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m-Chlorophenylbiguanide hydrochloride

Catalog No. T22959 CAS 2113-05-5

Synonyms: 1-(3-Chlorophenyl)biguanidehydrochloride

m-Chlorophenylbiguanide hydrochloride is a 5-HT3 receptor agonist. m-Chlorophenylbiguanide hydrochloride selectively binds 5-HT3(Ki: 0.002 µM) over 5-HT1A(Ki: 10 µM) and 5-HT2(Ki: 10 µM) receptors but also binds to high and low affinity sites on the dopamine transporter(DAT; IC50s: 0.4 and 34.8 µM, respectively, in rat caudate putamen synaptosomal membranes).

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m-Chlorophenylbiguanide hydrochloride Chemical Structure

m-Chlorophenylbiguanide hydrochloride, CAS 2113-05-5

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100 mg	In stock	$ 42.00

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Purity: 99.87%

Purity: 99.43%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	m-Chlorophenylbiguanide hydrochloride is a 5-HT3 receptor agonist. m-Chlorophenylbiguanide hydrochloride selectively binds 5-HT3(Ki: 0.002 µM) over 5-HT1A(Ki: 10 µM) and 5-HT2(Ki: 10 µM) receptors but also binds to high and low affinity sites on the dopamine transporter(DAT; IC50s: 0.4 and 34.8 µM, respectively, in rat caudate putamen synaptosomal membranes).
Targets&IC50	5-HT1:10 µM(Ki), 5-HT2:10 µM(Ki), 5-HT3:0.002 µM(Ki)
In vivo	m-Chlorophenylbiguanide hydrochloride induces depolarization of isolated rat vagus nerve and stimulates inositol phosphate formation in rat frontocingulate cortical slices (EC50s = 0.05 and 4.2 μM, respectively).m-Chlorophenylbiguanide hydrochloride induces bradycardia, an effect that can be reversed by the 5-HT3 receptor antagonist ondansetron, in anaesthetized cats (ED50 = 20.3 nmol/kg)[1].

Synonyms	1-(3-Chlorophenyl)biguanidehydrochloride
Molecular Weight	248.11
Formula	C8H11Cl2N5
CAS No.	2113-05-5

Storage

store under nitrogen

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (241.83 mM)

H2O: < 20 mg/mL (80.61 mM)

References and Literature

1. Kilpatrick GJ, et al. 1-(m-chlorophenyl)-biguanide, a potent high affinity 5-HT3 receptor agonist. Eur J Pharmacol. 1990 Jun 21;182(1):193-7. 2. Campbell AD, Womer DE, Simon JR. The 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide interacts with the dopamine transporter in rat brain synaptosomes. Eur J Pharmacol. 1995 Jul 18;290(2):157-62. 3. Higgins GA, Joharchi N, Sellers EM. Behavioral effects of the 5-hydroxytryptamine3 receptor agonists 1-phenylbiguanide and m-chlorophenylbiguanide in rats. J Pharmacol Exp Ther. 1993 Mar;264(3):1440-9. 4. Edwards E, et al. 5-HT3-like receptors in the rat medial prefrontal cortex: further pharmacological characterization. Brain Res. 1996 Sep 9;733(1):21-30.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library GPCR Compound Library Membrane Protein-targeted Compound Library Anti-Cancer Compound Library Neuronal Signaling Compound Library Bioactive Compound Library Neurotransmitter Receptor Compound Library Bioactive Compounds Library Max Serotonin Receptor-Targeted Compound Library Anti-Parkinson's Disease Compound Library

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Keywords

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