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Dehydrogenase

A dehydrogenase (also called DH or DHase in the literature) is an enzyme belonging to the group of oxidoreductases that oxidizes a substrate by reducing an electron acceptor, usually NAD+/NADP+ or a flavin coenzyme such as FAD or FMN. They also catalyze the reverse reaction, for instance alcohol dehydrogenase not only oxidizes ethanol to acetaldehyde in animals but also produces ethanol from acetaldehyde in yeast.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T17224 VER-246608 1684386-71-7 98.88%
VER-246608
VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK...
T2057 BVT 2733 376640-41-4 98.84%
BVT 2733
BVT 2733 is a new, non-steroidal, isoform-specific inhibitor of 11β-HSD1.
T2121 SW033291 459147-39-8 98.78%
SW033291
SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.
T64347 ALDH1A3-IN-3 18962-05-5 98.74%
ALDH1A3-IN-3
ALDH1A3-IN-3 (compound 16) is a potent inhibitor of ALDH1A3, with an IC50 of 0.26 μM. ALDH1A3-IN-3 is also a good ALDH3A1 substrate. ALDH1A3-IN-3 can be used for...
T11029 HDHODH-IN-5 2029049-77-0 98.70%
hDHODH-IN-5
hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH, IC50 = 0.91 μM).
T2447 AZD7545 252017-04-2 98.69%
AZD7545
AZD7545 is a potent PDHK inhibitor.
T8640 G6PDi-1 2457232-14-1 98.69%
G6PDi-1
G6PDi-1 is an effective G6PD inhibitor. It depletes NADPH and decreases inflammatory cytokine production.
T9394 CHIKV-IN-2 2361289-44-1 98.67%
CHIKV-IN-2
CHIKV-IN-2 shows inhibitory activity against a cellular target Dihydroorotate Dehydrogenase (DHODH), which interacts with various viruses and regulate their repl...
T11027 DHODH-IN-4 1148125-93-2 98.65%
DHODH-IN-4
DHODH-IN-4 is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor. The IC50 values of PfDHODH and HsDHODH are 4 μM and 0.18 μM, resp...
T9594 BI-187004 1303515-32-3 98.63%
BI-187004
BI-187004 is an 11β-hydroxysteroid dehydrogenase 1 inhibitor.
T16510 PF-915275 857290-04-1 98.62%
PF-915275
The dose-dependent effect of PF-915275 on the conversion of cortisone to cortisol in primary human and monkey hepatocytes (EC50: 20 and 100 nM, respectively). PF...
T77579 JC2-11 937820-89-8 98.6%
JC2-11
JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical ...
T0245 RS 61443 115007-34-6 98.58%
RS 61443
RS 61443 (Mycophenolate mofetil) is an immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH)
T13100 TC HSD 21 330203-01-5 98.5%
TC HSD 21
TC HSD 21 is a potent and highly selective inhibitor of 17β-hydroxysteroid dehydrogenase type 3 (IC50 = 14 nM).
T11765 KPLH1130 906669-07-6 98.43%
KPLH1130
KPLH1130, a specific pyruvate dehydrogenase kinase (PDK) inhibitor, enhances glucose tolerance in mice fed a high-fat diet (HFD). It effectively hinders macropha...
T23533 WIN 18446 1477-57-2 98.41%
WIN 18446
inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2)
T5S0620 3-Dehydrotrametenolic acid 29220-16-4 98.39%
3-Dehydrotrametenolic acid
1. 3-Dehydrotrametenolic acid can be a potential anticancer agent against H-ras transformed tumor. 2. Dehydrotrametenolic acid is a promising candidate for a new...
T3175 LDHA-IN-4 1370290-34-8 98.17%
LDHA-IN-4
LDHA-IN-4 (AZ33) is an LDHA inhibitor. Binding affinity to 6-His-tagged human LDHA (2 to 322 amino acid residue) expressed in Escherichia coli BL21 (DE3) cells b...
T3604 Sodium dichloroacetate 2156-56-1 98.17%
Sodium dichloroacetate
Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has ...
T9003 CVT-11127 1018674-83-3 98.15%
CVT-11127
CVT-11127 is an StearoylCoA Desaturase-1 (SCD1) inhibitor.
VER-246608
T17224
VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK...
BVT 2733
T2057
BVT 2733 is a new, non-steroidal, isoform-specific inhibitor of 11β-HSD1.
SW033291
T2121
SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.
ALDH1A3-IN-3
T64347
ALDH1A3-IN-3 (compound 16) is a potent inhibitor of ALDH1A3, with an IC50 of 0.26 μM. ALDH1A3-IN-3 is also a good ALDH3A1 substrate. ALDH1A3-IN-3 can be used for...
hDHODH-IN-5
T11029
hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH, IC50 = 0.91 μM).
AZD7545
T2447
AZD7545 is a potent PDHK inhibitor.
G6PDi-1
T8640
G6PDi-1 is an effective G6PD inhibitor. It depletes NADPH and decreases inflammatory cytokine production.
CHIKV-IN-2
T9394
CHIKV-IN-2 shows inhibitory activity against a cellular target Dihydroorotate Dehydrogenase (DHODH), which interacts with various viruses and regulate their repl...
DHODH-IN-4
T11027
DHODH-IN-4 is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor. The IC50 values of PfDHODH and HsDHODH are 4 μM and 0.18 μM, resp...
BI-187004
T9594
BI-187004 is an 11β-hydroxysteroid dehydrogenase 1 inhibitor.
PF-915275
T16510
The dose-dependent effect of PF-915275 on the conversion of cortisone to cortisol in primary human and monkey hepatocytes (EC50: 20 and 100 nM, respectively). PF...
JC2-11
T77579
JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical ...
RS 61443
T0245
RS 61443 (Mycophenolate mofetil) is an immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH)
TC HSD 21
T13100
TC HSD 21 is a potent and highly selective inhibitor of 17β-hydroxysteroid dehydrogenase type 3 (IC50 = 14 nM).
KPLH1130
T11765
KPLH1130, a specific pyruvate dehydrogenase kinase (PDK) inhibitor, enhances glucose tolerance in mice fed a high-fat diet (HFD). It effectively hinders macropha...
WIN 18446
T23533
inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2)
3-Dehydrotrametenolic acid
T5S0620
1. 3-Dehydrotrametenolic acid can be a potential anticancer agent against H-ras transformed tumor. 2. Dehydrotrametenolic acid is a promising candidate for a new...
LDHA-IN-4
T3175
LDHA-IN-4 (AZ33) is an LDHA inhibitor. Binding affinity to 6-His-tagged human LDHA (2 to 322 amino acid residue) expressed in Escherichia coli BL21 (DE3) cells b...
Sodium dichloroacetate
T3604
Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has ...
CVT-11127
T9003
CVT-11127 is an StearoylCoA Desaturase-1 (SCD1) inhibitor.
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TargetMol