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6-Diazo-5-oxo-L-nor-Leucine

Catalog No. T8373 CAS 157-03-9

Synonyms: L-6-Diazo-5-oxonorleucine, DON, 6-重氮-5-氧代-L-正亮氨酸, Diazooxonorleucine

L-6-Diazo-5-oxonorleucine is an antagonist of glutaminases (Ki : 6 μM). It is an antineoplastic antibiotic produced by an unidentified species of Streptomyces from Peruvian soil.

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6-Diazo-5-oxo-L-nor-Leucine, CAS 157-03-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	L-6-Diazo-5-oxonorleucine is an antagonist of glutaminases (Ki : 6 μM). It is an antineoplastic antibiotic produced by an unidentified species of Streptomyces from Peruvian soil.
Targets&IC50	glutaminases:6 μM(Ki)

Synonyms	L-6-Diazo-5-oxonorleucine, DON, 6-重氮-5-氧代-L-正亮氨酸, Diazooxonorleucine
Molecular Weight	171.156
Formula	C6H9N3O3
CAS No.	157-03-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Willis RC, et al. The inhibition by 6-diazo-5-oxo-l-norleucine of glutamine catabolism of the cultured human lymphoblast. J Cell Physiol. 1977 Dec;93(3):375-82. 2. Kulkarni RM, et al. Evaluation of genetic toxicity of 6-diazo-5-oxo-l-norleucine (DON). Toxicol Mech Methods. 2017 Sep;27(7):518-527. 3. Turley E A . The Control of Adrenocortical Cytodifferentiation by Extracellular Matrix***[J]. differentiation, 1980, 17(1-3):93-103.

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Keywords

6-Diazo-5-oxo-L-nor-Leucine 157-03-9 蛋白酶体微生物学 Antibacterial Antibiotic Glutaminase Influenza Virus Bacterial Inhibitor inhibit L-6-Diazo-5-oxonorleucine DON Diazooxonorleucine 6Diazo5oxoLnorLeucine 6 Diazo 5 oxo L nor Leucine inhibitor

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