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Drug Metabolite

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom oxygenations, reductions, and dehydrogenations, heteroatom dealkylations, hydroxylations, can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T11986 Mebeverine acid 475203-77-1 99.66%
Mebeverine acid
Mebeverine acid (Mebeverine metabolite Mebeverine acid) is a secondary metabolite of Mebeverine and can be used as a marker of oral exposure to Mebeverine.
T35688 MTIC 3413-72-7 99.51%
MTIC
MTIC is the active metabolite of Temozolomide (TMZ) with anticancer and antitumor activity and is used in the study of melanoma.3'-Sialyllactose (3'-SL) sodium i...
T5539 GS-443902 1355149-45-9
GS-443902
GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at lea...
T78069 RPR132595A hydrochloride 98%
RPR132595A hydrochloride
RPR132595A (NPC) hydrochloride, an active metabolite of CPT-11, is produced via cytochrome P-450 3A4 (CYP3A4) metabolism and is ultimately eliminated via urinary...
T78130 N-Methyl Palbociclib 571189-51-0 98%
N-Methyl Palbociclib
N-Methyl Palbociclib is an impurity of the orally active selective CDK4 and CDK6 inhibitor Palbociclib (PD 0332991).
T78136 Perindopril acyl-β-D-glucuronide 120398-66-5 98%
Perindopril acyl-β-D-glucuronide
Perindopril acyl-β-D-glucuronide is a metabolite of the ACE inhibitor perindopril [1].
T78547 2-Phenyl-2-(2-pyridyl)acetonitrile 5005-36-7 98%
2-Phenyl-2-(2-pyridyl)acetonitrile
2-Phenyl-2-(2-pyridyl)acetonitrile represents the principal metabolite of the antigastric agent SC 15396, produced by the supernatant fraction of rat liver homog...
T78589 3-Hydroxycarbofuran 16655-82-6 98%
3-Hydroxycarbofuran
3-Hydroxycarbofuran, a principal metabolite of Carbofuran, acts as a reversible inhibitor of acetylcholinesterase (AChE) [1].
T78595 3-Hydroxyphenazepam 70030-11-4 98%
3-Hydroxyphenazepam
3-Hydroxyphenazepam, an active metabolite of Cinazepam, acts as a GABAA receptor agonist. This compound has the ability to inhibit synaptosomal transporter-media...
T80022 (R)-tert-OMe-byakangelicin 89560-97-4 98%
(R)-tert-OMe-byakangelicin
(R)-tert-OMe-byakangelicin, a furanocoumarin, exhibits inhibitory effects on liver drug metabolizing enzyme (DME) activity and can be isolated from the immature ...
T80635 Gentisuric acid 25351-24-0 98%
Gentisuric acid
Gentisuric acid, an Aspirin metabolite and a substrate of α-amidating monooxygenase (PAM), mitigates DNA damage induced by Mitomycin C. [1] [2]
T80658 Quercetin 7-glucuronide 38934-20-2 98%
Quercetin 7-glucuronide
Quercetin 7-glucuronide (Quercetin 7-O-β-glucuronide), a Quercetin metabolite found in Madagascarian Uncarina species, has the capability to inhibit LDL oxidatio...
T82599 DDC 3′-O-β-D glucuronide 98%
DDC 3′-O-β-D glucuronide
Compound 5, DDC 3′-O-β-D-glucuronide, is a drug metabolite with properties that inhibit the fibrillization and oligomerization of Aβ42, suggesting its potential ...
T36896 6α-hydroxy Paclitaxel 153212-75-0 98%
6α-hydroxy Paclitaxel
6α-hydroxy Paclitaxel (6α-OH-PTX) is a major metabolite of the anticancer compound paclitaxel and is partially cytotoxic.
T0617 Nicotinamide N-oxide 1986-81-8 99.9%
Nicotinamide N-oxide
Nicotinamide N-oxide (Nicotinamide 1-oxide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD...
T8183 Deslanoside 17598-65-1 99.89%
Deslanoside
Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry ...
T2149 Vinburnine 4880-88-0 99.86%
Vinburnine
Vinburnine (Eburnalritardo) is a vasodilator. Vinburnine is a vinca alkaloid and a metabolite of vincamine.
T67905 GS-829845 1257705-09-1 99.78%
GS-829845
GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-life t...
T20723 LGE-899 1221722-10-6 99.77%
LGE-899
LGE-899 (Sonidegib metabolite M48) is a main metabolite of Sonidegib which is an inhibitor of the hedgehog pathway. The Tmax of LGE-899(60 h) is much longer than...
TN1742 Homovanillyl alcohol 2380-78-1 99.74%
Homovanillyl alcohol
Homovanillyl alcohol is a biological metabolite of Hydroxytyrosol. Hydroxytyrosol is a phenolic compound that is present in virgin olive oil (VOO) and wine. Homo...
Mebeverine acid
T11986
Mebeverine acid (Mebeverine metabolite Mebeverine acid) is a secondary metabolite of Mebeverine and can be used as a marker of oral exposure to Mebeverine.
MTIC
T35688
MTIC is the active metabolite of Temozolomide (TMZ) with anticancer and antitumor activity and is used in the study of melanoma.3'-Sialyllactose (3'-SL) sodium i...
GS-443902
T5539
GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at lea...
RPR132595A hydrochloride
T78069
RPR132595A (NPC) hydrochloride, an active metabolite of CPT-11, is produced via cytochrome P-450 3A4 (CYP3A4) metabolism and is ultimately eliminated via urinary...
N-Methyl Palbociclib
T78130
N-Methyl Palbociclib is an impurity of the orally active selective CDK4 and CDK6 inhibitor Palbociclib (PD 0332991).
Perindopril acyl-β-D-glucuronide
T78136
Perindopril acyl-β-D-glucuronide is a metabolite of the ACE inhibitor perindopril [1].
2-Phenyl-2-(2-pyridyl)acetonitrile
T78547
2-Phenyl-2-(2-pyridyl)acetonitrile represents the principal metabolite of the antigastric agent SC 15396, produced by the supernatant fraction of rat liver homog...
3-Hydroxycarbofuran
T78589
3-Hydroxycarbofuran, a principal metabolite of Carbofuran, acts as a reversible inhibitor of acetylcholinesterase (AChE) [1].
3-Hydroxyphenazepam
T78595
3-Hydroxyphenazepam, an active metabolite of Cinazepam, acts as a GABAA receptor agonist. This compound has the ability to inhibit synaptosomal transporter-media...
(R)-tert-OMe-byakangelicin
T80022
(R)-tert-OMe-byakangelicin, a furanocoumarin, exhibits inhibitory effects on liver drug metabolizing enzyme (DME) activity and can be isolated from the immature ...
Gentisuric acid
T80635
Gentisuric acid, an Aspirin metabolite and a substrate of α-amidating monooxygenase (PAM), mitigates DNA damage induced by Mitomycin C. [1] [2]
Quercetin 7-glucuronide
T80658
Quercetin 7-glucuronide (Quercetin 7-O-β-glucuronide), a Quercetin metabolite found in Madagascarian Uncarina species, has the capability to inhibit LDL oxidatio...
DDC 3′-O-β-D glucuronide
T82599
Compound 5, DDC 3′-O-β-D-glucuronide, is a drug metabolite with properties that inhibit the fibrillization and oligomerization of Aβ42, suggesting its potential ...
6α-hydroxy Paclitaxel
T36896
6α-hydroxy Paclitaxel (6α-OH-PTX) is a major metabolite of the anticancer compound paclitaxel and is partially cytotoxic.
Nicotinamide N-oxide
T0617
Nicotinamide N-oxide (Nicotinamide 1-oxide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD...
Deslanoside
T8183
Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry ...
Vinburnine
T2149
Vinburnine (Eburnalritardo) is a vasodilator. Vinburnine is a vinca alkaloid and a metabolite of vincamine.
GS-829845
T67905
GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-life t...
LGE-899
T20723
LGE-899 (Sonidegib metabolite M48) is a main metabolite of Sonidegib which is an inhibitor of the hedgehog pathway. The Tmax of LGE-899(60 h) is much longer than...
Homovanillyl alcohol
TN1742
Homovanillyl alcohol is a biological metabolite of Hydroxytyrosol. Hydroxytyrosol is a phenolic compound that is present in virgin olive oil (VOO) and wine. Homo...
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TargetMol