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JNK

JNK signaling pathway is such a death pathway that control cell death. There are two main downstream signaling of JNK pathway: one is activation of death signaling such c-Jun, Fos and apoptosis signaling such as BIM, BAD, BAX protein or active P53 transcription, to promote cell apoptosis; the other is inhibition of the cell survival signaling such as STATs and CREB .
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T3200 DB07268 929007-72-7
DB07268
DB07268 is a potent and selective JNK1 inhibitor.
T8661 AS601245.2TFA (345987-15-7 free base) 345987-16-8 98%
AS601245.2TFA (345987-15-7 free base)
AS601245.2TFA (345987-15-7 free base) (AS601245.2TFA) is a cell-permeable Inhibitor of JNK (IC50s of 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectivel...
TN1403 Arjunolic acid 465-00-9 98%
Arjunolic acid
Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the devel...
TN1493 Chrysosplenol D 14965-20-9 98%
Chrysosplenol D
Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.
TN1236 3',4',7-Trihydroxyisoflavone 485-63-2 98%
3',4',7-Trihydroxyisoflavone
3',4',7-Trihydroxyisoflavone is a soy isoflavone soy glycoside derivative and Cot (Tpl2/MAP3K8) and MKK4 inhibitor with anticancer, antiangiogenic and free radic...
T2S1040 Jolkinolide B 37905-08-1 98%
Jolkinolide B
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
TN1013 Cucurbitacin D 3877-86-9 98%
Cucurbitacin D
Cucurbitacin D has anticancer effects, it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells.
DB07268
T3200
DB07268 is a potent and selective JNK1 inhibitor.
AS601245.2TFA (345987-15-7 free base)
T8661
AS601245.2TFA (345987-15-7 free base) (AS601245.2TFA) is a cell-permeable Inhibitor of JNK (IC50s of 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectivel...
Arjunolic acid
TN1403
Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the devel...
Chrysosplenol D
TN1493
Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.
3',4',7-Trihydroxyisoflavone
TN1236
3',4',7-Trihydroxyisoflavone is a soy isoflavone soy glycoside derivative and Cot (Tpl2/MAP3K8) and MKK4 inhibitor with anticancer, antiangiogenic and free radic...
Jolkinolide B
T2S1040
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
Cucurbitacin D
TN1013
Cucurbitacin D has anticancer effects, it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells.
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TargetMol