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Laropiprant

Name: Laropiprant
Brand: TargetMol
SKU: T15712
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15712Cas No. 571170-77-9

Alias MK-0524

Laropiprant (MK-0524) is a potent and selective antagonist of prostaglandin D2 (PGD2) receptor (DP) such as and DP/DP1 receptor(Ki = 0.57 nM) and TP Receptor(Ki = 2.95 nM).

Laropiprant

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Purity: 99.89%

Catalog No. T15712Alias MK-0524Cas No. 571170-77-9

Laropiprant (MK-0524) is a potent and selective antagonist of prostaglandin D2 (PGD2) receptor (DP) such as and DP/DP1 receptor(Ki = 0.57 nM) and TP Receptor(Ki = 2.95 nM).

Pack Size	Price	Availability
1 mg	$32	In Stock
5 mg	$79	In Stock
10 mg	$115	In Stock
25 mg	$231	In Stock
50 mg	$355	In Stock
100 mg	$507	In Stock
200 mg	$693	In Stock
1 mL x 10 mM (in DMSO)	$87	In Stock

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Purity:99.89%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Laropiprant (MK-0524) is a potent and selective antagonist of prostaglandin D2 (PGD2) receptor (DP) such as and DP/DP1 receptor(Ki = 0.57 nM) and TP Receptor(Ki = 2.95 nM).
Targets&IC50	DP/DP1 receptor:0.57 nM (ki), TP receptor:2.95 nM (ki)
In vitro	Laropiprant blocks DP receptor-dependent enhance in VASP phosphorylation, as well as inhibition of P-selectin expression, GPIIb/IIIa activation, and in vitro thrombus formation. Laropiprant antagonizes the increased platelet aggregation by TP and EP3 receptor activation. Laropiprant (1 μM) induces a significant inhibition of the aggregation but still counteracts the pronounced inhibition caused by PGD2 (30 nM) and BW245c (3 nM). Laropiprant (10 μM) and niacin inhibit in vitro thrombus formation[2].
Synonyms	MK-0524

Chemical Properties

Molecular Weight	435.9
Formula	C₂₁H₁₉ClFNO₄S
Cas No.	571170-77-9
Smiles	CS(=O)(=O)c1cc(F)cc2c3CC[C@H](CC(O)=O)c3n(Cc3ccc(Cl)cc3)c12
Relative Density.	1.486 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (229.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2941 mL	11.4705 mL	22.9410 mL	114.7052 mL
5 mM	0.4588 mL	2.2941 mL	4.5882 mL	22.9410 mL
10 mM	0.2294 mL	1.1471 mL	2.2941 mL	11.4705 mL
20 mM	0.1147 mL	0.5735 mL	1.1471 mL	5.7353 mL
50 mM	0.0459 mL	0.2294 mL	0.4588 mL	2.2941 mL
100 mM	0.0229 mL	0.1147 mL	0.2294 mL	1.1471 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc