FGFR

The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of proteins. Some of these receptors are involved in pathological conditions. For example, a point mutation in FGFR3 can lead to achondroplasia.

Cat. No.	Product name	CAS No.	Purity
TQ0015	PRN1371	1802929-43-6	99.72%
TQ0015	PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).
T6930	Pazopanib Hydrochloride	635702-64-6	99.69%
T6930	Pazopanib Hydrochloride (Votrient HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM...
T6711	Tyrphostin AG1296	146535-11-7	99.68%
T6711	Tyrphostin AG1296 (Tyrphostin AG 1296) is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR.
T5170	KHS101 hydrochloride	1784282-12-7	99.6%
T5170	KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype.
T22306	DGY-06-116	T22306	99.6%
T22306	DGY-06-116 is an selective and irreversible covalent inhibitor of Src and FGFR1 with IC50 value of 3nM and 8340 nM, respectively.
T1948	AZD4547	1035270-39-3	99.56%
T1948	AZD4547, a new-type specific FGFR inhibitor, targets for FGFR1/2/3 (IC50: 0.2/2.5/1.8 nM in cell-free assays).
T5466	Tyrosine kinase-IN-1	705946-27-6	99.55%
T5466	Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively）
T1639	Amlexanox	68302-57-8	99.55%
T1639	Amlexanox (AA673) is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, f...
T6920	ON123300	1357470-29-1	99.53%
T6920	ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).
T1991	ZM323881 hydrochloride	193000-39-4	99.5%
T1991	ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor.
T12401	Pemigatinib	1513857-77-6	99.4%
T12401	Pemigatinib (INCB054828) is an orally active, selective inhibitor of FGFR(IC50s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively).
T0724	Formononetin	485-72-3	99.38%
T0724	Formononetin (Flavosil) is an O-methylated isoflavone and a phytoestrogen from the root of Astragalus membranaceus.
T6128	PHA-665752	477575-56-7	99.35%
T6128	PHA-665752 is an effective, specific and ATP-competitive c-Met inhibitor (IC50: 9 nM), >50-fold selectivity for c-Met than STKs or RTKs.
T6836	FIIN-2	1633044-56-0	99.34%
T6836	FIIN-2, an irreversible, pan-FGFR inhibitor, inhibits FGFR1/2/3/4 with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM, respectively.
T60185	FGFR2-IN-3	2549174-42-5	99.24%
T60185	FGFR2-IN-3 is an orally active selective FGFR2 inhibitor[1].
T16364	Infigratinib phosphate	1310746-10-1	99.24%
T16364	Infigratinib phosphate (BGJ-398 phosphate) is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4...
T2576	Brivanib (alaninate)	649735-63-7	99.23%
T2576	Brivanib Alaninate (BMS-582664) is the alaninate salt of a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic activit...
T23127	PD-161570	192705-80-9	99.23%
T23127	PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c...
T2215	Ferulic Acid	1135-24-6	99.21%
T2215	Ferulic Acid (Coniferic acid) is a highly abundant phenolic phytochemical and a type of organic compound found in the Ferula assafoetida L. or Ligusticum chuanxi...
T13824	PP58	212391-58-7	99.21%
T13824	PP58 is an inhibitor of PDGFR, FGFR and Src family.