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BCL

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T4085 Paris saponin VII 68124-04-9 99.63%
Paris saponin VII
Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
T3867 Alpinetin 36052-37-6 99.61%
Alpinetin
Alpinetin ((-)-alpinetin) has antibacterial activity.Alpinetin has anti-inflammatory activity.Alpinetin can enhance the sensitivity of HepG2 hepatoma cells to th...
T5210 BAI1 335165-68-9 99.58%
BAI1
BAI1 (Bax channel blocker) is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50: 0.52 μM).
TN1406 Dihydrokaempferol 480-20-6 99.51%
Dihydrokaempferol
Dihydrokaempferol (Aromadendrin) is a natural product. It induces apoptosis and inhibits Bcl-2 and Bcl-xL expression, possesses anti-inflammatory, antioxidant, a...
T17247 VU0661013 2131184-57-9 99.46%
VU0661013
VU0661013 is an effective and selective inhibitor of MCL-1.
T6275 Obatoclax Mesylate 803712-79-0 99.38%
Obatoclax Mesylate
Obatoclax Mesylate (GX15-070) is a Bcl-2 antagonist (Ki: 0.22 μM) and can induce apoptosis with up-regulation of Bim, induced cytochrome c release, and activatio...
T7979 2-Hydroxychalcone 644-78-0 99.38%
2-Hydroxychalcone
2-Hydroxychalcone (2-(2-Hydroxybenzal)Acetophenone) can be used as antiparasitic hit compounds when Methoxylated.It can inhibit invasion of triple negative breas...
T9113 Myristicin 607-91-0 99.34%
Myristicin
Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effe...
T2099 ABT-737 852808-04-9 99.3%
ABT-737
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w (EC50s: 78.7/30.3/197.8 nM).
T12629L MIK665 1799631-75-6 99.28%
MIK665
MIK665 (S-64315) (S-64315) has an inhibitory effect on myeloid leukemia.
T38622 Bcl-xL antagonist 2 1235032-75-3 99.26%
Bcl-xL antagonist 2
Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM. Bcl-xL antagonist 2 induces apoptosis in cancer c...
T2453 BAM7 331244-89-4 99.23%
BAM7
BAM 7 is a direct and specific activator of proapoptotic Bax (EC50: 3.3 μM).
TN1891 Lupiwighteone 104691-86-3 99.20%
Lupiwighteone
Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.
T5104 BTSA1 314761-14-3 99.15%
BTSA1
BTSA1 is a BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX...
T1119 Rasagiline 136236-51-6 99.14%
Rasagiline
Rasagiline (AGN1135) is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa and carbidopa in the management of Parkinsons di...
T12186 Navitoclax-piperazine 2143096-93-7 99.11%
Navitoclax-piperazine
Navitoclax-piperazine (ABT-263-piperazine) is an inhibitor of B-cell lymphoma extra large (BCL-XL).
T3697 3',6-Disinapoylsucrose 139891-98-8 99.02%
3',6-Disinapoylsucrose
3',6-Disinapoylsucrose (Disinapoyl sucrose) shows the neuroprotective effect and antidepressive activity in rats.
T6881 LTX-315 1345407-05-7 99%
LTX-315
LTX-315 (Oncopore), the oncolytic peptide, inhibits cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization.
T12824L S55746 1448584-12-0 98.99%
S55746
S55746 (BLC201) is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of 3.9 nM).
T4088 Thymoquinone 490-91-5 98.98%
Thymoquinone
Thymoquinone (NSC 2228) is a compound be found in herbs and spices with anti-inflammatory and anti-oxidant effects.
Paris saponin VII
T4085
Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
Alpinetin
T3867
Alpinetin ((-)-alpinetin) has antibacterial activity.Alpinetin has anti-inflammatory activity.Alpinetin can enhance the sensitivity of HepG2 hepatoma cells to th...
BAI1
T5210
BAI1 (Bax channel blocker) is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50: 0.52 μM).
Dihydrokaempferol
TN1406
Dihydrokaempferol (Aromadendrin) is a natural product. It induces apoptosis and inhibits Bcl-2 and Bcl-xL expression, possesses anti-inflammatory, antioxidant, a...
VU0661013
T17247
VU0661013 is an effective and selective inhibitor of MCL-1.
Obatoclax Mesylate
T6275
Obatoclax Mesylate (GX15-070) is a Bcl-2 antagonist (Ki: 0.22 μM) and can induce apoptosis with up-regulation of Bim, induced cytochrome c release, and activatio...
2-Hydroxychalcone
T7979
2-Hydroxychalcone (2-(2-Hydroxybenzal)Acetophenone) can be used as antiparasitic hit compounds when Methoxylated.It can inhibit invasion of triple negative breas...
Myristicin
T9113
Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effe...
ABT-737
T2099
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w (EC50s: 78.7/30.3/197.8 nM).
MIK665
T12629L
MIK665 (S-64315) (S-64315) has an inhibitory effect on myeloid leukemia.
Bcl-xL antagonist 2
T38622
Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM. Bcl-xL antagonist 2 induces apoptosis in cancer c...
BAM7
T2453
BAM 7 is a direct and specific activator of proapoptotic Bax (EC50: 3.3 μM).
Lupiwighteone
TN1891
Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.
BTSA1
T5104
BTSA1 is a BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX...
Rasagiline
T1119
Rasagiline (AGN1135) is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa and carbidopa in the management of Parkinsons di...
Navitoclax-piperazine
T12186
Navitoclax-piperazine (ABT-263-piperazine) is an inhibitor of B-cell lymphoma extra large (BCL-XL).
3',6-Disinapoylsucrose
T3697
3',6-Disinapoylsucrose (Disinapoyl sucrose) shows the neuroprotective effect and antidepressive activity in rats.
LTX-315
T6881
LTX-315 (Oncopore), the oncolytic peptide, inhibits cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization.
S55746
T12824L
S55746 (BLC201) is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of 3.9 nM).
Thymoquinone
T4088
Thymoquinone (NSC 2228) is a compound be found in herbs and spices with anti-inflammatory and anti-oxidant effects.
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TargetMol