NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product name	CAS No.	Purity
T4S1962	Beta-Asarone	5273-86-9	99.32%
T4S1962	1. beta-Asarone (Cis-Isoelemicin) may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing RO...
T25450	GGTI 2147	191102-87-1	99.32%
T25450	GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.
T3416	Aucubin	479-98-1	99.31%
T3416	Aucubin (Rhinanthin) is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.
T9105	NF-κB-IN-1	1227098-15-8	99.29%
T9105	NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathway inhib...
T5S0754	Isoquercetin	482-35-9	99.29%
T5S0754	1. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as ...
T16324	Nimbolide	25990-37-8	99.28%
T16324	Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis th...
TN1525	Convallatoxin	508-75-8	99.27%
TN1525	Convallatoxin is a natural product
T6718	Zingerone	122-48-5	99.26%
T6718	Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antidiarrhoeic, antilipol...
T27034	CL075	256922-53-9	99.25%
T27034	CL075 (3M002) is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 to e...
T16706	Quinoclamine	2797-51-5	99.25%
T16706	Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor.
TL0016	Sulforaphene	592-95-0	99.19%
TL0016	Sulforaphene is a natural product isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes canc...
T2898	Andrographolide	5508-58-7	99.18%
T2898	Andrographolide (Andrographis)(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potential a...
T5S2129	Sciadopitysin	521-34-6	99.17%
T5S2129	Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin sh...
TN1051	1-Caffeoylquinic acid	1241-87-8	99.16%
TN1051	1-Caffeoylquinic acid is an important intermediate in lignin biosynthesis. 1-Caffeoylquinic acid has anti-influenza, and antioxidant activities, it also slows th...
T2761	Naringin dihydrochalcone	18916-17-1	99.16%
T2761	Naringin dihydrochalcone (Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.
T3772	Maslinic acid	4373-41-5	99.16%
T3772	Maslinic acid (Crategolic acid) is a DNA polymerase B inhibitor.
T3826	Polygalasaponin F	882664-74-6	99.15%
T3826	Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and re...
T4564	Ethacrynic acid	58-54-8	99.15%
T4564	Ethacrynic acid (Edecrin) is a nonsulfonamide loop diuretic that inhibits the activity of the Na+/K+/2Cl- cotransporter NKCC2 in the thick ascending limb of the ...
T2878	Ginsenoside Rd	52705-93-8	99.13%
T2878	Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.
TQ0185	14-Deoxy-11,12-didehydroandrographolide	42895-58-9	99.13%
TQ0185	14-Deoxy-11,12-didehydroandrographolide (AP10) has hypotensive, anti-inflammatory, anti-asthma, and anti-cancer actions. It can inhibit NF-κB activation.