Akt

Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration.

Cat. No.	Product name	CAS No.	Purity
T6304	AT7867	857531-00-1	99.65%
T6304	AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the...
T13265	Urolithin B	1139-83-9	99.64%
T13265	Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropical frui...
T60564	PI3K/Akt/mTOR-IN-2	2757804-89-8	99.61%
T60564	PI3K/Akt/mTOR-IN-2 is a potent PI3K/AKT/mTOR inhibitor.PI3K/Akt/mTOR-IN-2 has anticancer effects and is selective for MDA-MB-231 cells with an IC50 of 2.29 μM.PI...
T3132	SC66	871361-88-5	99.6%
T3132	SC66 is a AKT inhibitor in HepG2, HA22T/VGH, and PLC/PRF/5 cells (IC50: about 0.75 μg/ml, at 72 h).
T16104	ML-9	105637-50-1	99.6%
T16104	ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibits...
T3729	Ethyl gallate	831-61-8	99.58%
T3729	Ethyl gallate (gallic acid ethyl ester) obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytot...
T6139L	A-674563 2HCl(552325-73-2(fb-2hcl))	T6139L	99.57%
T6139L	A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
T4S0498	Glaucocalyxin A	79498-31-0	99.56%
T4S0498	1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase...
T6849	Uprosertib	1047634-65-0	99.54%
T6849	Uprosertib (GSK2141795) (GSK2141795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 a...
T0033	Miltefosine	58066-85-6	99.51%
T0033	Miltefosine (HePC) is the treatment of visceral and cutaneous leishmaniasis drug , and is proceeding clinical trials for this in several countries. Several medic...
T5S1331	Herbacetin	527-95-7	99.51%
T5S1331	1. Herbacetin induces apoptosis in HepG2 cells, by ROS and PI3K/Akt pathway. 2. Herbacetin suppresses the HGF-induced motility of human breast cancer MDA-MB-231 ...
T9831	MKC-1	125313-92-0	99.46%
T9831	MKC-1 (Ro-31-7453) is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its meta...
T19699	Triciribine phosphate	61966-08-3	99.43%
T19699	Triciribine phosphate (VD 002) is a highly selective AKT inhibitor that induces cell cycle arrest and cysteinyl asparagin-dependent apoptosis, inhibits neovascul...
T13376	YS-49	132836-42-1	99.42%
T13376	YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).
T11928	M2698	1379545-95-5	99.36%
T11928	M2698 (MSC2363318A) is an inhibitor of p70S6K, Akt1 and Akt3 with IC50s of 1 nM. M2698 shows anti-cancer activity.
T3895	Polyphyllin I	50773-41-6	99.36%
T3895	Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, c...
TN1911	Marein	535-96-6	99.34%
TN1911	Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation o...
T2746	Sophocarpine monohydrate	145572-44-7	99.33%
T2746	Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
T2789	Scutellarin	27740-01-8	99.32%
T2789	Scutellarin (Scutellarein-7-glucuronide), an active flavone isolated from Scutellaria baicalensis, can inhibit RANKL-mediated MAPK and NF-κB signaling pathway in...
T2895	Lupeol	545-47-1	99.31%
T2895	Lupeol (Monogynol B) is a novel androgen receptor inhibitor with anti-inflammatory and antioxidant activity.