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Cabergoline

Cabergoline
Cabergoline (FCE-21336) is an ergot derived-dopamine D2-like receptor agonist. It has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).Cabergoline permits rapid and effective hormonal and tumor control by normalizing prolactin-producing pituitary adenomas levels.
Catalog No. T14853Cas No. 81409-90-7
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Purity:99.86%
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Cabergoline

Catalog No. T14853Cas No. 81409-90-7
Cabergoline (FCE-21336) is an ergot derived-dopamine D2-like receptor agonist. It has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).Cabergoline permits rapid and effective hormonal and tumor control by normalizing prolactin-producing pituitary adenomas levels.
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Pack SizePriceAvailabilityQuantity
1 mg$34In Stock
5 mg$77In Stock
10 mg$122In Stock
25 mg$243In Stock
50 mg$449In Stock
100 mg$659In Stock
1 mL x 10 mM (in DMSO)$85In Stock
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Product Introduction

Bioactivity
Description
Cabergoline (FCE-21336) is an ergot derived-dopamine D2-like receptor agonist. It has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).Cabergoline permits rapid and effective hormonal and tumor control by normalizing prolactin-producing pituitary adenomas levels.
In vitro
Cabergoline(10 μM) is used to investigate its neuroprotective effects. MAP2 staining reveals that Cabergoline significantly suppresses the loss of neurons caused by H2O2 incubation. Pretreatment with Cabergoline inhibits H2O2-induced neuronal cell death in a dose-dependent manner. Cabergoline prevents apoptotic cell death following H2O2 exposure [1].
In vivo
Cabergoline demonstrates a longer elimination half-life (63 to 109 hours) compared to other D2-like receptor agonists, offering prolonged clinical benefits from a single dose and potential enhancements in the quality of life for individuals with chronic conditions [1]. It notably reduces the number of rapid eye movement (REM) sleep bouts in female mice, achieving a 67.3% reduction (F(1,11)=12.892, P=0.004) in non-restrained subjects, with the most considerable decrease observed during the dark phase (82.3% reduction). In male mice, Cabergoline significantly lowers baseline Prolactin (PRL) levels by 98.5% (F(1,6)=13.192, P=0.011) to 0.08 ng/mL within two hours post-injection. PRL levels normalize to baseline (5.0±0.60 ng/mL; F(1,6)=0.715, P=0.43) following a seven-day recovery period [2].
AliasFCE-21336
Chemical Properties
Molecular Weight451.6
FormulaC26H37N5O2
Cas No.81409-90-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 32 mg/mL (70.86 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2143 mL11.0717 mL22.1435 mL110.7174 mL
5 mM0.4429 mL2.2143 mL4.4287 mL22.1435 mL
10 mM0.2214 mL1.1072 mL2.2143 mL11.0717 mL
20 mM0.1107 mL0.5536 mL1.1072 mL5.5359 mL
50 mM0.0443 mL0.2214 mL0.4429 mL2.2143 mL

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