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MK-5046

Catalog No. T2126 CAS 1022152-70-0

Synonyms: MK5046

MK-5046 is a novel BRS-3 agonist, binding to BRS-3 with high affinity (mouse Ki = 1.6 nM, human Ki = 25 nM).

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MK-5046, CAS 1022152-70-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MK-5046 is a novel BRS-3 agonist, binding to BRS-3 with high affinity (mouse Ki = 1.6 nM, human Ki = 25 nM).
Targets&IC50	BRS-3(hμMan):25 nM(ki), BRS-3(mouse):1.6 nM (ki)
Kinase Assay	Raf-MEK-ERK cascade kinase assay: Non-phosphorylated myelin basic protein (MBP) is coated onto an ELISA plate, and the active form of B-Raf/c-Raf is mixed with unphosphorylated MEK1/MEK2 and ERERK2 in 10 μM ATP and 12.5 mM MgCl2 containing MOPS buffer in the presence of various concentrations of GSK1120212. The phosphorylation of MBP is detected by the anti-phospho-MBP antibody.

Synonyms	MK5046
Molecular Weight	444.381
Formula	C20H18F6N4O
CAS No.	1022152-70-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Guan XM, et al. J Pharmacol Exp Ther. 2011 Feb;336(2):356-364.

Related compound libraries

This product is contained In the following compound libraries：

Fluorochemical Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MK-5046 1022152-70-0 G蛋白偶联受体 Bombesin Receptor MK5046 MK 5046 inhibit Inhibitor inhibitor

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