T5130 |
DBET6
|
1950634-92-0
|
98.76%
|
|
dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.
|
T15784 |
LP99
|
1808951-93-0
|
98.74%
|
|
LP99 is an epigenetic probe. LP99 disrupts the binding of BRD7 and BRD9 to chromatin in cells. LP99 is an effective and selective inhibitor of the BRD7 and BRD9 ...
|
T9221 |
UNC926 hydrochloride
|
1782573-49-2
|
98.71%
|
|
UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor.
|
T12943 |
SNDX-5613
|
2169919-21-3
|
98.7%
|
|
SNDX-5613 is a potent and specific inhibitor of Menin-MLL(Ki of 0.149 nM and a cell based IC50 of 10-20 nM). SNDX-5613 can be used for the research of MLL-rearra...
|
T9749 |
FHD-286
|
2671128-05-3
|
98.7%
|
|
FHD-286 is an inhibitor of BRM/BRG1 ATPase and can be used for studies on the treatment of BAF-related disorders such as acute myeloid leukemia.
|
T2237 |
ICG001
|
847591-62-2
|
98.63%
|
|
ICG001 (PRI-724 isomer) antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with ...
|
T6889 |
MI-136
|
1628316-74-4
|
98.63%
|
|
MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced.
|
T10879 |
CPI-0610 carboxylic acid
|
1380089-81-5
|
98.62%
|
|
CPI-0610 carboxylic acid is an effective and selective small molecule inhibitor of bromine domain and outer end (BET) protein as a ligand of PROTAC target protei...
|
T8658 |
NEO2734
|
2081072-29-7
|
98.56%
|
|
NEO2734 (EP31670) is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).
|
T3624 |
A-366
|
1527503-11-2
|
98.53%
|
|
A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than...
|
T69691 |
Pocenbrodib
|
2304372-79-8
|
98.48%
|
|
Pocenbrodib (FT-7051) is a potent inhibitor of the bromodomain of the CBP/p300 family with potential antitumour activity and is palatable for cancer research.
|
T9703 |
GSK778
|
2451862-42-1
|
98.42%
|
|
GSK778 is a potent and selective inhibitor of BD1 bromodomain such as BRD2 BD1 (IC50s = 75 nM), BRD3 BD1 (IC50s = 41 nM), BRD4 BD1 (IC50s = 41 nM), and BRDT BD1 ...
|
T19935 |
XD14
|
1370888-71-3
|
98.4%
|
|
XD14 is an inhibitor of BET bromodomain (Kd of 160 nM, 170 nM, 380 nM, 490 nM, 830 nM and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2), res...
|
T3504 |
AZD5153 6-Hydroxy-2-naphthoic acid
|
1869912-40-2
|
98.36%
|
|
AZD5153 6-Hydroxy-2-naphthoic acid (AZD5153) is a potent triazolopyridazine-based Bromodomain (BRD4) and Extraterminal (BET) inhibitor used in cancer treatments....
|
T2110 |
(+)-JQ-1
|
1268524-70-4
|
98.36%
|
|
(+)-JQ-1 (JQ1) is a BET bromine domain inhibitor that inhibits BRD4 (1/2) (IC50=77/33 nM) with specificity and reversibility. (+)-JQ-1 induces cell autophagy and...
|
T77912 |
Tz-Thalidomide
|
2087490-42-2
|
98.34%
|
|
Tz-Thalidomide is a tetrazine-modified Thalidomide (E3 ligase ligand) with some affinity for BRD4.
|
T6021 |
GSK1324726A
|
1300031-52-0
|
98.34%
|
|
GSK1324726A (I-BET726) is a greatly specific inhibitor of BET family proteins for BRD2(IC50=41 nM), BRD3(IC50=31 nM), and BRD4 (IC50=22 nM).
|
T14547 |
JWG-071
|
2250323-50-1
|
98.33%
|
|
JWG-071, the first reported chemical probe for ERK5 kinase selectivity, is a BET-selective inhibitor with a 1 μM BRD4 IC that enhances both ERK5 activity and BRD...
|
T14073 |
A-485
|
1889279-16-6
|
98.32%
|
|
A-485 is a potent and selective catalytic p300/CBP inhibitor(IC50s of 9.8 nM and 2.6 nM for p300 and CBP, respectively).
|
T9373 |
DCH36_06
|
593273-05-3
|
98.32%
|
|
DCH36_06 ((5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione) as a bona fide is a potent p30...
|