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Kukoamine A

Name: Kukoamine A
Brand: TargetMol
SKU: TN1016
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1016Cas No. 75288-96-9

Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, and inhibits trypanothione reductase as a mixed inhibitor (Ki = 1.8 microM).

Kukoamine A

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Purity: 99.35%

Catalog No. TN1016Cas No. 75288-96-9

Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, and inhibits trypanothione reductase as a mixed inhibitor (Ki = 1.8 microM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
2 mg	$76	In Stock	In Stock
5 mg	$143	In Stock	In Stock
10 mg	$259	In Stock	In Stock
25 mg	$439	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$167	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.35%

Appearance:Solid

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, and inhibits trypanothione reductase as a mixed inhibitor (Ki = 1.8 microM).
Targets&IC50	Trypanothione reductase:1.8 microM(Ki), LOX:9.5 microM
In vitro	The four possible regioisomers of Kukoamine A, as well as a series of Kukoamine A analogs incorporating changes in either the SPM or the DHCA structural units, were evaluated for their antioxidant activity and their inhibitory activity on soybean lipoxygenase (LOX) and lipid peroxidation[1]. The reducing properties of the compounds were evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay and found to be in the range 5-97.5%. Kukoamine A significantly inhibits LOX with IC50 9.5 microM. All tested analogs inhibited lipid peroxidation in the range of 11-100%[1].
In vivo	Kukoamine A has neuroprotective effects through inhibiting oxidative stress and apoptosis after whole-brain irradiation (WBI) in rats[1].

Chemical Properties

Molecular Weight	530.66
Formula	C₂₈H₄₂N₄O₆
Cas No.	75288-96-9
Smiles	Oc1ccc(CCC(=O)NCCCNCCCCNCCCNC(=O)CCc2ccc(O)c(O)c2)cc1O
Relative Density.	1.213 g/cm3 at 20℃

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (113.07 mM), Sonication is recommended.

H2O: 100 mg/mL (188.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.77 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.8844 mL	9.4222 mL	18.8445 mL	94.2223 mL
5 mM	0.3769 mL	1.8844 mL	3.7689 mL	18.8445 mL
10 mM	0.1884 mL	0.9422 mL	1.8844 mL	9.4222 mL
20 mM	0.0942 mL	0.4711 mL	0.9422 mL	4.7111 mL
50 mM	0.0377 mL	0.1884 mL	0.3769 mL	1.8844 mL
100 mM	0.0188 mL	0.0942 mL	0.1884 mL	0.9422 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc