Powder: -20°C for 3 years | In solvent: -80°C for 1 year
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively[1]. A-3 hydrochloride against PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM) and myosin light chain kinase (MLCK) (Ki=7.4 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
5 mg | In stock | $ 61.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 173.00 | |
50 mg | In stock | $ 289.00 | |
100 mg | In stock | $ 463.00 | |
500 mg | In stock | $ 987.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 92.00 |
Description | A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively[1]. A-3 hydrochloride against PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM) and myosin light chain kinase (MLCK) (Ki=7.4 μM). |
Targets&IC50 | PKA:4.3 μM (ki), PKC:47 μM (ki), CK1:80 μM (ki), CK2:5.1 μM (ki) |
In vitro | A-3 hydrochloride inhibits MLC-kinase competitively with respect to ATP and that the Ki value is 7.4 μM, and it is also a competitive inhibitor of cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C, casein kinase I, and casein kinase II, with respect to ATP, exhibits Ki values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively[1]. |
Molecular Weight | 321.22 |
Formula | C12H14Cl2N2O2S |
CAS No. | 78957-85-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (389.14 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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A-3 hydrochloride 78957-85-4 Chromatin/Epigenetic Cytoskeletal Signaling Metabolism Neuroscience Stem Cells Tyrosine Kinase/Adaptors PKC PKA Casein Kinase CaMK Calmodulin-dependent kinases inhibit inhibitor A 3 hydrochloride cAMP calmodulin A3 Hydrochloride kinase A-3 MLC-kinase Calmodulin-dependent protein kinases Protein kinase C Protein kinase A A 3 Hydrochloride A 3 A-3 Hydrochloride casein A3 hydrochloride