T7692 |
2,4-DPD
|
41438-38-4
|
98.98%
|
|
2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)
|
T10233 |
Acetylarenobufagin
|
184673-79-8
|
98.54%
|
|
Acetylarenobufagin is a steroidal hypoxia-inducible factor-1 (HIF-1) modulator.
|
T4S0800 |
Demethyleneberberine
|
25459-91-0
|
98.54%
|
|
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either ...
|
T61349 |
HIF-1α-IN-2
|
2762315-06-8
|
98.45%
|
|
HIF-1α-IN-2 is a novel and highly potent HIF-1α inhibitor with anticancer and antitumor activity that inhibits the expression of HIF-1α and VEGF in a dose-depend...
|
T67831 |
HIF-2α agonist 2
|
2750141-15-0
|
98.32%
|
|
HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structu...
|
T15396 |
GN44028
|
1421448-26-1
|
98.20%
|
|
GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 ...
|
T5537 |
IDF-11774
|
1429054-28-3
|
98%
|
|
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
|
T36711 |
FM19G11
|
329932-55-0
|
97.28%
|
|
FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).
|
T29797 |
AKB-6899
|
1007377-55-0
|
97.11%
|
|
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macr...
|
T6961 |
PX-478
|
685898-44-6
|
97%
|
|
PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-...
|
T3027 |
Sodium Aescinate
|
20977-05-3
|
95.17%
|
|
Sodium Aescinate (Escin sodium salt) is extracted from Aesculus wilsonii.
|
T11589 |
Hydroxycitric acid tripotassium hydrate
|
6100-05-6
|
95%
|
|
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-...
|
T4S1551 |
Cinnamaldehyde
|
104-55-2
|
85%
|
|
1. Cinnamaldehyde (Cinnamic Aldehyde) has antipyretic activity. 2. Cinnamaldehyde is a sedative agent. 3. Cinnamaldehyde inhibits invasive capabilities of MDA-MB...
|
T7802 |
M1001
|
874590-32-6
|
100%
|
|
M1001 is a HIF-2α agonist.
|
T17009 |
TC-S 7009
|
1422955-31-4
|
100%
|
|
TC-S 7009 is a potent and selective HIF-2α inhibitor (Kd: 81 nM). The affinity of TC-S 7009 to HIF-2α was higher than that of HIF-1α (Kd >> 5μM). TC-S 7009 disru...
|
T13925 |
THS-044
|
62054-67-5
|
100%
|
|
THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activity in...
|
TQ0121 |
VH-298
|
2097381-85-4
|
100%
|
|
VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein...
|
T1939 |
DMOG
|
89464-63-1
|
|
|
DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.
|
T21494 |
Oligomycin
|
1404-19-9
|
98%
|
|
Oligomycin is an antifungal antibiotic that is an inhibitor of H+-ATP synthetase. The Oligomycin blocks oxidative phosphorylation and the electron transport chai...
|
T15482 |
HIF-2α-IN-1
|
1799948-06-3
|
98%
|
|
HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.
|