Home Tools
Log in
Cart

Epigenetic Reader Domain

Epigenetic reader domains can be thought of as effector proteins that recognize and are recruited to specific epigenetic marks.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T9568 SGC-SMARCA-BRDVIII 1997319-84-2 99.85%
SGC-SMARCA-BRDVIII
SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respect...
T7856 Naphthol AS-E 92-78-4 99.85%
Naphthol AS-E
Naphthol AS-E (nAS-E) is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.
T6908 NSC 228155 113104-25-9 99.84%
NSC 228155
NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.
T8774 MS7972 352553-42-5 99.84%
MS7972
MS7972 is CREBBP inhibitor that blocks human p53 and CREB binding protein association. MS7972 can almost completely block this BRD interaction at 50 μM
T9194 UMB298 2266569-73-5 99.83%
UMB298
UMB298 is a potent and selective CBP/P300 bromodomain inhibitor. UMB298 inhibits BRD4 with IC50 of 5193nM.
T60079 GNE-064 1997321-20-6 99.81%
GNE-064
GNE-064 is a selective, orally active and highly soluble inhibitor of SMARCA4, SMARCA2 and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC50 of 0.035 μ...
T15441 GSK8573 1693766-04-9 99.81%
GSK8573
GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).
T9541 CTB 451491-47-7 99.80%
CTB
CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells.
T17311 (+)-JQ1 PA 2115701-93-2 99.8%
(+)-JQ1 PA
(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1(IC50 of 10.4 nM).
T5318 666-15 1433286-70-4 99.77%
666-15
666-15 (CREB inhibitor) is a potent and selective CREB inhibitor (IC50: 81 nM).
T8609 6-Bromo-3-methyl-1,4-dihydroquinazolin-2-one 328956-24-7 99.76%
6-Bromo-3-methyl-1,4-dihydroquinazolin-2-one
CHEMBRDG-BB 7118966 is an inhibitor of Bromodomain-containing protein 4 (human).
TQ0253 PLX51107 1627929-55-8 99.75%
PLX51107
PLX51107 is a potent and selective BET inhibitor (Kds: 1.6, 2.1, 1.7, and 5 nM for BRD2-BD1, BRD3-BD1, BRD4-BD1, and BRDT-BD1).
T41180 JQAD1 2417097-18-6 99.75%
JQAD1
JQAD1 is a potent and selective histone acetyltransferase EP300 degrader (PROTAC®; DC50≤ 31.6 nM); comprises an EP300 inhibitor, A485, joined by a linker to a ce...
T10521 ODM-207 1801503-93-4 99.73%
ODM-207
ODM-207 (BET-IN-4) is a potent BRD4 inhibitor.
T40229 SR-0813 2597186-19-9 99.72%
SR-0813
SR-0813 is a potent and selective inhibitor of the YEATS domain in ENL/AF9. It has an IC 50 of 25 nM and EC 50 of 205 nM for the ENL YEATS domain and an IC 50 of...
T6939 PFI-3 1819363-80-8 99.71%
PFI-3
PFI-3 is a selective chemical inhibitor for SMARCA (2/4) (Kd = 89 nM)and PBI (5) bromodomains which may result in the delay and prevention of breast cancer.
T2442 CPI203 202591-23-9 99.71%
CPI203
CPI203 (CPI 203) is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
T5435 ARV-771 1949837-12-0 99.69%
ARV-771
ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and B...
T10616 BRM/BRG1 ATP Inhibitor-1 2270879-17-7 99.68%
BRM/BRG1 ATP Inhibitor-1
BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2...
T10641 C-82 1422253-37-9 99.66%
C-82
C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.
SGC-SMARCA-BRDVIII
T9568
SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respect...
Naphthol AS-E
T7856
Naphthol AS-E (nAS-E) is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.
NSC 228155
T6908
NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.
MS7972
T8774
MS7972 is CREBBP inhibitor that blocks human p53 and CREB binding protein association. MS7972 can almost completely block this BRD interaction at 50 μM
UMB298
T9194
UMB298 is a potent and selective CBP/P300 bromodomain inhibitor. UMB298 inhibits BRD4 with IC50 of 5193nM.
GNE-064
T60079
GNE-064 is a selective, orally active and highly soluble inhibitor of SMARCA4, SMARCA2 and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC50 of 0.035 μ...
GSK8573
T15441
GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).
CTB
T9541
CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells.
(+)-JQ1 PA
T17311
(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1(IC50 of 10.4 nM).
666-15
T5318
666-15 (CREB inhibitor) is a potent and selective CREB inhibitor (IC50: 81 nM).
6-Bromo-3-methyl-1,4-dihydroquinazolin-2-one
T8609
CHEMBRDG-BB 7118966 is an inhibitor of Bromodomain-containing protein 4 (human).
PLX51107
TQ0253
PLX51107 is a potent and selective BET inhibitor (Kds: 1.6, 2.1, 1.7, and 5 nM for BRD2-BD1, BRD3-BD1, BRD4-BD1, and BRDT-BD1).
JQAD1
T41180
JQAD1 is a potent and selective histone acetyltransferase EP300 degrader (PROTAC®; DC50≤ 31.6 nM); comprises an EP300 inhibitor, A485, joined by a linker to a ce...
ODM-207
T10521
ODM-207 (BET-IN-4) is a potent BRD4 inhibitor.
SR-0813
T40229
SR-0813 is a potent and selective inhibitor of the YEATS domain in ENL/AF9. It has an IC 50 of 25 nM and EC 50 of 205 nM for the ENL YEATS domain and an IC 50 of...
PFI-3
T6939
PFI-3 is a selective chemical inhibitor for SMARCA (2/4) (Kd = 89 nM)and PBI (5) bromodomains which may result in the delay and prevention of breast cancer.
CPI203
T2442
CPI203 (CPI 203) is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
ARV-771
T5435
ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and B...
BRM/BRG1 ATP Inhibitor-1
T10616
BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2...
C-82
T10641
C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.
1 2 3 4 5 6 7 8 9 10 11 12 13 14
TargetMol