JNK

JNK signaling pathway is such a death pathway that control cell death. There are two main downstream signaling of JNK pathway: one is activation of death signaling such c-Jun, Fos and apoptosis signaling such as BIM, BAD, BAX protein or active P53 transcription, to promote cell apoptosis; the other is inhibition of the cell survival signaling such as STATs and CREB .

Cat. No.	Product name	CAS No.	Purity
TN1879	Lucideric acid A	95311-94-7	98.05%
TN1879	Lucideric acid A (Lucidenic acid A) is a modulator of JNK and p38 and enhances LPS-induced immune responses in monocytic THP-1 cells possibly via the modulation ...
T4592	TOMATIDINE HYDROCHLORIDE	6192-62-7	98%
T4592	Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a neg...
T5574	Guggulsterone	95975-55-6	98%
T5574	Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.
T5833	CC-401 Hydrochloride	1438391-30-0	98%
T5833	CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor (Ki of 25 to 50 nM.)with potenti...
T3627	IQ-1S free acid	23146-22-7	97.82%
T3627	IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inf...
T5094	IRAK inhibitor 1	1042224-63-4	97.78%
T5094	IRAK inhibitor 1 is an effective IRAK-4 inhibitor (IC50: 216 nM), is poorly active against JNK-1 (IC50: 3.801 μM) and JNK-2 (IC50>10 μM).
TN1702	Glycycoumarin	94805-82-0	97.64%
TN1702	Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.
T73182	BSJ-04-122	2513289-74-0	97.58%
T73182	BSJ-04-122 is a covalent MKK4/7 dual inhibitor that inhibits MKK4 and MKK7 with IC50 values of 4 nM and 181 nM, respectively.BSJ-04-122 can be used for cancer re...
T13018	SU3327	40045-50-9	97.13%
T13018	SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).
T2675	Bentamapimod	848344-36-5	95.21%
T2675	Bentamapimod (AS 602801) is a novel, orally active inhibitor of JNK.
T4S2326	Cornuside	131189-57-6	100%
T4S2326	1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in t...
T6784	BI-78D3	883065-90-5	100%
T6784	BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.
TP1897L1	JIP-1 (153-163) acetate(438567-88-5 free base)	TP1897L1	100%
TP1897L1	JIP-1 (153-163) acetate is a peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1).
T3S0209	Vincristine	57-22-7	100%
T3S0209	Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-...
T7190	Actein	18642-44-9
T7190	Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblast...
T2234	TCS JNK 5a	312917-14-9
T2234	TCS JNK 5a (SC202671) is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5).
T9688	CC-90001	1403859-14-2
T9688	CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.
TN1448	(-)-Bornyl acetate	5655-61-8
TN1448	(-)-Bornyl acetate (L-(-)-Bornyl acetate) is a less active enantiomer of (+)-Bornyl acetate. (-)-Bornyl acetate isolates from hyssop oil and possesses antifungal...
TN3967	Epieriocalyxin A	191545-24-1
TN3967	Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.
T8477	IQ-3	312538-03-7
T8477	IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in ...