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Corylifol A

Catalog No. T4S0145   CAS 775351-88-7
Synonyms: Corylinin, 补骨脂异黄酮A

1. Corylifol A displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. 2. Corylifol A and Biochanin A can be the potential uncouplers of neuronal nitric oxide synthase-postsynaptic density protein-95. 3. Corylifol A and bavachin are strong inhibitors of UDP-glucuronosyltransferase 1A1 (UGT1A1) with the inhibition kinetic parameters (Ki) values lower than 1 uM.4. Corylifol A and bakuchiol are naturally occurring potent inhibitors of hCE2, with low Ki values ranging from 0.62uM to 3.89 uM. 5. Corylifol A shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 values of 0.81 ± 0.15 uμ, it also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells, suggests that corylifol A has antiinflammatory activity.

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Corylifol A, CAS 775351-88-7
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 1. Corylifol A displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. 2. Corylifol A and Biochanin A can be the potential uncouplers of neuronal nitric oxide synthase-postsynaptic density protein-95. 3. Corylifol A and bavachin are strong inhibitors of UDP-glucuronosyltransferase 1A1 (UGT1A1) with the inhibition kinetic parameters (Ki) values lower than 1 uM.4. Corylifol A and bakuchiol are naturally occurring potent inhibitors of hCE2, with low Ki values ranging from 0.62uM to 3.89 uM. 5. Corylifol A shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 values of 0.81 ± 0.15 uμ, it also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells, suggests that corylifol A has antiinflammatory activity.
Targets&IC50 STAT3:0.81 μM
Synonyms Corylinin, 补骨脂异黄酮A
Molecular Weight 390.47
Formula C25H26O4
CAS No. 775351-88-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 15.4 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Li, N., Miao, J., Li, J., Zhao, Y., Li, H., & Dai, Y. et al. (2017). Enzymatic synthesis of novel corylifol A glucosides via a UDP-glycosyltransferase. Carbohydrate Research, 446-447, 61-67. doi: 10.1016/j.carres.2017.05.002

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Flavonoid Natural Product Library Traditional Chinese Medicine Monomer Library Anti-Pancreatic Cancer Compound Library Inhibitor Library Polyphenolic Natural Product Library Natural Product Library for HTS Anti-Tumor Natural Product Library Immuno-Oncology Compound Library Immunology/Inflammation Compound Library

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Alisol G Corylifol A

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Keywords

Corylifol A 775351-88-7 JAK/STAT信号通路 代谢 干细胞 hCE STAT UGT Inhibitor inhibit Corylinin Corylifol-A inhibitor