ALK

Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene.

Cat. No.	Product name	CAS No.	Purity
T1935	LDN193189	1062368-24-4	99.11%
T1935	LDN193189 (LDN-193189) (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for...
T2655	CEP-37440	1391712-60-9	99.01%
T2655	CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
T3041	ALK inhibitor 2	761438-38-4	99%
T3041	ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.
T77726	INCB-000928	2173389-57-4	98.93%
T77726	Zilurgisertib (INCB-000928) is a selective and potent ALK 2 inhibitor for the study of cancer and MF anemia.
T6337	RepSox	446859-33-2	98.8%
T6337	RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM). R...
T3031	A 83-01	909910-43-6	98.76%
T3031	A 83-01 (ALK5 Inhibitor IV) is an inhibitor of the TGF-β type I receptors ALK5, ALK4, and ALK7 (IC50=12/45/7.5 nM). A 83-01 promotes the reprogramming of mouse f...
T38752	EW-7195	1352609-28-9	98.76%
T38752	EW-7195 is a selective and potent inhibitor of ALK5 (TGFβR1) with an IC50 value of 4.83 nM.EW-7195 has an affinity for ALK5 that is more than 300-fold higher tha...
T16153	MS4078	2229036-62-6	98.74%
T16153	MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.
T2462	SB-505124	694433-59-5	98.74%
T2462	SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5.
T3550	X-376	1365267-27-1	98.72%
T3550	X-376 (Ensartinib) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic...
T8108	Blu-782	2141955-96-4	98.59%
T8108	Blu-782 (ALK2-IN-1) is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM)
T10285	ALK inhibitor 1	761436-81-1	98.55%
T10285	ALK inhibitor 1 is a selective ALK kinase inhibitor.
T1763	SB 525334	356559-20-1	98.39%
T1763	SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).
T4015	HG-14-10-04	1356962-34-9	98.36%
T4015	HG-14-10-04 is a potent and specific ALK inhibitor.
T13416	ZX-29	2254805-62-2	98.32%
T13416	ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces ...
T9224	CH5424802 analog	1256577-71-5	98.31%
T9224	CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.
T1943	ML347	1062368-49-3	98.3%
T1943	ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.
T35896	AZ 12799734	1117684-36-2	98.23%
T35896	AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.
T15572	IN-1130	868612-83-3	98.08%
T15572	IN-1130 is a selective inhibitor of ALK5 with IC50 values of 5.3 nM, 36 nM, and 4.3 μM for phosphorylation of ALK5-mediated Smad3, ALK5 phosphorylation of casein...
T15612	JH-VIII-157-02	1639422-97-1	98.02%
T15612	JH-VIII-157-02 is an inhibitor of ALK and inhibits echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) with IC50s of 2 nM for EML4-ALK G1202R, EML4-A...