T11279 |
FGFR1/DDR2 inhibitor 1
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2308497-58-5
|
99.14%
|
|
FGFR1/DDR2 inhibitor 1 is an inhibitor of discoindin domain receptor 2 (DDR2) and fibroblast growth factor receptor 1 (FGFR1), with IC50 values of 31.1 nM, 108....
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T5044 |
Futibatinib
|
1448169-71-8
|
99.14%
|
|
Futibatinib (FGFR-IN-1) is a novel, potent and highly selective FGFR inhibitor, used for antitumor treatment.
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T6932 |
PD168393
|
194423-15-9
|
99.13%
|
|
PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.
|
T6996 |
SU 5402
|
215543-92-3
|
99.08%
|
|
SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.
|
T3726 |
Erdafitinib
|
1346242-81-6
|
99.07%
|
|
Erdafitinib (JNJ-42756493) is a quinoxaline derivative compound, acts on FGFR1/2/3/4.
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T6338 |
PHA-680632
|
398493-79-3
|
99.03%
|
|
PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGF...
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T8541 |
Lenvatinib mesylate
|
857890-39-2
|
99.03%
|
|
Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities.
|
TQ0256 |
FGFR4-IN-1
|
1708971-72-5
|
98.96%
|
|
FGFR4-IN-1 is a potent FGFR4 inhibitor (IC50: 0.7 nM).
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T6024 |
Zoligratinib
|
1265229-25-1
|
98.94%
|
|
Zoligratinib (CH5183284) is a selective and orally available FGFR inhibitor, which is for FGFR1(IC50=9.3 nM), FGFR2(IC50=7.6 nM), FGFR3(IC50=290), and FGFR4(IC50...
|
T4075 |
Sulfatinib
|
1308672-74-3
|
98.93%
|
|
Sulfatinib (KDR-IN-1) (HMPL-012) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC 50 s ranging from 1 to 24...
|
T1886 |
TAK-632
|
1228591-30-7
|
98.92%
|
|
TAK-632 is a potent pan-Raf inhibitor.
|
T2361 |
LY2874455
|
1254473-64-7
|
98.88%
|
|
LY2874455 has been used in trials studying the treatment of Advanced Cancer.
|
T5122 |
Alofanib
|
1612888-66-0
|
98.82%
|
|
Alofanib (RPT835) is a selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect on FGF2-induced phosphorylation of FRS2a in KATO III cells (I...
|
T7611 |
ODM-203
|
1430723-35-5
|
98.77%
|
|
ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity
|
T10870L |
CP-547632
|
252003-65-9
|
98.51%
|
|
CP-547632 is an orally available and potent, ATP-competitive dual inhibitor of VEGFR-2 and FGF kinase F with IC50s of 11 nM and 9 nM, respectively. CP-547632 is ...
|
T2094 |
Danusertib
|
827318-97-8
|
98.44%
|
|
Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinase...
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T3714 |
SUN11602
|
704869-38-5
|
98.43%
|
|
SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor. It mimics the neuroprotective effects of bFGF and prevent...
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T6028 |
PF 477736
|
952021-60-2
|
98.34%
|
|
PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CS...
|
T2642 |
PD173074
|
219580-11-7
|
98.15%
|
|
PD173074 is an effective FGFR1 inhibitor (IC50: 25 nM) and also inhibits VEGFR2 (IC50: 100-200 nM) in cell-free assays. The selectivity is higher ~1000-fold for ...
|
T1975 |
Infigratinib
|
872511-34-7
|
98.03%
|
|
Infigratinib (NVP-BGJ398) (BGJ398) is an orally bioavailable pan FGFR inhibitor (IC50: 0.9/1.4/1 nM for FGFR1/2/3), >40-fold selective for FGFR versus FGFR4 and ...
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