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COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T0726 Benzydamine hydrochloride 132-69-4 98%
Benzydamine hydrochloride
Benzydamine hydrochloride (AF864), a locally-acting nonsteroidal anti-inflammatory drug, has local anaesthetic and analgesic properties.
T0184 Fenoprofen calcium dihydrate 53746-45-5 98%
Fenoprofen calcium dihydrate
Fenoprofen calcium is a propionic acid derivative that is used as a non-steroidal anti-inflammatory agent.
TC0036 Compound Lup-20(29)-en-3-yl acetate TC0036 98%
Compound Lup-20(29)-en-3-yl acetate
Lupeol acetate, a derivative of Lupeol, inhibits the progression of rheumatoid arthritis by downregulating TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B.
TQ0180 Chebulagic acid 23094-71-5 98%
Chebulagic acid
Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.
T2878 Ginsenoside Rd 52705-93-8 98%
Ginsenoside Rd
Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.
T0441 Pasiniazid 2066-89-9 98%
Pasiniazid
Pasiniazid (Paraniazide) is an anti-TB and anti-leprosy drug.
T4643 TFAP 1011244-68-0 98%
TFAP
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) is a selective cyclooxygenase-1 (COX-1) inhibitor
T2S0618 β-Elemonic Acid 28282-25-9 98%
β-Elemonic Acid
β-Elemonic Acid (3-Oxotirucallenoic Acid) exhibits anti-inflammatory effects. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apop...
T0961 Trometamol 77-86-1 98%
Trometamol
Trometamol (Tromethamine) is a proton acceptor used to treat acidemia. It inhibits both isoforms of cyclooxygenases (COX1 and COX2), thereby blocking the convers...
TN1308 6-Hydroxyflavanone 4250-77-5 98%
6-Hydroxyflavanone
6-Hydroxyflavanone, a compound extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxyge...
T1212 Ketorolac tromethamine salt 74103-07-4 98%
Ketorolac tromethamine salt
Ketorolac tromethamine salt (Ketorolac tris salt) non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2with anti-inflammatory, analgesic, and ant...
T76717 Serplulimab 2231029-82-4 98%
Serplulimab
Serplulimab (HLX 10) is a humanized monoclonal anti-antibody to PD-1. Serplulimab has antitumor activity and can be used in small cell lung cancer and esophageal...
T76742 Emapalumab 1709815-23-5 98%
Emapalumab
Emapalumab (NI-0501) is an IgG1 monoclonal antibody that humanizes human monoclonal antibodies against interferon gamma, blocking its binding to cell surface rec...
T76760 Sifalimumab 1006877-41-3 98%
Sifalimumab
Sifalimumab (MEDI-545) is a monoclonal antibody that targets IFNα and suppresses abnormal immune activity by binding to interferon-alpha.Sifalimumab is used for ...
T60053 Hamaline 2411677-02-4 98%
Hamaline
Hamaline (9-(4-chlorobenzyl)-6-methoxy-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indole) is a substrate-selective cyclooxygenase-2 (COX-2) inhibitor.
T0055 Glafenine 3820-67-5 98%
Glafenine
Glafenine (Glafenin), a non-narcotic analgesic agent, is a non-steroidal anti-inflammatory drug (NSAID), and widely used for the therapy of pains of various orig...
T1191L Metamizole sodium 68-89-3 98%
Metamizole sodium
Metamizole sodium (Analgin) is a drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.
TN1377 α-Spinasterol 481-18-5 98%
α-Spinasterol
α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α...
T77433 Feladilimab 2252518-85-5 98%
Feladilimab
Feladilimab (GSK3359609) is an IgG4 monoclonal antibody that is an ICOS agonist. Feladilimab binds to ICOS-expressing T cells, induces IFNγ, and increases PD-1/L...
T19679 Benoxaprofen 51234-28-7 98%
Benoxaprofen
Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.
Benzydamine hydrochloride
T0726
Benzydamine hydrochloride (AF864), a locally-acting nonsteroidal anti-inflammatory drug, has local anaesthetic and analgesic properties.
Fenoprofen calcium dihydrate
T0184
Fenoprofen calcium is a propionic acid derivative that is used as a non-steroidal anti-inflammatory agent.
Compound Lup-20(29)-en-3-yl acetate
TC0036
Lupeol acetate, a derivative of Lupeol, inhibits the progression of rheumatoid arthritis by downregulating TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B.
Chebulagic acid
TQ0180
Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.
Ginsenoside Rd
T2878
Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.
Pasiniazid
T0441
Pasiniazid (Paraniazide) is an anti-TB and anti-leprosy drug.
TFAP
T4643
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) is a selective cyclooxygenase-1 (COX-1) inhibitor
β-Elemonic Acid
T2S0618
β-Elemonic Acid (3-Oxotirucallenoic Acid) exhibits anti-inflammatory effects. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apop...
Trometamol
T0961
Trometamol (Tromethamine) is a proton acceptor used to treat acidemia. It inhibits both isoforms of cyclooxygenases (COX1 and COX2), thereby blocking the convers...
6-Hydroxyflavanone
TN1308
6-Hydroxyflavanone, a compound extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxyge...
Ketorolac tromethamine salt
T1212
Ketorolac tromethamine salt (Ketorolac tris salt) non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2with anti-inflammatory, analgesic, and ant...
Serplulimab
T76717
Serplulimab (HLX 10) is a humanized monoclonal anti-antibody to PD-1. Serplulimab has antitumor activity and can be used in small cell lung cancer and esophageal...
Emapalumab
T76742
Emapalumab (NI-0501) is an IgG1 monoclonal antibody that humanizes human monoclonal antibodies against interferon gamma, blocking its binding to cell surface rec...
Sifalimumab
T76760
Sifalimumab (MEDI-545) is a monoclonal antibody that targets IFNα and suppresses abnormal immune activity by binding to interferon-alpha.Sifalimumab is used for ...
Hamaline
T60053
Hamaline (9-(4-chlorobenzyl)-6-methoxy-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indole) is a substrate-selective cyclooxygenase-2 (COX-2) inhibitor.
Glafenine
T0055
Glafenine (Glafenin), a non-narcotic analgesic agent, is a non-steroidal anti-inflammatory drug (NSAID), and widely used for the therapy of pains of various orig...
Metamizole sodium
T1191L
Metamizole sodium (Analgin) is a drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.
α-Spinasterol
TN1377
α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α...
Feladilimab
T77433
Feladilimab (GSK3359609) is an IgG4 monoclonal antibody that is an ICOS agonist. Feladilimab binds to ICOS-expressing T cells, induces IFNγ, and increases PD-1/L...
Benoxaprofen
T19679
Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.
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TargetMol