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KI-7

Catalog No. T9238 CAS 1489263-00-4

KI-7 is an adenosine A2B receptor positive allosteric modulator.

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KI-7, CAS 1489263-00-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 38.00
5 mg	In stock	$ 89.00
10 mg	In stock	$ 153.00
25 mg	In stock	$ 318.00
50 mg	In stock	$ 490.00
100 mg	In stock	$ 738.00
500 mg	In stock	$ 1,530.00
1 mL * 10 mM (in DMSO)	In stock	$ 98.00

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Purity: 98.03%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	KI-7 is an adenosine A2B receptor positive allosteric modulator.
In vitro	KI-7 potentiates the cAMP accumulation induced by the non-selective A2B adenosine receptor agonist NECA (EC50=445.8 nM). KI-7 also potentiates the cAMP accumulation induced by the selective A2B adenosine receptor agonist BAY 60-6583 as well as by adenosine with EC50s of 2390 nM and 2550 nM, respectively[1][2].

Molecular Weight	354.4
Formula	C23H18N2O2
CAS No.	1489263-00-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 240 mg/mL (677.20 mM), Sonication is recommended.

References and Literature

1. Trincavelli ML, et al. Allosteric modulators of human A2B adenosine receptor. Biochim Biophys Acta. 2014;1840(3):1194-1203. 2. Trincavelli ML, et al. Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators. Biochim Biophys Acta. 2014;1843(12):2957-2966.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library GPCR Compound Library Neuronal Signaling Compound Library Bioactive Compounds Library Max Bioactive Compound Library

Related Products

Related compounds with same targets

Xanthine amine congener 1-Ethyl-6-aminouracil Alloxazine LAS38096 Aminophylline A2A receptor antagonist 1 Kira8 Hydrochloride CGS 15943

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

KI-7 1489263-00-4 GPCR/G Protein Neuroscience Adenosine Receptor potentiate Runx2 Osterix KI 7 Inhibitor P1 receptor inhibit orthosteric MSC cAMP accumulation allosteric KI7 inhibitor

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