T4496 |
LM22B-10
|
342777-54-2
|
98.19%
|
|
LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.
|
T8427 |
Borussertib
|
1800070-77-2
|
98.18%
|
|
Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt(IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt)
|
TN1215 |
(2S)-2'-Methoxykurarinone
|
270249-38-2
|
98.17%
|
|
(2S)-2'-Methoxykurarinone is isolated from the roots of Sophora flavescens. (2S)-2'-Methoxykurarinone has anti-inflammatory, antipyretic, antidiabetic, and antin...
|
TN1490 |
Chrysoeriol
|
491-71-4
|
98.16%
|
|
Chrysoeriol has antioxidant, antiinflammatory, antitumor, antimicrobial, antiviral, and free radical scavenging activities, it also shows selective bronchodilato...
|
T72968 |
ZINC00640089
|
667880-11-7
|
98.13%
|
|
ZINC00640089 is a selective lipid carrier protein-2 (LCN2) inhibitor. ZINC00640089 inhibited cell proliferation and cell viability, and reduced AKT phosphorylati...
|
TN1461 |
(-)-Butin
|
492-14-8
|
98.07%
|
|
(-)-Butin (Butin) has antioxidant activity, can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction; it at...
|
T4489 |
AKT-IN-1
|
1357158-81-6
|
98.02%
|
|
AKT-IN-1 (AZD-26) is an allosteric AKT inhibitor (IC50: 1.04 μM).
|
T3467 |
Miransertib
|
1313881-70-7
|
98%
|
|
Miransertib (ARQ-092) is an orally bioavailable, selective, and potent allosteric Akt inhibitor.
|
T5574 |
Guggulsterone
|
95975-55-6
|
98%
|
|
Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.
|
T6251 |
PF-04691502
|
1013101-36-4
|
98%
|
|
PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.
|
T2420 |
PHT-427
|
1191951-57-1
|
98%
|
|
PHT-427 (CS-0223) is a dual Akt (Ki: 2.7 μM) and PDPK1 (Ki: 5.2 μM) inhibitor (high-affinity binding for the PH domains of Akt and PDPK1).
|
T5S1632 |
Barlerin
|
57420-46-9
|
98%
|
|
Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced inj...
|
T2274 |
SC79
|
305834-79-1
|
98%
|
|
SC79, a selective Akt activator, may be used to enhance Akt activity in various pathological and physiological conditions.
|
T1961 |
Vistusertib
|
1009298-59-2
|
97.94%
|
|
Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.
|
T2974 |
Cyclovirobuxine D
|
860-79-7
|
97.78%
|
|
Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla.
|
T1920 |
Capivasertib
|
1143532-39-1
|
97.59%
|
|
Capivasertib (AZD5363) (AZD5363) is a new-type orally available inhibitor of the serine/threonine protein kinase AKT (IC50s: 3/7/7 nM for Akt1/2/3).
|
TMA2474 |
δ-Tocotrienol
|
25612-59-3
|
97.38%
|
|
δ-Tocotrienol (Delta-Tocotrienol) is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung...
|
T0392 |
Artemisinin
|
63968-64-9
|
97%
|
|
Artemisinin (Qinghaosu) is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of mala...
|
T6997 |
SU6656
|
330161-87-0
|
97%
|
|
SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
|
T25150 |
BI-69A11
|
1233322-09-2
|
96.97%
|
|
BI-69A11 ((E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one) is a dual AKT and NFkB pathway inhibitor. It enhances the...
|