Powder: -20°C for 3 years | In solvent: -80°C for 1 year
7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 38.00 | |
10 mg | In stock | $ 61.00 | |
25 mg | In stock | $ 128.00 | |
50 mg | In stock | $ 245.00 | |
100 mg | In stock | $ 473.00 | |
500 mg | In stock | $ 987.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 67.00 |
Description | 7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery. |
Targets&IC50 | Glycine B coagonist site of NMDA receptor:0.56 μM(ki), Reuptake of glutamate:(ki)0.59 μM |
In vivo | In male Sprague-Dawley rats, 7-Chlorokynurenic acid (10 nM) retardates the development of both the electroencephalographic and motor (17.7 daily stimulations) components of the seizure response[3]. |
Synonyms | 7-chloro-4-hydroxy-2-carboxyquinoline, 7-CKA |
Molecular Weight | 223.61 |
Formula | C10H6ClNO3 |
CAS No. | 18000-24-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 15 mg/mL (67.1 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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7-Chlorokynurenic acid 18000-24-3 Neuroscience NMDAR GluR 7-chloro-4-hydroxy-2-carboxyquinoline 7-CKA inhibitor inhibit