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U-104

Catalog No. T2017 CAS 178606-66-1

Synonyms: NSC-213841, MST-104

U-104 (NSC-213841) is an effective carbonic anhydrase (CA) inhibitor for CA IX( Ki=45.1 nM) and CA XII(Ki=4.5 nM).

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U-104, CAS 178606-66-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 30.00
10 mg	In stock	$ 48.00
25 mg	In stock	$ 89.00
50 mg	In stock	$ 145.00
100 mg	In stock	$ 263.00
200 mg	In stock	$ 421.00
500 mg	In stock	$ 686.00
1 mL * 10 mM (in DMSO)	In stock	$ 53.00

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Purity: 100%

Purity: 99.6%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	U-104 (NSC-213841) is an effective carbonic anhydrase (CA) inhibitor for CA IX( Ki=45.1 nM) and CA XII(Ki=4.5 nM).
Targets&IC50	CA XII:4.5 nM(Ki), CA IX:45.1 nM(Ki)
Kinase Assay	Kinase assay: Calu-6 cells are cultured in MEM containing 10% fetal bovine serum and 1% penicillin/streptomycin and plated 1 day before the start of the experiment at 1 × 104 cells per well in a 384-well plate. Proteasome activity is assessed by monitoring hydrolysis of the chymotrypsin-like substrate Suc-LLVY-aminoluciferin in the presence of luciferase using the Proteasome-Glo assay reagents according to the manufacturer's instructions. Luminescence is measured using a LEADseeker instrument.

Synonyms	NSC-213841, MST-104
Molecular Weight	309.32
Formula	C13H12FN3O3S
CAS No.	178606-66-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30.9 mg/mL (100 mM)

References and Literature

1. Lou Y, et al. Cancer Res, 2011, 71(9), 3364-3376. 2. Lock FE, et al. Oncogene, 2012, doi: 10.1038, onc.2012. 550. 3. Pacchiano F, et al. J Med Chem, 2011, 54(6), 1896-1902.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Inhibitor Library Anti-Metabolism Disease Compound Library NO PAINS Compound Library Anti-Cancer Compound Library Anti-Cancer Metabolism Compound Library Metabolism Compound Library

Related Products

Related compounds with same targets

Carbonic anhydrase inhibitor 12 Disulfamide WES-1 ALP/Carbonic anhydrase-IN-1 pNNP 2,3-dihydro-1H-indene-5-sulfonamide hCAXII-IN-7 Methyl 2,4-dihydroxybenzoate

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

U-104 178606-66-1 Metabolism Carbonic Anhydrase LM2-4 NSC213841 CAIX CAI CAXII exosome SLC-0111 SLC0111 Carbonate dehydratase NSC 213841 U104 inhibit SLC 0111 NSC-213841 MST-104 4T1 U 104 Inhibitor CAII MST104 MST 104 inhibitor

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