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HIF

Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene. It is a basic helix-loop-helix PAS domain containing protein, and is considered as the master transcriptional regulator of cellular and developmental response to hypoxia. The dysregulation and overexpression of HIF1A by either hypoxia or genetic alternations have been heavily implicated in cancer biology, as well as a number of other pathophysiologies, specifically in areas of vascularization and angiogenesis, energy metabolism, cell survival, and tumor invasion. Two other alternative transcripts encoding different isoforms have been identified.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T7692 2,4-DPD 41438-38-4 98.98%
2,4-DPD
2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)
T10233 Acetylarenobufagin 184673-79-8 98.54%
Acetylarenobufagin
Acetylarenobufagin is a steroidal hypoxia-inducible factor-1 (HIF-1) modulator.
T4S0800 Demethyleneberberine 25459-91-0 98.54%
Demethyleneberberine
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either ...
T61349 HIF-1α-IN-2 2762315-06-8 98.45%
HIF-1α-IN-2
HIF-1α-IN-2 is a novel and highly potent HIF-1α inhibitor with anticancer and antitumor activity that inhibits the expression of HIF-1α and VEGF in a dose-depend...
T67831 HIF-2α agonist 2 2750141-15-0 98.32%
HIF-2α agonist 2
HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structu...
T15396 GN44028 1421448-26-1 98.20%
GN44028
GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 ...
T5537 IDF-11774 1429054-28-3 98%
IDF-11774
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
T36711 FM19G11 329932-55-0 97.28%
FM19G11
FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).
T29797 AKB-6899 1007377-55-0 97.11%
AKB-6899
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macr...
T6961 PX-478 685898-44-6 97%
PX-478
PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-...
T3027 Sodium Aescinate 20977-05-3 95.17%
Sodium Aescinate
Sodium Aescinate (Escin sodium salt) is extracted from Aesculus wilsonii.
T11589 Hydroxycitric acid tripotassium hydrate 6100-05-6 95%
Hydroxycitric acid tripotassium hydrate
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-...
T4S1551 Cinnamaldehyde 104-55-2 85%
Cinnamaldehyde
1. Cinnamaldehyde (Cinnamic Aldehyde) has antipyretic activity. 2. Cinnamaldehyde is a sedative agent. 3. Cinnamaldehyde inhibits invasive capabilities of MDA-MB...
T7802 M1001 874590-32-6 100%
M1001
M1001 is a HIF-2α agonist.
T17009 TC-S 7009 1422955-31-4 100%
TC-S 7009
TC-S 7009 is a potent and selective HIF-2α inhibitor (Kd: 81 nM). The affinity of TC-S 7009 to HIF-2α was higher than that of HIF-1α (Kd >> 5μM). TC-S 7009 disru...
T13925 THS-044 62054-67-5 100%
THS-044
THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activity in...
TQ0121 VH-298 2097381-85-4 100%
VH-298
VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein...
T1939 DMOG 89464-63-1
DMOG
DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.
T21494 Oligomycin 1404-19-9 98%
Oligomycin
Oligomycin is an antifungal antibiotic that is an inhibitor of H+-ATP synthetase. The Oligomycin blocks oxidative phosphorylation and the electron transport chai...
T15482 HIF-2α-IN-1 1799948-06-3 98%
HIF-2α-IN-1
HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.
2,4-DPD
T7692
2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)
Acetylarenobufagin
T10233
Acetylarenobufagin is a steroidal hypoxia-inducible factor-1 (HIF-1) modulator.
Demethyleneberberine
T4S0800
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either ...
HIF-1α-IN-2
T61349
HIF-1α-IN-2 is a novel and highly potent HIF-1α inhibitor with anticancer and antitumor activity that inhibits the expression of HIF-1α and VEGF in a dose-depend...
HIF-2α agonist 2
T67831
HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structu...
GN44028
T15396
GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 ...
IDF-11774
T5537
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
FM19G11
T36711
FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).
AKB-6899
T29797
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macr...
PX-478
T6961
PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-...
Sodium Aescinate
T3027
Sodium Aescinate (Escin sodium salt) is extracted from Aesculus wilsonii.
Hydroxycitric acid tripotassium hydrate
T11589
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-...
Cinnamaldehyde
T4S1551
1. Cinnamaldehyde (Cinnamic Aldehyde) has antipyretic activity. 2. Cinnamaldehyde is a sedative agent. 3. Cinnamaldehyde inhibits invasive capabilities of MDA-MB...
M1001
T7802
M1001 is a HIF-2α agonist.
TC-S 7009
T17009
TC-S 7009 is a potent and selective HIF-2α inhibitor (Kd: 81 nM). The affinity of TC-S 7009 to HIF-2α was higher than that of HIF-1α (Kd >> 5μM). TC-S 7009 disru...
THS-044
T13925
THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activity in...
VH-298
TQ0121
VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein...
DMOG
T1939
DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.
Oligomycin
T21494
Oligomycin is an antifungal antibiotic that is an inhibitor of H+-ATP synthetase. The Oligomycin blocks oxidative phosphorylation and the electron transport chai...
HIF-2α-IN-1
T15482
HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.
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TargetMol