Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 31.00 | |
5 mg | In stock | $ 51.00 | |
10 mg | In stock | $ 89.00 | |
25 mg | In stock | $ 179.00 | |
50 mg | In stock | $ 269.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 57.00 |
Description | PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively). |
Targets&IC50 | mTOR:1.42 nM (Ki), PI3Kγ:0.111 nM (Ki) , PI3Kα:0.13 nM (Ki) , PI3Kδ:0.122 nM (Ki) |
In vivo | PF-04979064 was tested against human class I PI3K isoforms α, γ, and δ, with PI3Kα Ki of 0.130 nM, PI3Kγ Ki of 0.111 nM, and PI3Kδ Ki of 0.122 nM.PF-04979064 was progressed to rat in vivo PK studies and exhibited robust PK profile: Vdss = 5.23 L/kg, Cl = 19.3 mL/min/kg, T1/2 = 1.85 h, and F % = 61%. |
Molecular Weight | 446.5 |
Formula | C24H26N6O3 |
CAS No. | 1220699-06-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (24.64 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PF-04979064 1220699-06-8 PI3K/Akt/mTOR signaling mTOR PI3K Inhibitor Phosphoinositide 3-kinase Mammalian target of Rapamycin PF 04979064 PF04979064 inhibit inhibitor