Epigenetic Reader Domain

Epigenetic reader domains can be thought of as effector proteins that recognize and are recruited to specific epigenetic marks.

Cat. No.	Product name	CAS No.	Purity
T31221L	DBRD9 HCl	2341840-98-8	99.37%
T31221L	dBRD9 HCl is a PROTAC composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide . dBRD9 HCl is a potent and selective degra...
T70375	ZEN-2759	1616400-50-0	99.36%
T70375	ZEN-2759 is a potent BET small molecule inhibitor of BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2).
TL0007	Bisdemethoxycurcumin	24939-16-0	99.34%
TL0007	Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-d...
T27423	GNE-375	1926989-06-1	99.32%
T27423	GNE-375 is a selective and potent BRD9 inhibitor (IC50: 5 nM).GNE-375 inhibits BRD4, TAF1, and CECR2, and can be used to study epigenetic resistance.
T5436	MZ 1	1797406-69-9	99.31%
T5436	MZ 1 is a BRD4 protein degrader based on PROTAC technology.
T8778	TTK21	709676-56-2	99.3%
T8778	TTK21 is an activator of CBP/p300 histone acetyltransferase activity.
TQ0058	MI-463	1628317-18-9	99.28%
TQ0058	MI-463 is a potent and orally bioavailable inhibitor of the menin-mLL interaction (IC50: 15.3 nM).
T4345	CeMMEC1	440662-09-9	99.26%
T4345	CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).
T78555	BRD4 Inhibitor-27	930039-92-2	99.22%
T78555	BRD4 Inhibitor-27 is a potent BRD4 inhibitor that inhibits BRD4 BD1 and BRD4 BD2 with IC50s of 9.6 and 11.3 μM, respectively.BRD4 Inhibitor-27 has anticancer act...
T2452	C646	328968-36-1	99.21%
T2452	C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
T5468	YF-2	1311423-89-8	99.19%
T5468	YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM...
T16321	NI-42	1884640-99-6	99.17%
T16321	NI-42 is a structurally orthogonal chemical probe for the BRPFs and is biased. It effective inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; ...
T69742	SRX3177	2241237-51-2	99.16%
T69742	SRX3177 is a novel and potent inhibitor of BRD4, PI3K and CDK.SRX3177 has potential anticancer activity.
T25215	CCT077791	748777-47-1	99.15%
T25215	CCT077791 is a potent inhibitor of p300 and PCAF histone acetyltransferase activity for cancer research.
T6809	CPI-169 racemate	1450655-76-1	99.14%
T6809	CPI-169 racemate (CPI 169) is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.
T6584	MG 149	1243583-85-8	99.1%
T6584	MG 149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).
T3969	I-CBP112	1640282-31-0	99.1%
T3969	I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
T13392	ZEN-3219	1952264-34-4	99.06%
T13392	ZEN-3219 is a BET inhibitor, which has inhibitory effect on BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2). ZEN-3219 has inhibitory effect on BRD4(BD1), The IC50 values o...
T9020	GSK620	2088410-46-0	99.05%
T9020	GSK620 is a pan-BD2 inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral...
T36395	Trotabresib	1706738-98-8	99.03%
T36395	Trotabresib (CC-90010) is an orally active inhibitor of BET and can be used in studies about advanced solid tumors.