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alpha-Mangostin

Catalog No. T1717 CAS 6147-11-1

Synonyms: α-Mangostin, Mangostin

alpha-Mangostin (Mangostin) is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.

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alpha-Mangostin, CAS 6147-11-1

Pack Size	Availability	Price/USD
10 mg	In stock	$ 41.00
25 mg	In stock	$ 91.00
50 mg	In stock	$ 166.00
100 mg	In stock	$ 316.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 98.12%

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Description	alpha-Mangostin (Mangostin) is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.
Targets&IC50	IDH1 (mutant, R132H):2.85 μM(ki)
In vitro	Alpha-mangostin exhibits a selective inhibitory effect on IDH1-R132H, but not on IDH1. Alpha-mangostin competitively inhibits the binding of alpha-mangostin (α-KG) to IDH1-R132H. The structure–relationship study reveals that alpha-mangostin exhibits the strongest core inhibitor structure. Alpha-mangostin selectively promotes demethylation of 5-methylcytosine (5mC) and histone H3 trimethylated lysine residues in IDH1 (+/R132H) MCF10A cells[1]. Cell proliferation significantly decreases in a dose-dependent manner in the cells treated with alpha-mangostin. Alpha-mangostin also increases the levels of Bax (pro-apoptotic), cleaved caspase-3, cleaved caspase-9 and cleaved-poly(ADP-ribose) polymerase (PARP)[2]. Alpha-mangostin significantly inhibits light-induced degeneration of photoreceptors and 200 μM Water2-induced apoptosis of RPE cells. 200 μM Water2-induced generation of reactive oxygen species (ROS) and light-induced generation of malondialdehyde (MDA) are suppressed by alpha-mangostin[3].
In vivo	Alpha-mangostin mitigates the risk of liver fibrosis by diminishing p53 expression relative to TAA_DMSO treatment. Moreover, following α-mangostin administration, serum concentrations of liver enzymes AST and ALT are reduced in comparison to treatment with DMSO alone[4].
Cell Research	IDH1+/+ and IDH1<sup+/R132H MCF10A cells are grown in DMEM/F-12 media, supplemented with 5% horse serum, 20 ng/mL EGF, 0.5 μg/mL hydrocortisone, 10 μg/mL insulin. IDH1+/+ and IDH1<sup+/R132H MCF10A cells are seeded in 6 well plates. After an exposure to 5 μM alpha-mangostin. cells are collected after indicated times and the viable cell number is calculated, using hemacytometer counting[1].
Source	Natural Products > Clusiaceae > Garcinia

Synonyms	α-Mangostin, Mangostin
Molecular Weight	410.46
Formula	C24H26O6
CAS No.	6147-11-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (109.63 mM)

References and Literature

1. LEE, H., JANG, H., KIM, H., SHIN, S., CHOO, G., & PARK, Y. et al. (2016). Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.) in YD-15 tongue mucoepidermoid carcinoma cells. International Journal Of Molecular Medicine, 37(4), 939-948. doi: 10.3892/ijmm.2016.2517

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Antiparasitic Natural Product Library Tobacco Monomer Library Anti-Cancer Metabolism Compound Library ReFRAME Related Library Anti-Fungal Compound Library Anti-Obesity Compound Library Mitochondria-Targeted Compound Library Immunology/Inflammation Compound Library Anti-Infection Compound Library

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Keywords

alpha-Mangostin 6147-11-1 Apoptosis Immunology/Inflammation Metabolism Microbiology/Virology NF-Κb Antifungal Antibacterial Reactive Oxygen Species Virus Protease Dehydrogenase Fungal inhibit Inhibitor alpha Mangostin α-Mangostin alphaMangostin Bacterial Mangostin a-Mangostin inhibitor

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