T9568 |
SGC-SMARCA-BRDVIII
|
1997319-84-2
|
99.85%
|
|
SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respect...
|
T7856 |
Naphthol AS-E
|
92-78-4
|
99.85%
|
|
Naphthol AS-E (nAS-E) is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.
|
T6908 |
NSC 228155
|
113104-25-9
|
99.84%
|
|
NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.
|
T8774 |
MS7972
|
352553-42-5
|
99.84%
|
|
MS7972 is CREBBP inhibitor that blocks human p53 and CREB binding protein association. MS7972 can almost completely block this BRD interaction at 50 μM
|
T9194 |
UMB298
|
2266569-73-5
|
99.83%
|
|
UMB298 is a potent and selective CBP/P300 bromodomain inhibitor. UMB298 inhibits BRD4 with IC50 of 5193nM.
|
T60079 |
GNE-064
|
1997321-20-6
|
99.81%
|
|
GNE-064 is a selective, orally active and highly soluble inhibitor of SMARCA4, SMARCA2 and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC50 of 0.035 μ...
|
T15441 |
GSK8573
|
1693766-04-9
|
99.81%
|
|
GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).
|
T9541 |
CTB
|
451491-47-7
|
99.80%
|
|
CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells.
|
T17311 |
(+)-JQ1 PA
|
2115701-93-2
|
99.8%
|
|
(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1(IC50 of 10.4 nM).
|
T5318 |
666-15
|
1433286-70-4
|
99.77%
|
|
666-15 (CREB inhibitor) is a potent and selective CREB inhibitor (IC50: 81 nM).
|
T8609 |
6-Bromo-3-methyl-1,4-dihydroquinazolin-2-one
|
328956-24-7
|
99.76%
|
|
CHEMBRDG-BB 7118966 is an inhibitor of Bromodomain-containing protein 4 (human).
|
TQ0253 |
PLX51107
|
1627929-55-8
|
99.75%
|
|
PLX51107 is a potent and selective BET inhibitor (Kds: 1.6, 2.1, 1.7, and 5 nM for BRD2-BD1, BRD3-BD1, BRD4-BD1, and BRDT-BD1).
|
T41180 |
JQAD1
|
2417097-18-6
|
99.75%
|
|
JQAD1 is a potent and selective histone acetyltransferase EP300 degrader (PROTAC®; DC50≤ 31.6 nM); comprises an EP300 inhibitor, A485, joined by a linker to a ce...
|
T10521 |
ODM-207
|
1801503-93-4
|
99.73%
|
|
ODM-207 (BET-IN-4) is a potent BRD4 inhibitor.
|
T40229 |
SR-0813
|
2597186-19-9
|
99.72%
|
|
SR-0813 is a potent and selective inhibitor of the YEATS domain in ENL/AF9. It has an IC 50 of 25 nM and EC 50 of 205 nM for the ENL YEATS domain and an IC 50 of...
|
T6939 |
PFI-3
|
1819363-80-8
|
99.71%
|
|
PFI-3 is a selective chemical inhibitor for SMARCA (2/4) (Kd = 89 nM)and PBI (5) bromodomains which may result in the delay and prevention of breast cancer.
|
T2442 |
CPI203
|
202591-23-9
|
99.71%
|
|
CPI203 (CPI 203) is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
|
T5435 |
ARV-771
|
1949837-12-0
|
99.69%
|
|
ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and B...
|
T10616 |
BRM/BRG1 ATP Inhibitor-1
|
2270879-17-7
|
99.68%
|
|
BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2...
|
T10641 |
C-82
|
1422253-37-9
|
99.66%
|
|
C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.
|