ALRN-6924 is a novel dual MDM4 and MDM2 inhibitor.

Sulanemadlin (ALRN-6924) is a potent peptidomimetic macrocycle that serves as an inhibitor of the p53-MDM2 and p53-MDMX protein-protein interactions. It is capable of inhibiting either or both of these interactions, positioning it as a valuable tool for cancer research [1].

cis-Entacapone is a metabolite of the catechol-O-methyltransferase (COMT) inhibitor entacapone. It is also a potential impurity found in commercial preparations of entacapone and a degradant of entacapone formed by UV light exposure.