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PHT-427

Catalog No. T2420 CAS 1191951-57-1

Synonyms: PHT 427, CS-0223

PHT-427 (CS-0223) is a dual Akt (Ki: 2.7 μM) and PDPK1 (Ki: 5.2 μM) inhibitor (high-affinity binding for the PH domains of Akt and PDPK1).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

PHT-427, CAS 1191951-57-1

Pack Size	Availability	Price/USD
10 mg	In stock	$ 39.00
25 mg	In stock	$ 79.00
50 mg	In stock	$ 155.00
100 mg	In stock	$ 263.00
200 mg	In stock	$ 452.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 100%

Purity: 99.77%

Purity: 99.11%

Purity: 98.61%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PHT-427 (CS-0223) is a dual Akt (Ki: 2.7 μM) and PDPK1 (Ki: 5.2 μM) inhibitor (high-affinity binding for the PH domains of Akt and PDPK1).
Targets&IC50	PDK1:5.2 μM(Ki), Akt:2.7 μM(Ki)
Kinase Assay	Surface plasmon resonance (SPR) spectroscopy binding assays: All interaction analyses are performed with a Biacore 2000, Biacore 2000 Control Software v3.2, and BIAevaluation v4.1 analysis software. The PH domain GST-fusion proteins (Akt1, IRS1, and PDK1) are immobilized on a CM5 Sensorchip using Biacore's Amine Coupling Kit to a level of 10,000 Response units (RUs). Small molecule analytes at concentrations ranging from 0.1 to 10 × the predicted KD are injected at a high flow rate (30μL/min). DMSO concentrations in all samples and running buffer are 1% (v/v) or less.

Synonyms	PHT 427, CS-0223
Molecular Weight	409.61
Formula	C20H31N3O2S2
CAS No.	1191951-57-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 41 mg/mL (100 mM)

References and Literature

1. Meuillet EJ, et al. Mol Cancer Ther, 2010, 9(3), 706-717. 2. Moses SA, et al. Cancer Res, 2009, 69(12), 5073-5081.

Citations

1. Huang Q, Ru Y, Luo Y, et al.Identification of a targeted ACSL4 inhibitor to treat ferroptosis-related diseases.Science Advances.2024, 10(13): eadk1200.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Kinase Inhibitor Library Anti-Aging Compound Library Bioactive Compound Library Anti-Obesity Compound Library Anti-Ovarian Cancer Compound Library Stem Cell Differentiation Compound Library Oxidation-Reduction Compound Library Anti-Cancer Metabolism Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PHT-427 1191951-57-1 Apoptosis Cytoskeletal Signaling PI3K/Akt/mTOR signaling Akt PDK Inhibitor PKB CS 0223 CS0223 PHT 427 inhibit CS-0223 PHT427 Protein kinase B inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.