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BCL

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN3152 6-Acetonyldihydrochelerythrine 22864-92-2 98%
6-Acetonyldihydrochelerythrine
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therape...
TN4490 Manassantin B 88497-88-5 98%
Manassantin B
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-EBV ...
T14499 Bax activator-1 1638526-94-9 98%
Bax activator-1
Bax activator-1 (compound 106) is a Bax activator. It induces Bax-dependent tumor cell apoptosis[1].
TN1139 Dehydrocavidine 83218-34-2 98%
Dehydrocavidine
Dehydrocavidine (Dehydrocorydaline) has antitumor activity, it inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activati...
TN3931 Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid 57719-81-0 98%
ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
TN3653 Cimidahurinine 142542-89-0 98%
Cimidahurinine
Cimidahurinine can attenuate Doxorubicin (DOX)-induced cardiotoxicity in a dose-dependent manner with EC50 values of 45.79 uM; it protects against cardiotoxicity...
T10485 PROTAC Bcl2 degrader-1 2378801-85-3 98%
PROTAC Bcl2 degrader-1
PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).
TN2040 Panaxynol 81203-57-8 98%
Panaxynol
Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation.
TN4307 Isolimonexic acid 73904-93-5 98%
Isolimonexic acid
Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth.
T5526 Glycoborinine 233279-39-5 98%
Glycoborinine
Glycoborinine is a potential molecule against cancer cells, it can induce HepG2 apoptosis through the mitochondrial-dependent pathway. Glycoborinine has photo-ac...
T13337 WEHI-539 hydrochloride 2070018-33-4 98%
WEHI-539 hydrochloride
WEHI-539 hydrochloride is a selective Bcl-XL inhibitor (IC50: 1.1 nM).
T13337L WEHI-539 1431866-33-9 98%
WEHI-539
WEHI-539 is a selective Bcl-XL inhibitor (IC50: 1.1 nM).
TN4271 Isochamaejasmine 93859-63-3 98%
Isochamaejasmine
Isochamaejasmine, isolated from S. chamaejasme L., inhibits NF-κB activation. Isochamaejasmine induces leukemia cell apoptosis by inhibiting the activity of Bcl-...
TN3614 Cearoin 52811-37-7 98%
Cearoin
Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
TN2308 Wilfortrine 37239-48-8 98%
Wilfortrine
Wilfortrine can induce liver cancer cell HepG2 apoptosis, but with no effect on the cell cycle, mainly by promoting Bax expression and inhibiting anti-apoptotic ...
TMA0153 Safflor Yellow A 85532-77-0 98%
Safflor Yellow A
Safflor Yellow A protects cultured rat cardiomyocytes against A/R injury, maybe via inhibiting cellular oxidative stress and apoptosis.
T11973 Mcl1-IN-11 2042211-13-0 98%
Mcl1-IN-11
Mcl1-IN-11 (Compound G) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.06 and 4.2 μM, respectively.
T10577 BM 957 1391107-54-2 98%
BM 957
BM 957 is an effective Bcl-2 and Bcl-xL inhibitor (Kis: 1.2 and <1 nM; IC50s: 5.4 and 6.0 nM).
T16043 Metaproterenol 586-06-1 98%
Metaproterenol
Metaproterenol also has anti-inflammatory activity. Metaproterenol is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist (IC50: 68 nM).
TN3486 Bakkenolide IIIa 915289-60-0 98%
Bakkenolide IIIa
Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-κB...
6-Acetonyldihydrochelerythrine
TN3152
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therape...
Manassantin B
TN4490
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-EBV ...
Bax activator-1
T14499
Bax activator-1 (compound 106) is a Bax activator. It induces Bax-dependent tumor cell apoptosis[1].
Dehydrocavidine
TN1139
Dehydrocavidine (Dehydrocorydaline) has antitumor activity, it inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activati...
ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid
TN3931
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
Cimidahurinine
TN3653
Cimidahurinine can attenuate Doxorubicin (DOX)-induced cardiotoxicity in a dose-dependent manner with EC50 values of 45.79 uM; it protects against cardiotoxicity...
PROTAC Bcl2 degrader-1
T10485
PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).
Panaxynol
TN2040
Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation.
Isolimonexic acid
TN4307
Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth.
Glycoborinine
T5526
Glycoborinine is a potential molecule against cancer cells, it can induce HepG2 apoptosis through the mitochondrial-dependent pathway. Glycoborinine has photo-ac...
WEHI-539 hydrochloride
T13337
WEHI-539 hydrochloride is a selective Bcl-XL inhibitor (IC50: 1.1 nM).
WEHI-539
T13337L
WEHI-539 is a selective Bcl-XL inhibitor (IC50: 1.1 nM).
Isochamaejasmine
TN4271
Isochamaejasmine, isolated from S. chamaejasme L., inhibits NF-κB activation. Isochamaejasmine induces leukemia cell apoptosis by inhibiting the activity of Bcl-...
Cearoin
TN3614
Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
Wilfortrine
TN2308
Wilfortrine can induce liver cancer cell HepG2 apoptosis, but with no effect on the cell cycle, mainly by promoting Bax expression and inhibiting anti-apoptotic ...
Safflor Yellow A
TMA0153
Safflor Yellow A protects cultured rat cardiomyocytes against A/R injury, maybe via inhibiting cellular oxidative stress and apoptosis.
Mcl1-IN-11
T11973
Mcl1-IN-11 (Compound G) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.06 and 4.2 μM, respectively.
BM 957
T10577
BM 957 is an effective Bcl-2 and Bcl-xL inhibitor (Kis: 1.2 and <1 nM; IC50s: 5.4 and 6.0 nM).
Metaproterenol
T16043
Metaproterenol also has anti-inflammatory activity. Metaproterenol is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist (IC50: 68 nM).
Bakkenolide IIIa
TN3486
Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-κB...
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TargetMol