Powder: -20°C for 3 years | In solvent: -80°C for 1 year
G-1 is a nonsteroidal, high-affinity and selective GPR30 agonist (Ki: 11 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 43.00 | |
5 mg | In stock | $ 80.00 | |
10 mg | In stock | $ 126.00 | |
25 mg | In stock | $ 223.00 | |
50 mg | In stock | $ 369.00 | |
100 mg | In stock | $ 531.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 75.00 |
Description | G-1 is a nonsteroidal, high-affinity and selective GPR30 agonist (Ki: 11 nM). |
Targets&IC50 | GPR30:(ki)11 nM |
In vitro | Treatment with G-1 (10 μM and 100 μM; 48 and 72 h) obviously reduces cell proliferation (P<0.001). At 72 h, the IC50 value for G-1 is calculated to be 20 μM. Cell cycle analysis of H295R cells after 24 h of G-1 treatment shows a cell cycle arrest in the G2 phase. Treatment of A549 cells with G-1(20 μM) reveals a significant increase in apoptosis, consistent with its antiproliferative effect (P<0.001)[2]. The presence of G-1 increases Bax expression while reduces Bcl-2[3]. |
In vivo | After 14 days post-injury, the results display that the Basso mouse scale scores are obviously higher in the G-1 group compared with the other groups (P<0.05). G-1 administration produces a statistically significant induce in tumor volume from day 14 post-treatment. Grafted tumors harvested after a three-week treatment with G-1 show a significant decrease in tumor weight compare to vehicle-treated animals[3]. The number of caspase-3-positive cells in the cross-sections is counted, and G-1 group has fewer positive cells compared with the other groups (P<0.05), and there is no difference between the two groups (P>0.05)[1]. |
Molecular Weight | 412.28 |
Formula | C21H18BrNO3 |
CAS No. | 881639-98-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 0.1 mg/mL (insoluble)
DMSO: 50 mg/mL (121.28 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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G-1 881639-98-1 Endocrinology/Hormones GPCR/G Protein Estrogen Receptor/ERR GPR Inhibitor inhibit G1 G 1 inhibitor