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N-Methylcytisine

Catalog No. T5S0994 CAS 486-86-2

Synonyms: Caulophylline

1. N-Methylcytisine (Caulophylline)'s nicotinic receptors have high affinity (KD = 5 nM)to nAChR from squid optical ganglia. 2. N-Methylcytisine and N, N-dimethylcytisine did not displace 14C-tubocurarine at a concentration of .1 mM, cytisine was the only effective inhibitor of 14C-tubocurarine specific binding (Ki=7 nM).

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N-Methylcytisine, CAS 486-86-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 59.00
5 mg	In stock	$ 129.00
10 mg	In stock	$ 219.00
25 mg	In stock	$ 389.00
50 mg	In stock	$ 573.00
100 mg	In stock	$ 835.00
500 mg	In stock	$ 1,680.00
1 mL * 10 mM (in DMSO)	In stock	$ 137.00

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Purity: 99.83%

Purity: 99.62%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	1. N-Methylcytisine (Caulophylline)'s nicotinic receptors have high affinity (KD = 5 nM)to nAChR from squid optical ganglia. 2. N-Methylcytisine and N, N-dimethylcytisine did not displace 14C-tubocurarine at a concentration of .1 mM, cytisine was the only effective inhibitor of 14C-tubocurarine specific binding (Ki=7 nM).
Targets&IC50	14C-tubocurarine:7 nM(Ki)
Source	Natural Products > Fabaceae > Sophora

Synonyms	Caulophylline
Molecular Weight	204.27
Formula	C12H16N2O
CAS No.	486-86-2

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (134.62 mM)

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

References and Literature

1. Determination of N-methylcytisine in rat plasma by UPLC-MS/MS and its application to pharmacokinetic study[J]. Journal of Chromatography B, 2015, 990:118-124.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Inhibitor Library Traditional Chinese Medicine Monomer Library Anti-Neurodegenerative Disease Compound Library Anti-Alzheimer's Disease Compound Library Bioactive Compound Library Natural Product Library NO PAINS Compound Library Neuronal Signaling Compound Library Traditional Mongolian Medicine Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

N-Methylcytisine 486-86-2 Neuroscience Others AChR NMethylcytisine inhibit Nicotinic acetylcholine receptors nAChR N Methylcytisine Inhibitor Caulophylline inhibitor

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