Integrin

Integrins are proteins that function mechanically, by attaching the cell cytoskeleton to the extracellular matrix (ECM), and biochemically, by sensing whether adhesion has occurred. The integrin family of proteins consists of alpha and beta subtypes, which form transmembrane heterodimers.

Cat. No.	Product name	CAS No.	Purity
T3862	Irigenin	548-76-5	99.71%
T3862	Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the Extra Domain...
T39615L	P8RI acetate		99.61%
T39615L	P8RI acetate is a biomimetic peptide of CD31 and an agonist of CDP8RI acetate shows an immunosuppressive effect through the restoration of the CD31 inhibitory pa...
T24733	Roxifiban acetate	176022-59-6	99.56%
T24733	Roxifiban acetate（DMP 754 acetate） is a potent GP IIb / IIIa antagonist that exhibits antiplatelet aggregation activity via immune mediation and can be used in t...
T39933	Bexotegrast	2376257-44-0	99.53%
T39933	Bexotegrast (PLN-74809) is an orally active and potent inhibitor of αvβ6 and αvβ1 integrins with antifibrotic effects, inhibits αvβ6 and αvβ1-induced activation ...
T3977	Lifitegrast	1025967-78-5	99.40%
T3977	Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.
T5488	ILK-IN-2	1333146-24-9	99.31%
T5488	ILK-IN-2 (OSU-T315) is a novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 μM.
T60101	PLN-1474	2408065-32-5	99.25%
T60101	PLN-1474 is a potent αVβ1 inhibitor with IC50 < 50 nM.
T12783	RWJ 50271	162112-37-0	99.22%
T12783	RWJ 50271 is a selective lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction inhibitor( IC50 of 5.0 μM in HL60 c...
T68078	Gantofiban	183547-57-1	99.21%
T68078	Gantofiban is a glycoprotein IIb/IIIa (GP IIb/IIIa) antagonist used in the treatment of cardiovascular disease and may be used to study thrombosis.
TQ0291	Firategrast	402567-16-2	99.16%
TQ0291	Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervous ...
T4259	GLPG0187	1320346-97-1	99.12%
T4259	GLPG0187, a broad spectrum integrin receptor antagonist, inhibits αvβ1-integrin (IC50: 1.3 nM).
T6966	RGD	99896-85-2	99.11%
T6966	RGD (RGD (Arg-Gly-Asp) Peptides) (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.
T4435	E7820	289483-69-8	99.11%
T4435	E7820 (ER68203-00) is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells).
T3404	Cucurbitacin B	6199-67-3	99.08%
T3404	Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation throug...
T26917	BTT-3033	1259028-99-3	98.91%
T26917	BTT-3033 is an orally active and potent α2β1 (EC50: 130 nM) inhibitor with an EC50 value of 130 nM. BTT-3033 has an affinity for the α2I domain and inhibits plat...
TP2384L	Hexapeptide-10 Acetate	TP2384L	98.84%
TP2384L	Hexapeptide-10 Acetate (Hexapeptide-10 Acetate) is a synthetic peptide. It increases the synthesis of laminin V and α6-integrin to promote cell binding, with ext...
TP1204	IRGD peptide	1392278-76-0	98.77%
TP1204	iRGD peptide (c(CRGDKGPDC)) is a 9-amino acid cyclic peptide (sequence: CRGDKGPDC) and a molecular mimicry agent that was originally identified in an in vivo scr...
T30751	Carotegrast methyl	401905-67-7	98.73%
T30751	Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist.
TQ0250	CWHM-12	1564286-55-0	98.5%
TQ0250	CWHM-12 is a potent inhibitor of αV integrins (IC50s of 0.2/0.8/1.5/1.8 nM for αvβ8/αvβ3/αvβ6/αvβ1).
T3638	Leukadherin-1	344897-95-6	98.49%
T3638	Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendot...