DNA Alkylation

DNA alkylation refers to the addition of alkyl groups to specific bases, resulting in alkylation products such as O2‐alkylthymine, O4‐alkylthymine, O6‐methylguanine and O6‐ethylguanine, which cause DNA mutations.

Cat. No.	Product name	CAS No.	Purity
T11056	DLK-IN-1	1620574-24-4	98%
T11056	DLK-IN-1 is a selective oral active inhibitor of bisleucine zipper kinase (DLK, MAP3K12) with Ki of 3 nM. DLK-IN-1 is active in the Alzheimer's disease model, re...
T11440	GNE-8505	1620573-48-9	98%
T11440	GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).
T12813L	Seco-Duocarmycin SA	144667-38-9	98%
T12813L	Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.
T19300	Duocarmycin Analog	372954-15-9	98%
T19300	Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin.
T3091	Carmustine	154-93-8	99.97%
T3091	Carmustine (bis-chloroethylnitrosourea) is a cell-cycle phase nonspecific alkylating antineoplastic agent.
T1601	Lomustine	13010-47-4	99.86%
T1601	Lomustine (NSC-79037) is an alkylating agent of value against both hematologic malignancies and solid tumors.
T1241	Altretamine	645-05-6	99.84%
T1241	Altretamine (ENT-50852) is an alkylating agent with antineoplastic activity.
T0923	Busulfan	55-98-1	99.77%
T0923	Busulfan (Busulphan) is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully...
T6798	Tretazicar	21919-05-1	99.7%
T6798	CB1954(Tretazicar (NSC-115829)), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and ...
T2495	Lomeguatrib	192441-08-0	99.62%
T2495	Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
T21297	Miriplatin hydrate	250159-48-9	99.6%
T21297	Miriplatin hydrate (SM-11355 (hydrate)) (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC). Mi...
T0975	Chlorambucil	305-03-3	99.58%
T0975	Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cyc...
T6057	URMC-099	1229582-33-5	99.32%
T6057	URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
T17159	Treosulfan	299-75-2	99.26%
T17159	Treosulfan (Treosulphan) is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
T11120	Duocarmycin TM	157922-77-5	99.15%
T11120	Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.
T1507	Streptozocin	18883-66-4	98.89%
T1507	Streptozocin (NSC-85998) is an antibiotic that induces DNA methylation. Streptozocin is toxic to insulin-producing pancreatic islet B-cells and is commonly used ...
T3707	GNE-3511	1496581-76-0	98.64%
T3707	GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.
T26978	CEP-40125	1456608-94-8	98.05%
T26978	CEP-40125 (RXDX-107) is a DNA alkylating agent for the study of advanced solid tumors.
T15771	Lobaplatin	135558-11-1	98.00%
T15771	Lobaplatin (D-19466) (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent w...
T7539	O6-Benzylguanine	19916-73-5	98%
T7539	O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.