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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9238 | KI-7 | Adenosine Receptor | |
KI-7 is an adenosine A2B receptor positive allosteric modulator. | |||
T68313 | KI-328 | ||
KI-328 is a novel KIT inhibitor. KI-328 shows selective potency against KIT kinase for the in vitro kinase assay, and inhibits the growth of wild-type (Wt)- and mutant-KIT-expressing cells, while it has little potency ag... | |||
T11758L | KI696 | Nrf2 | |
KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2. | |||
T2446 | KI8751 | EGFR , VEGFR , FGFR , PDGFR , c-Kit | |
KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM. | |||
T11758 | KI696 isomer | Nrf2 | |
KI696 isomer is an isomer of KI696, a low affinity probe for the study of immune and metabolic diseases. | |||
T6347 | Ki16198 | LPA Receptor , LPL Receptor | |
Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively, shows weaker inhibition for LPA2, no activ... | |||
T6108 | Ki16425 | Debio 0719 | LPA Receptor , LPL Receptor |
Ki16425 (Debio 0719) is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively. | |||
T69162 | Ki23057 | ||
Ki23057 is a a FGFR2 inhibitor, which enhances the chemosensitivity of drug-resistant gastric cancer cell lines when used in combination with chemotherapeutic drugs. Ki23057 might be therapeutically promising for treatin... | |||
T4315 | Ki20227 | c-Fms , VEGFR , CSF-1R , PDGFR , c-Kit | |
Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRβ(IC50: 451/217 nM), respectively. | |||
T2126 | MK-5046 | Bombesin Receptor | |
MK-5046 is a novel BRS-3 agonist, binding to BRS-3 with high affinity (mouse Ki = 1.6 nM, human Ki = 25 nM). | |||
T15712 | Laropiprant | MK-0524 | Prostaglandin Receptor |
Laropiprant (MK-0524) is a potent and selective antagonist of prostaglandin D2 (PGD2) receptor (DP) such as and DP/DP1 receptor(Ki = 0.57 nM) and TP Receptor(Ki = 2.95 nM). | |||
T39284 | EST73502 HCl | Opioid Receptor | |
EST73502 is an agonist of μ-opioid receptor(Ki = 64 nM) agonist and an antagonist of σ1 receptor (Ki = 118 nM). EST73502 displays antinociceptive activity. | |||
T27800 | LAS38096 | LAS 38096,LAS-38096 | Adenosine Receptor |
LAS38096 is an A2B adenosine receptor antagonist (Ki : 17 nM) that is potent, selective and efficient . | |||
T1749 | AL 082D06 | D-06,AL082D06 | Glucocorticoid Receptor |
AL 082D06 (D-06), a selective nonsteroidal glucocorticoid receptor (GR) antagonist (Ki: 210 nM), exhibits outstanding selectivity against AR, ER, MR and PR(Ki > 10 uM). | |||
TQ0084 | Lumateperone Tosylate | ITI-007 | Dopamine Receptor , 5-HT Receptor |
lumateperone Tosylate (ITI-007) is a 5-HT2A receptor antagonist (Ki: 0.54 nM), a SERT blocker (Ki: 61 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki: 32 nM). | |||
T14069 | A-3 hydrochloride | CaMK , Casein Kinase , PKA , PKC | |
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectiv... | |||
T14151 | AKR1C1-IN-1 | NADPH | |
AKR1C1-IN-1 is a human 20α-hydroxysteroid dehydrogenase (AKR1C1) inhibitor (Ki: 4 nM for AKR1C1). | |||
T5587 | CGP71683 hydrochloride | CGP71683A | Neuropeptide Y Receptor |
CGP71683 hydrochloride (CGP71683A) is a competitive neuropeptide Y5 receptor antagonist (Ki: 1.3 nM) and shows no obvious activity at Y1 receptor (Ki >4000 nM) and Y2 receptor (Ki: 200 nM) in cell membranes. | |||
T2420 | PHT-427 | PHT 427,CS-0223 | Apoptosis , Akt , PDK |
PHT-427 (CS-0223) is a dual Akt (Ki: 2.7 μM) and PDPK1 (Ki: 5.2 μM) inhibitor (high-affinity binding for the PH domains of Akt and PDPK1). | |||
T15682 | L-371,257 | Oxytocin Receptor , Vasopressin Receptor | |
L-371,257 is a competitive antagonist of oxytocin receptor with pA2 of 8.4 and Ki of 19 nM. L-371,257 shows a Ki of 3.7 nM for vasopressin receptor 1a. | |||
T4607 | CAY 10465 | CAY10465,CAY10465 Exclusive | AhR , Aryl Hydrocarbon Receptor |
CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM). | |||
T41247 | Thioperamide maleate | MR-12842 maleate | Histamine Receptor |
Thioperamide maleate (MR-12842 maleate) is an effective and selective antagonist of H3 receptor (Ki = 4.3 nM) for inhibition of [3H]histamine synthesis (Ki = 31 nM). | |||
T2009 | SB-3CT | MMP | |
SB-3CT is a potent and specific gelatinase inhibitor for MMP-2(Ki=13.9 nM) and MMP-9(Ki=600 nM). | |||
T10261 | AGN 196996 | Others , Retinoid Receptor , Autophagy | |
AGN 196996 is a potent and selective inhibitor of RARα (Ki: 2 nM).AGN 196996 has very low affinity for RARβ and RARγ, with a Ki of 1087 nM and 8523 nM, respectively. | |||
T2017 | U-104 | NSC-213841,MST-104 | Carbonic Anhydrase |
U-104 (NSC-213841) is an effective carbonic anhydrase (CA) inhibitor for CA IX( Ki=45.1 nM) and CA XII(Ki=4.5 nM). | |||
T1865 | S1RA | E-52862 | Sigma receptor |
S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating significant selectivity over the sigma-2 receptor (σ2R, Ki > 1000 nM). | |||
T2373 | Vipadenant | CEB-4520,BIIB-014 | Adenosine Receptor |
Vipadenant (CEB-4520)(BIIB-014) is an adenosine A2a antagonist with Ki of 1.3 nM; less potent for A1(Ki=69 nM). | |||
T17183 | TY-52156 | S1P Receptor , LPL Receptor | |
TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM). | |||
T23782 | Benzolamide | CL-11366,W 1803,CL 11366,CL11366,W-1803 | Carbonic Anhydrase |
Benzolamide (CL 11366) inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons. | |||
T35347 | Et-29 | NRD167 | Sirtuin |
Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM. | |||
T7343 | PF-04979064 | PI3K , mTOR | |
PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively). | |||
T15595L | IRL-1620 acetate | IRL-1620 acetate(142569-99-1 free base) | Endothelin Receptor |
IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM. | |||
T4523 | TP-3654 | Pim | |
TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM). | |||
T15270 | Fananserin | RP 62203 | Dopamine Receptor , 5-HT Receptor |
Fananserin is an effective, selective and oral active antagonist of 5-HT2 (Ki = 0.37 nM for the rat 5-HT2A). Fananserin is an antagonist of human D4 receptor (Ki = 2.93 nM). | |||
T12306 | OMDM-5 | Cannabinoid Receptor , Endogenous Metabolite , TRP/TRPV Channel | |
OMDM-5 is a selective anandamide cellular uptake (ACU)inhibitor(Ki of 4.8 μM). | |||
T37696 | NOS1-IN-1 | nNOS Inhibitor I | NOS |
NOS1-IN-1(nNOS Inhibitor I) is a potent, selective and cell permeable nNOS inhibitor (Ki: 120 nM).NOS1-IN-1 has a Ki value of 39 μM for eNOS and 325 μM for iNOS.NOS1-IN-1 can be used for the study of neurological disorde... | |||
T15364 | G-1 | Estrogen Receptor/ERR , GPR | |
G-1 is a nonsteroidal, high-affinity and selective GPR30 agonist (Ki: 11 nM). | |||
T2688 | LY310762 | LY310762 HCl | 5-HT Receptor |
LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM. | |||
T6417 | BML-190 | Indomethacin morpholinylamide,IMMA,BML 190 | Cannabinoid Receptor |
BML-190 (Indomethacin morpholinylamide) is a specific CB2 receptor inverse agonist (Ki: 435 nM), with 50-fold selectivity over CB1 receptor. | |||
T22959 | M-Chlorophenylbiguanide hydrochloride | 1-(3-Chlorophenyl)biguanidehydrochloride | 5-HT Receptor |
5-HT3 receptor agonist | |||
T6022 | LY404039 | pomaglumetad | Glucocorticoid Receptor , GluR |
LY404039 (pomaglumetad) is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM). | |||
T7389 | G15 | Estrogen Receptor/ERR | |
G15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM) | |||
T10876 | CPA inhibitor | Carboxypeptidase inhibitor | Carboxypeptidase |
CPA inhibitor (Carboxypeptidase inhibitor) is a potent carboxypeptidase A (CPA) inhibitor with a Ki of 0.32 μM. | |||
T7292 | FITM | GluR | |
FITM is a potent negative allosteric modulator of mGlu1 receptor(Ki : 2.5 nM). | |||
T28531 | Facinicline hydrochloride | RG3487 | 5-HT Receptor , AChR |
Facinicline hydrochloride (RG3487) is both a novel nicotinic alpha-7 receptor (alpha7nAChR) partial agonist (Ki = 6 nM) and an antagonist of 5-HT3(Ki = 1.2 nM). Facinicline hydrochloride improves cognition and sensorimot... | |||
T10053 | 5HT6-ligand-1 | 5-HT Receptor | |
5HT6-ligand-1 is an orally active ligand of 5-HT6 receptor (Ki = 1.43 nM). | |||
T11799 | L-745870 hydrochloride | Dopamine Receptor | |
L-745870 hydrochloride has excellent brain penetration. L-745870 hydrochloride is a high-affinity, selective and orally active human dopamine D4 receptor antagonist with a Ki of 0.43 nM, and considerably weaker D2 recept... | |||
T6458 | CYC-116 | VEGFR , FLT , CDK , S6 Kinase , Aurora Kinase | |
CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 ... | |||
T21667 | FAUC-365 | FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide,FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide | Dopamine Receptor |
FAUC-365 is a D3 dopamine receptor agonist. | |||
T6585 | SAR405838 | MI773,MI 773,MI-77301,MI-773 | Mdm2 , E1/E2/E3 Enzyme |
MI-773 (SAR405838 (MI 773)) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4S2354 | Dimethylfraxetin | Fraxetin dimethyl ether,6,7,8-Trimethoxycoumarin | Carbonic Anhydrase |
Dimethylfraxetin (6,7,8-Trimethoxycoumarin) is a Carbonic anhydrase inhibitor(Ki:0.0097 μM) | |||
T2922 | Phlorizin | Floridzin,NSC 2833,Phloridzin | ATPase , SGLT |
Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) . | |||
T8182 | Guanfu base A | Guan-fu base A | P450 , Potassium Channel , HER |
Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current. | |||
T9605 | Sangivamycin | BA-90912,NSC 65346 | Nucleoside Antimetabolite/Analog , PKC |
Sangivamycin (NSC-65346) is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers. | |||
T8260 | 4',5-Dihydroxyflavone | Lipoxygenase , Glucosidase | |
4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM). | |||
T2209 | Serotonin hydrochloride | 5-HT hydrochloride,5-HT HCl,Serotonin HCl,5-Hydroxytryptamine hydrochloride | 5-HT Receptor , Endogenous Metabolite , Transferase |
Serotonin hydrochloride (Serotonin HCl) is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=44 μM). | |||
TN5752 | Isorhapontin | Antifungal | |
Isorhapontin inhibits the activity of Trichoderma cellobiohydrolase I (Ki = 57.2 μM) and Trichoderma endoglucanase I. Isorhapontin shows antifungal activity. | |||
TN1160 | 1,2,3,6-Tetragalloylglucose | 1,2,3,6-Tetra-O-galloyl-β-D-glucose,TeGG | LDL , UGT |
1,2,3,6-Tetragalloylglucose (TeGG) has antioxidative activity, it also shows the most potent anticomplement activity (IC50 = 34 microM). 1,2,3,6-Tetragalloylglucose is also a potent inhibitor of UDP glucuronosyltransfera... | |||
T8373 | 6-Diazo-5-oxo-L-nor-Leucine | DON,L-6-Diazo-5-oxonorleucine,Diazooxonorleucine | Influenza Virus , Glutaminase , Antibacterial , Antibiotic |
6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine) is an antagonist of glutaminases (Ki : 6 μM). It is an antineoplastic antibiotic produced by an unidentified species of Streptomyces from Peruvian soil. | |||
T4429 | Rauwolscine hydrochloride | Corynanthidine hydrochloride,α-Yohimbine hydrochloride,Isoyohimbine hydrochloride | Adrenergic Receptor |
Rauwolscine hydrochloride (Isoyohimbine hydrochloride) , a natural alkaloid, is a specific and reversible α2-adrenergic receptor antagonist (Ki: 12 nM) [1]. It is a stereoisomer of yohimbine, which potently antagonizes b... | |||
T15686 | L-741626 | 3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole | Dopamine Receptor |
L-741626 (3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole) is a selective antagonist of D2 dopamine receptor (Ki: 2.4, 100, and 220 nM for human D2, D3 and D4 receptors respectively). | |||
TN1472 | Cassiaside | Beta-Secretase , BACE | |
Cassiaside is a naphthyl ketone glycoside that inhibits BACE1 (IC50= 4.45 μM; Ki=9.85 μM).Cassiaside exhibits significant hepatoprotective effects against galactosamine injury and has potential anti-Alzheimer's disease (... | |||
T5648 | Purpurin | 1,2,4-Trihydroxyanthraquinone,Hydroxylizaric acid,Verantin | MAO , Antibacterial , Antibiotic , Antifungal |
Purpurin (Verantin) was a reversible and competitive inhibitor of MAO-A with a Ki value of 0.422μM. it exhibits anti-angiogenic, antifungal, antibiotic, and antioxidative activities. | |||
TN1016 | Kukoamine A | NF-κB , Lipoxygenase , DNA/RNA Synthesis , Parasite | |
Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidative stress and apoptosis after whole-brain irradiation (WBI) i... | |||
TN1120 | Osthenol | MAO , Monoamine Oxidase | |
Osthenol is a natural product, and is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM).It shows antitumor-promoting activity, it also has antifungal and antibacterial activ... | |||
T0687 | Simvastatin | MK-0733,MK 733 | Apoptosis , Mitophagy , Ferroptosis , HMG-CoA Reductase , Autophagy |
Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cholesterol, and is also used for the prevention of cardiovasc... | |||
T10941 | D-Ribonolactone | Endogenous Metabolite , Antibacterial | |
D-Ribonolactone is sugar lactone and an inhibitor of β-galactosidase of Escherichia coli (Ki : 26 Mm). | |||
T6856 | Halofuginone | Tempostatin,empostatin,RU-19110 | Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad |
Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal. | |||
T5081 | Adenine monohydrochloride hemihydrate | Adenine hydrochloride hydrate,6-Aminopurine hydrochloride hydrate | Endogenous Metabolite , Adenosine Receptor |
Adenine monohydrochloride hemihydrate is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). It inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor a... | |||
TN3013 | 4,5-Dimethoxycanthin-6-one | Methylnigakinone | P450 , Antibacterial , PDE |
4,5-Dimethoxycanthin-6-one is an alkaloid isolated from Picrasma quassioides BENNET (Simaroubaceae).4,5-Dimethoxycanthin-6-one was isolated from Picrasma quassioides BENNET (Simaroubaceae) with antimicrobial activity.4,5... | |||
TN1736 | Hibifolin | Adenosine deaminase | |
Hibifolin is a flavonol glycoside natural product,is a potential inhibitor of adenosine deaminase (Ki of 49.92 μM). Hibifolin protects neurons against beta-amyloid-induced neurotoxicity. | |||
T6430 | Calcifediol | U 32070E,25-hydroxy Vitamin D3,RO 8-8892 | Endogenous Metabolite |
Calcifediol (U 32070E)(Ki of 3.9 μM), a major circulating metabolite of vitamin D3, works as a competitive inhibitor. It (ED50=2 nM)also inhibits PTH secretion and mRNA. | |||
T4000 | (±)-Equol | Equol,(R,S)-Equol | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Drug Metabolite |
(±)-Equol ((R,S)-Equol) is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (ER) agonist activity of the naturally occu... | |||
T10191L | 7-Chlorokynurenic acid | 7-chloro-4-hydroxy-2-carboxyquinoline,7-CKA | GluR , NMDAR |
7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake... | |||
TN1650 | Friedelin | P450 , NOS , Caspase , Prostaglandin Receptor | |
Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities. | |||
TN3748 | D-Asparagine | H-D-Asn-OH | Others , Endogenous Metabolite |
D-Asparagine (H-D-Asn-OH) is a source of nitrogen for yeast strains. D-Asparagine is a competitive inhibitor of L-Asparagine hydrolysis (Ki = 0.24 mM). | |||
T2144 | Tacrolimus | Fujimycin,FK506,FR900506 | Phosphatase , Others , Antibacterial , Antibiotic , mTOR , Autophagy |
Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the activity of the calcium/calmodulin-dependent protein phosphatase. | |||
TN1849 | Kuwanon H | GPR , Bombesin Receptor | |
Kuwanon H, and possibly kuwanon G also, are specific antagonists for the gastrin-releasing peptide (GRP) -preferring receptor and can be useful for studying the physiological and pathological role of GRP. | |||
TQ0296L | N-Nornuciferine hydrochloride(4846-19-9 free base) | N-Nornuciferine hydrochloride | P450 |
N-Nornuciferine hydrochloride(4846-19-9 free base) (N-Nornuciferine hydrochloride) is an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50: 3.76 μM, Ki: 2.34 μM). | |||
T2926 | Schizandrin A | P450 , Virus Protease , Autophagy | |
Schisandrin A, a primary active component extracted from the traditional Eastern medicine Schisandra chinensis, inhibits CYP3A activity, with an IC50 of 6.60 μM and a Ki of 5.83 μM. | |||
T13539 | Allopurinol riboside | Others , Endogenous Metabolite , Parasite , Drug Metabolite | |
Allopurinol riboside is a metabolite of allopurinol with potency against parasites. Allopurinol riboside competitively inhibits the action of purine nucleoside phosphorylase on inosine with a Ki of 277 μM. | |||
T2770 | Gentiopicroside | Gentiopicrin | P450 , HCV Protease |
Gentiopicroside (Gentiopicrin), a naturally occurring iridoid glycoside, extracted from Gentiana manshurica Kitag, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22.8 μM for CYP2A6; has antianti-inflammatorya... | |||
T7671 | Myosmine | Others , AChR | |
Myosmine is a minor tobacco alkaloid that is structurally related to nicotine. | |||
T4024 | Norharmane | 2-Azacarbazole,2,9-Diazafluorene,β-Carboline | DNA , Endogenous Metabolite , Monoamine Oxidase |
Norharmane (β-Carboline) is a natural β-carboline first isolated from plants of the Zygophyllaceae family. | |||
T5S0669 | Bergamottin | 5-Geranoxypsoralen,Bergamotine,Bergaptin | P450 |
1. Bergamottin (5-Geranoxypsoralen) can significantly reduce blood glucose and increase glucose tolerance and insulin sensitivity in KK-A<sup>y</sup>diabetic mice. | |||
T14853 | Cabergoline | FCE-21336 | Dopamine Receptor , 5-HT Receptor , Autophagy |
Cabergoline (FCE-21336) is an ergot derived-dopamine D2-like receptor agonist. It has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).Cabergoline permits rapid and effective hormonal a... | |||
T5564 | Tricarballylic acid | β-Carboxyglutaric acid,1,2,3-Propanetricarboxylic acid,Carballylic acid,Propane-1,2,3-tricarboxylic acid | aconitase , Mitochondrial Metabolism |
Tricarballylic acid (Carballylic acid) is an inhibitor of aconitase. | |||
T5568 | H-Tyr(3-I)-OH | 3-Iodo-L-tyrosine | Endogenous Metabolite |
H-Tyr(3-I)-OH (3-Iodo-L-tyrosine) is an inhibitor of tyrosine hydroxylase (Ki = 0.39 M) and an intermediate in the synthesis of thyroid hormones | |||
T5S0994 | N-Methylcytisine | Caulophylline | Others , AChR |
1. N-Methylcytisine (Caulophylline)'s nicotinic receptors have high affinity (KD = 5 nM)to nAChR from squid optical ganglia. 2. N-Methylcytisine and N, N-dimethylcytisine did not displace 14C-tubocurarine at a concentrat... | |||
T2O2744 | Alpha-Naphthoflavone | 7,8-benzoflavone | Aromatase |
alpha-Naphthoflavone (7,8-benzoflavone), a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM. | |||
T4S0051 | Coptisine sulfate | Indoleamine 2,3-Dioxygenase (IDO) | |
1. Coptisine sulfate has growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program. | |||
T7472 | 7-Hydroxyflavone | P450 | |
7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2.with anti-inflammatory activity | |||
TN2268 | Tetrahydromagnolol | Cannabinoid Receptor , GPR , GABA Receptor | |
Tetrahydromagnolol can activate cannabinoid (CB) receptors. | |||
T1717 | Alpha-Mangostin | α-Mangostin,Mangostin | Apoptosis , Virus Protease , Dehydrogenase , Reactive Oxygen Species , Antibacterial , Antifungal |
alpha-Mangostin (Mangostin) is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree. | |||
T3149 | Salvianolic Acid C | Others , P450 | |
Salvianolic Acid C is extracted from the root of Salvia miltiorrhiza, a perennial plant in the genus Salvia. | |||
T1310 | 2-Thiouracil | Thiouracil,Deracil | Thyroid hormone receptor(THR) , NO Synthase |
2-Thiouracil (Deracil) is a thiolated uracil derivative that is a known anti-hyperthyroid agent. | |||
T11218 | ε-Viniferin | epsilon-Viniferin | P450 |
ε-Viniferin (epsilon-Viniferin) a dimer of resveratrol, shows the inhibitory effects of epsilon-viniferin on human CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2E1, CYP3A4 and CYP4A activities. | |||
T1711 | Harmine | Telepathine | MAO , 5-HT Receptor , DYRK |
Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala. | |||
T3736 | Olivetol | 5-Pentylresorcinol,5-n-Amylresorcinol | Cannabinoid Receptor , P450 , IκB/IKK |
Olivetol (5-n-Amylresorcinol) (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in various syntheses of tetrahydrocannabinol. Olivetol has an... | |||
T4S0145 | Corylifol A | Corylinin | hCE , STAT , UGT |
1. Corylifol A (Corylinin) displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. 2. Corylifol A and Biochanin A can be the potentia... | |||
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Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01827 | CD30/TNFRSF8 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
CD30/TNFRSF8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P28908-1. | |||
TMPY-04113 | KRAS Protein,Human,Recombinant(G12D & Q61H, His) | Human | E. coli |
KRAS Protein,Human,Recombinant(G12D & Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01116-2. | |||
TMPY-05737 | CD30/TNFRSF8 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
CD30/TNFRSF8 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.92 kDa and the accession number is Q60846. | |||
TMPY-05443 | CD30/TNFRSF8 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
CD30/TNFRSF8 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.6 kDa and the accession number is Q60846. | |||
TMPY-04116 | KRAS Protein,Human,Recombinant(G12C & Q61H, His) | Human | E. coli |
KRAS Protein,Human,Recombinant(G12C & Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01116-2. | |||
TMPY-06056 | KRAS Protein, Human, Recombinant (G12D, His) | Human | E. coli |
KRAS Protein, Human, Recombinant (G12D, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22 kDa and the accession number is P01116-2. | |||
TMPY-01888 | KRAS Protein,Human, Recombinant (Q61H, His) | Human | E. coli |
KRAS Protein,Human, Recombinant (Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22.5 kDa and the accession number is P01116-2. | |||
TMPY-03614 | PSME3 Protein, Human, Recombinant (His) | Human | E. coli |
PSME3, also known as PA28-gamma, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is comp... | |||
TMPJ-01436 | MKI67 Protein, Human, Recombinant (GST) | Human | E. coli |
MKI67 also also known as Ki67, is a 350-400 kDa nuclear protein that belongs to a molecular group comprised of mitotic chromosome-associated proteins. MKI67 contains 1 FHA domain and plays a key role in cell proliferatio... | |||
TMPY-05471 | CD30/TNFRSF8 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
CD30/TNFRSF8 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.2 kDa and the accession number is P28908-1. | |||
TMPY-05118 | CD30/TNFRSF8 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
CD30/TNFRSF8 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.9 kDa and the accession number is P28908-1. | |||
TMPY-06282 | CD30/TNFRSF8 Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | HEK293 Cells |
CD30/TNFRSF8 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 67.02 kDa and the accession number is P28908-1. | |||
TMPY-06430 | CD30/TNFRSF8 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
CD30/TNFRSF8 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 41.74 kDa and the accession number is P28908-1. | |||
TMPJ-00510 | KRAS Protein, Human, Recombinant (G12C, His) | Human | E. coli |
KRAS Protein, Human, Recombinant (G12C, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 26 KDa and the accession number is AAH13572.1. | |||
TMPJ-00511 | KRAS Protein, Human, Recombinant (G12V, His) | Human | E. coli |
KRAS Protein, Human, Recombinant (G12V, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 25-30 KDa and the accession number is AAH13572.1. | |||
TMPK-00078 | CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (His), FITC-Labeled | Human | HEK293 Cells |
CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7. CD70 is a cytokine that binds to CD27. Plays a role in T-cell activa... | |||
TMPK-00666 | CD27 Ligand/CD70 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7. CD70 is a cytokine that binds to CD27. Plays a role in T-cell activa... | |||
TMPK-00080 | CD27 Ligand/CD70 Trimer Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7. CD70 is a cytokine that binds to CD27. Plays a role in T-cell activa... | |||
TMPY-03105 | Ki67/MKI67 Protein, Human, Recombinant (GST) | Human | E. coli |
MKI67 contains 1 FHA domain and plays a key role in cell proliferation. During interphase, the MKI67 antigen can be exclusively detected within the cell nucleus, whereas in mitosis most of the protein is relocated to the... | |||
TMPJ-00341 | CD30/TNFRSF8 Protein, Human, Recombinant (aa 19-379, hFc) | Human | HEK293 Cells |
CD30/TNFRSF8 Protein, Human, Recombinant (aa 19-379, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-120 KDa and the accession number is P28908. | |||
TMPK-00079 | CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (His) | Human | HEK293 Cells |
CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7. CD70 is a cytokine that binds to CD27. Plays a role in T-cell activa... | |||
TMPJ-00342 | CD30/TNFRSF8 Protein, Human, Recombinant (aa 19-379, His) | Human | HEK293 Cells |
CD30/TNFRSF8 Protein, Human, Recombinant (aa 19-379, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 60-95 KDa and the accession number is P28908. | |||
TMPJ-00343 | CD30/TNFRSF8 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
CD30/TNFRSF8 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 90-120 KDa and the accession number is P28908. | |||
TMPJ-00340 | CD30/TNFRSF8 Protein, Human, Recombinant (aa 19-379, His & Avi), Biotinylated | Human | HEK293 Cells |
CD30/TNFRSF8 Protein, Human, Recombinant (aa 19-379, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 60-90 KDa and the accession number is P28908. | |||
TMPJ-00240 | CAMK1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Calcium/Calmodulin-Dependent Protein Kinase Type 1 (CAMK1) belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, and CaMK subfamily. CAMK1 contains one protein kinase domain and widely expressed.... | |||
TMPK-01450 | HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01432 | HLA-A*11:01&B2M&KRAS G12A (VVVGAAGVGK) Tetramer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01451 | HLA-C 03:04&B2M&KRAS G12D (GADGVGKSAL) Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01433 | HLA-A*11:01&B2M&KRAS G12C (VVVGACGVGK) Tetramer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01428 | HLA-A*11:01&B2M&KRAS G12D (VVGADGVGK) Monomer Protein, Human, MHC (His & Avi) | Human | E. coli |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01404 | HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Monomer Protein, Human, MHC (E. coli, His & Avi), Biotinylated | Human | E. coli |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01526 | HLA-A*03:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01453 | HLA-A*03:01&B2M&KRAS G12V (VVVGAVGVGK) Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01457 | HLA-A*11:01&B2M&KRAS G12A (VVVGAAGVGK) Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01461 | HLA-A*11:01&B2M&KRAS G12S (VVVGASGVGK) Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01439 | HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled | Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01537 | HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPY-06345 | KRAS Protein, Human, Recombinant (His & Avi), Biotinylated | Human | E. coli |
KRAS Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with His and Avi tag. The predicted molecular weight is 23.78 kDa and the accession number is P01116-2. | |||
TMPK-01402 | HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer Protein, Human, MHC (E. coli, His & Avi), Biotinylated | Human | E. coli |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01408 | HLA-A*02:01&B2M&KRAS G12V (KLVVVGAVGV) Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | E. coli |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01427 | HLA-A*11:01&B2M&KRAS G12D (VVGADGVGK) Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | E. coli |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01403 | HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer Protein, Human, MHC (E. coli, His & Avi) | Human | E. coli |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01430 | HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Monomer Protein, Human, MHC (E. coli, His & Avi) | Human | E. coli |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01399 | HLA-A*11:01&B2M&KRAS WT (VVGAGGVGK) Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | E. coli |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01464 | HLA-A*11:01&B2M&KRAS G12R (VVVGARGVGK) Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01443 | HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Monomer Protein, Human, MHC (His & Avi), FITC-Labeled | Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01488 | HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01528 | HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01471 | HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Monomer Protein, Human, MHC (His & Avi), FITC-Labeled | Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01458 | HLA-A*11:01&B2M&KRAS G12A (VVVGAAGVGK) Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
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