Glucocorticoid Receptor

The glucocorticoid receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response.

Cat. No.	Product name	CAS No.	Purity
T3962	TPI-1	79756-69-7	99.79%
T3962	TPI-1 is a SHP-1 inhibitor.
T1076	Dexamethasone	50-02-2	99.77%
T1076	Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activit...
T6503	Fluorometholone Acetate	3801-06-7	99.77%
T6503	Fluorometholone Acetate (Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
T1102	Mifepristone	84371-65-3	99.74%
T1102	Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
T1559	Betamethasone dipropionate	5593-20-4	99.74%
T1559	Betamethasone Dipropionate is the 17, 21-dipropionate ester of betamethasone, a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory ...
T1284	Megestrol acetate	595-33-5	99.72%
T1284	Megestrol acetate (BDH1298) is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic pr...
T0343	Nimodipine	66085-59-4	99.71%
T0343	Nimodipine (BAY-e 9736), a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.
T0276	Hydrocortisone Valerate	57524-89-7	99.69%
T0276	Hydrocortisone Valerate (Westcort) has anti-inflammatory, antipruritic and vasoconstrictive properties.
T67742	EX-A5386	2452396-89-1	99.69%
T67742	EX-A5386 (Glucocorticoid receptor modulator-1) is a potent glucocorticoid receptor modulator, IC50/EC50<100nM.
T8777	Beclometasone	4419-39-0	99.68%
T8777	Beclometasone is a prototype glucocorticoid receptor agonist. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of asthma....
T15246	Esaxerenone	1632006-28-0	99.68%
T15246	Esaxerenone (XL-550) is a highly potent and selective non-steroidal antagonist of the mineralocorticoid receptor.
T34383	Rofleponide	144459-70-1	99.67%
T34383	Rofleponide is a synthetic glucocorticosteroid with a high affinity for the rat thymus glucocorticoid receptor.
T0188	Fluticasone (propionate)	80474-14-2	99.65%
T0188	Fluticasone propionate (CCI-187881), derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid recep...
T14301	Apararenone	945966-46-1	99.65%
T14301	Apararenone (MT-3995) is a receptor antagonist of mineralocorticoid receptor which can be used to treat non-alcoholic steatohepatitis and diabetic nephropathy.
T0476	Spironolactone	52-01-7	99.63%
T0476	Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.
T15451	GW-870086	827319-43-7	99.63%
T15451	GW-870086 is an effective anti-inflammatory agent. GW-870086 also plays a role in a glucocorticoid receptor agonist (pIC50: 10.1 in A549 cells expressing NF-κB)....
T22367	Methylprednisolone succinate	2921-57-5	99.60%
T22367	Methylprednisolone succinate (Methylprednisolone hemisuccinate) is a synthetic glucocorticoid and is widely used as an anti-inflammatory agent.
T21404	Fluticasone furoate	397864-44-7	99.58%
T21404	Fluticasone furoate (Avamys) is a synthetic trifluorinated corticosteroid derived from fluticasone with a Kd of 0.3 nM. Fluticasone furoate has potent anti-infla...
T1243	Hydrocortisone acetate	50-03-3	99.58%
T1243	Hydrocortisone acetate (Cortisol 21-acetate) is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive ...
T1531	Mometasone furoate	83919-23-7	99.56%
T1531	Mometasone furoate (Sch32088) is a pregnadienediol derivative ANTI-ALLERGIC AGENT and ANTI-INFLAMMATORY AGENT that is used in the management of ASTHMA and ALLERG...