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Phlorizin

Catalog No. T2922 CAS 60-81-1

Synonyms: Floridzin, NSC 2833, Phloridzin

Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .

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Phlorizin, CAS 60-81-1

Pack Size	Availability	Price/USD
500 mg	In stock	$ 46.00
1 g	In stock	$ 55.00
5 g	In stock	$ 197.00
1 mL * 10 mM (in DMSO)	In stock	$ 51.00

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Purity: 99.76%

Purity: 99.68%

Purity: 99.58%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .
Targets&IC50	SGLT1 (human):300 nM(Ki), SGLT2 (human):39 nM(Ki)
In vivo	In the treatment of diabetes, obesity, and stress-induced hyperglycemia, Phlorizin exerts its therapeutic effects by inhibiting the sodium-glucose cotransporters located in the proximal renal tubules and the intestinal mucosa. This inhibition results in renal glucosuria and impedes the absorption of glucose in the intestines.
Source	Natural Products > Rosaceae > Prunus

Synonyms	Floridzin, NSC 2833, Phloridzin
Molecular Weight	436.41
Formula	C21H24O10
CAS No.	60-81-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 43.6 mg/mL (100 mM)

DMSO: 43.6 mg/mL (100 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Taton J, et al. Endokrynol Pol, 2010, 61(3), 303-310. 2. Ehrenkranz JR, et al. Diabetes Metab Res Rev, 2005, 21(1), 31-38. 3. Shim K S, Hwang Y H, Jang S A, et al. . Water Extract of Lysimachia christinae Inhibits Trabecular Bone Loss and Fat Accumulation in Ovariectomized Mice[J]. Nutrients. 2020, 12(7): 1927. 4. Chen Q, Sun D, Fang T, et al. In vitro allelopathic effects of compounds from Cerbera manghas L. on three Dinophyta species responsible for harmful common red tides. Science of The Total Environment. 2020: 142253.

Citations

1. Shim K S, Hwang Y H, Jang S A, et al. Water Extract of Lysimachia christinae Inhibits Trabecular Bone Loss and Fat Accumulation in Ovariectomized Mice. Nutrients. 2020, 12(7): 1927 2. Tsang C C, Tang J Y M, Ye H, et al. Rare/cryptic Aspergillus species infections and importance of antifungal susceptibility testing. Mycoses. 2020, 63(12): 1283-1298

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Miao medicine Compound Library GPCR Compound Library Membrane Protein-targeted Compound Library Chinese Pharmacopoeia Natural Product Library Anti-Obesity Compound Library Selected Plant-Sourced Compound Library Glutamine Metabolism Compound Library Anti-Metabolism Disease Compound Library Bioactive Compounds Library Max

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Phlorizin 60-81-1 GPCR/G Protein Membrane transporter/Ion channel SGLT ATPase Floridzin Na+/K+ ATPase Sodium potassium pump Inhibitor NSC-2833 inhibit NSC2833 NSC 2833 Sodium-dependent glucose cotransporters Phloridzin inhibitor

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