HIF

Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene. It is a basic helix-loop-helix PAS domain containing protein, and is considered as the master transcriptional regulator of cellular and developmental response to hypoxia. The dysregulation and overexpression of HIF1A by either hypoxia or genetic alternations have been heavily implicated in cancer biology, as well as a number of other pathophysiologies, specifically in areas of vascularization and angiogenesis, energy metabolism, cell survival, and tumor invasion. Two other alternative transcripts encoding different isoforms have been identified.

Cat. No.	Product name	CAS No.	Purity
T19832	Acriflavine Hydrochloride	8063-24-9	99.69%
T19832	Acriflavine Hydrochloride (Acriflavine HCl) is a HIF-1α inhibitor. It acts by targeting HIF-1α-mediated pathways and decreasing the level of PGK1, VEGF, and HIF-...
T124358	Deferoxamine	70-51-9	99.66%
T124358	Deferoxamine（Desferrioxamine B） is an iron chelator (binds Fe(III) and many other metal cations) that inhibits neuronopathy, may be used to modify the reduction ...
T2488	BAY 87-2243	1227158-85-1	99.65%
T2488	BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
T0153	Oltipraz	64224-21-1	99.56%
T0153	Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes...
T60413	HIF-IN-1	2393928-76-0	99.48%
T60413	HIF-IN-1 is a potent inhibitor of hypoxia-inducible factor (HIF-1), which is associated with tumor and cancer cell proliferation and inhibits HIF-1α protein aggr...
T9890	HIF1-IN-3	333314-79-7	99.48%
T9890	HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used in antica...
T4381	Lificiguat	170632-47-0	99.48%
T4381	Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha)...
T7848	PT-2385	1672665-49-4	99.39%
T7848	PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).
T36953	Naphthofluorescein	61419-02-1	99.34%
T36953	Naphthofluorescein （Naphthafluorescein） is a Mint3 inhibitor with potential antitumor and anti-inflammatory activities, inhibits the interaction between HIF-1 an...
T15205	EL-102	1233948-61-2	99.34%
T15205	EL-102 is a HIF1α inhibitor with anticancer activity that inhibits microtubule protein polymerization and can be used to study prostate cancer.
T16679	Belzutifan	1672668-24-4	99.34%
T16679	Belzutifan (MK-6482) is a potential treatment for clear cell renal cell carcinoma (ccRCC). Belzutifan is an orally active and selective HIF-2α inhibitor (IC50: 9...
T11561	HIF-2α-IN-2	1672666-82-8	99.33%
T11561	HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).
T67767	HIF-1 inhibitor-4	333357-56-5	99.17%
T67767	HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM. HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA lev...
T3169	KC7F2	927822-86-4	99.11%
T3169	KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.
T3494	LW6	934593-90-5	99.10%
T3494	LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.
T13050	SYP-5	1384268-04-5	99.1%
T13050	SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.
T6929	Pantoprazole sodium	138786-67-1	99.1%
T6929	Pantoprazole sodium (Pantecta) is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole sodium is a lipophilic, w...
T3404	Cucurbitacin B	6199-67-3	99.08%
T3404	Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation throug...
T12675L	PT2399	1672662-14-4	99.07%
T12675L	PT2399 shows effective antitumor activity in vivo. PT2399 is an effective and selective HIF-2α antagonist, which directly binds to the HIF-2α PAS B domain (IC50:...
T7836	ML228	1357171-62-0	99.03%
T7836	ML228 is a potent the Hypoxia Inducible Factor (HIF) pathway activator with EC50 of 1 μM. ML228 potently activates HIF in vitro as well as its downstream target ...