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Corylifol A

Catalog No. T4S0145   CAS 775351-88-7
Synonyms: Corylinin

1. Corylifol A (Corylinin) displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. 2. Corylifol A and Biochanin A can be the potential uncouplers of neuronal nitric oxide synthase-postsynaptic density protein-95. 3. Corylifol A and bavachin are strong inhibitors of UDP-glucuronosyltransferase 1A1 (UGT1A1) with the inhibition kinetic parameters (Ki) values lower than 1 uM.4. Corylifol A and bakuchiol are naturally occurring potent inhibitors of hCE2, with low Ki values ranging from 0.62uM to 3.89 uM. 5. Corylifol A shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 values of 0.81 ± 0.15 uμ, it also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells, suggests that corylifol A has antiinflammatory activity.

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Corylifol A Chemical Structure
Corylifol A, CAS 775351-88-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 47.00
5 mg In stock $ 97.00
10 mg In stock $ 155.00
25 mg In stock $ 262.00
50 mg In stock $ 389.00
100 mg In stock $ 573.00
500 mg In stock $ 1,190.00
1 mL * 10 mM (in DMSO) In stock $ 148.00
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Purity: 99.48%
Purity: 97.19%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 1. Corylifol A (Corylinin) displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. 2. Corylifol A and Biochanin A can be the potential uncouplers of neuronal nitric oxide synthase-postsynaptic density protein-95. 3. Corylifol A and bavachin are strong inhibitors of UDP-glucuronosyltransferase 1A1 (UGT1A1) with the inhibition kinetic parameters (Ki) values lower than 1 uM.4. Corylifol A and bakuchiol are naturally occurring potent inhibitors of hCE2, with low Ki values ranging from 0.62uM to 3.89 uM. 5. Corylifol A shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 values of 0.81 ± 0.15 uμ, it also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells, suggests that corylifol A has antiinflammatory activity.
Targets&IC50 STAT3:0.81 μM
Source
Synonyms Corylinin
Molecular Weight 390.47
Formula C25H26O4
CAS No. 775351-88-7

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (128.05 mM)

TargetMolReferences and Literature

1. Li, N., Miao, J., Li, J., Zhao, Y., Li, H., & Dai, Y. et al. (2017). Enzymatic synthesis of novel corylifol A glucosides via a UDP-glycosyltransferase. Carbohydrate Research, 446-447, 61-67. doi: 10.1016/j.carres.2017.05.002

TargetMolCitations

1. Chen J, Zhou X, Fu L, et al.Natural Product-Based Screening for Lead Compounds Targeting SARS CoV-2 Mpro[J]. Pharmaceuticals, 2023, 16(5): 767..Pharmaceuticals.2023, 16(5): 767.

Related compound libraries

This product is contained In the following compound libraries:
Natural Product Library Flavonoid Natural Product Library Inhibitor Library Natural Product Library for HTS Traditional Chinese Medicine Monomer Library Anti-Colorectal Cancer Compound Library Anti-Liver Cancer Compound Library Chinese Pharmacopoeia Natural Product Library JAK-STAT Compound Library Selected Plant-Sourced Compound Library

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Keywords

Corylifol A 775351-88-7 JAK/STAT signaling Metabolism Stem Cells STAT UGT hCE Inhibitor Corylinin inhibit Corylifol-A inhibitor

 

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