MAPK-mediated inflammatory pathways.
TN1504 Citreorosein 481-73-2 98%
Citreorosein
Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both...
TN1094 Ginsenoside Rg6 147419-93-0 98%
Ginsenoside Rg6
Ginsenoside Rg6 can inhibit JK cell proliferation in human lymphocytoma and induce its apoptosis, the mechanism may through mitochondrial dysfunction and an incr...
TN1562 Dehydromiltirone 116064-77-8 98%
Dehydromiltirone
Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then inhibiting NF...
TN1960 Mussaenoside 64421-27-8 98%
Mussaenoside
Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB.
TN4399 Kushenol C 99119-73-0 98%
Kushenol C
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
TN4648 Nepetoidin B 55486-06-1 98%
Nepetoidin B
Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly via modulation of iNOS mediated ...
TN4046 Excisanin A 78536-37-5 98%
Excisanin A
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
T12975 Sootepin D 1154518-97-4 98%
Sootepin D
Sootepin D is a triterpene from the apical bud of Gardenia sootepensis, and is TNF-α-induced NF-κB inhibitor(IC50 of 8.3μM),with anti-inflammatory activity.
TN1660 Ganoderic acid C1 95311-97-0 98%
Ganoderic acid C1
Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ac...
TN1359 Aflatoxin G1 1165-39-5 98%
Aflatoxin G1
Aflatoxin G1 (AFG1 ), a member of the AF family with cytotoxic and carcinogenic properties, could cause DNA damage in alveolar type II (AT-II) cells and induce l...
TN3517 Bisacurone 120681-81-4 98%
Bisacurone
Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
TN2641 15-Methoxypinusolidic acid 769928-72-5 98%
15-Methoxypinusolidic acid
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
TN5153 Torilin 13018-10-5 98%
Torilin
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic...
Kobusin
TN1834
Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammat...
4beta-Hydroxywithanolide E
TN3070
4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progr...
SN50
T12942
SN50 is a cell permeable NF-κB translocation inhibitor.
ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid
TN3931
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
DHMEQ racemate
T11018
DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.
Goshonoside F5
TN4162
Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
Isonardosinone
TN4315
Isonardosinone shows potential role in the treatment of neuroinflammation conditions, it inhibits NF-κB- and MAPK-mediated inflammatory pathways.
Citreorosein
TN1504
Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both...
Ginsenoside Rg6
TN1094
Ginsenoside Rg6 can inhibit JK cell proliferation in human lymphocytoma and induce its apoptosis, the mechanism may through mitochondrial dysfunction and an incr...
Dehydromiltirone
TN1562
Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then inhibiting NF...
Mussaenoside
TN1960
Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB.
Kushenol C
TN4399
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
Nepetoidin B
TN4648
Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly via modulation of iNOS mediated ...
Excisanin A
TN4046
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
Sootepin D
T12975
Sootepin D is a triterpene from the apical bud of Gardenia sootepensis, and is TNF-α-induced NF-κB inhibitor(IC50 of 8.3μM),with anti-inflammatory activity.
Ganoderic acid C1
TN1660
Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ac...
Aflatoxin G1
TN1359
Aflatoxin G1 (AFG1 ), a member of the AF family with cytotoxic and carcinogenic properties, could cause DNA damage in alveolar type II (AT-II) cells and induce l...
Bisacurone
TN3517
Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
15-Methoxypinusolidic acid
TN2641
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
Torilin
TN5153
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic...
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TargetMol