Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Kuwanon H is a specific antagonist for the gastrin-releasing peptide (GRP) -preferring receptor with Ki values of 290 nM and can be useful for studying the physiological and pathological role of GRP. Kuwanon H is a potent non-peptide bombesin receptor antagonist.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 155.00 | |
5 mg | In stock | $ 389.00 | |
10 mg | In stock | $ 573.00 | |
25 mg | In stock | $ 883.00 | |
50 mg | In stock | $ 1,190.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 549.00 |
Description | Kuwanon H is a specific antagonist for the gastrin-releasing peptide (GRP) -preferring receptor with Ki values of 290 nM and can be useful for studying the physiological and pathological role of GRP. Kuwanon H is a potent non-peptide bombesin receptor antagonist. |
Targets&IC50 | GRP:290 nM(Ki) |
In vitro | Kuwanon G and H, isolated from the methanol extract of Morus bombycis, inhibited specific binding of [125I]gastrin-releasing peptide (GRP) to GRP-preferring receptors in murine Swiss 3T3 fibroblasts with Ki values of 470 and 290 nM, respectively. Kuwanon H was one order of magnitude less potent for inhibiting [125I]bombesin binding to neuromedin B (NMB)-preferring receptors in rat esophagus membranes. This compound antagonized bombesin-induced increases in the cytosolic free calcium concentration and GRP-induced DNA synthesis in Swiss 3T3 cells. |
Source |
Molecular Weight | 760.82 |
Formula | C45H44O11 |
CAS No. | 76472-87-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (65.72 mM)
You can also refer to dose conversion for different animals. More
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Kuwanon H 76472-87-2 Endocrinology/Hormones GPCR/G Protein GPR Bombesin Receptor Inhibitor inhibit inhibitor