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Adenine monohydrochloride hemihydrate

Catalog No. T5081 CAS 6055-72-7

Synonyms: Adenine hydrochloride hydrate, 6-Aminopurine hydrochloride hydrate

Adenine monohydrochloride hemihydrate is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). It inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor and also stimulates GTPγS binding (pEC50 values are 8.54 and 7.21 respectively).

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Adenine monohydrochloride hemihydrate Chemical Structure

Adenine monohydrochloride hemihydrate, CAS 6055-72-7

Pack Size	Availability	Price/USD	Quantity
1 g	In stock	$ 41.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 97.61%

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Description	Adenine monohydrochloride hemihydrate is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). It inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor and also stimulates GTPγS binding (pEC50 values are 8.54 and 7.21 respectively).
Targets&IC50	Adenosine receptor:18 nM (Ki)
In vivo	Procyclidine is used as antiparkinsonian agents because of their anti-cholinergic action is also known to have NMDA antagonist properties. Unlike other NMDA antagonists, this agents-because of their anti-cholinergic action-are devoid of neurotoxic side effects [1].

Synonyms	Adenine hydrochloride hydrate, 6-Aminopurine hydrochloride hydrate
Molecular Weight	189.6
Formula	C5H8ClN5O
CAS No.	6055-72-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (263.71 mM)

References and Literature

1. Gorzalka S, et al. Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues. Mol Pharmacol. 2005 Mar;67(3):955-64. 2. Bender E, et al. Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8573-8.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Human Endogenous Metabolite Library Bioactive Compounds Library Max Human Metabolite Library Natural Product Library for HTS Neurotransmitter Receptor Compound Library Natural Product Library Bioactive Compound Library Neuronal Signaling Compound Library RO5 Drug-like Natural Product Library

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Keywords

Adenine monohydrochloride hemihydrate 6055-72-7 GPCR/G Protein Metabolism Neuroscience Endogenous Metabolite Adenosine Receptor Adenine hydrochloride Hydrate Adenine hydrochloride hydrate Adenine inhibit Inhibitor 6-Aminopurine hydrochloride hydrate Adenine monohydrochloride Hemihydrate 6-Aminopurine hydrochloride Hydrate inhibitor

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