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Kukoamine A

Kukoamine A
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Purity:97.45%
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Kukoamine A

Catalog No. TN1016Cas No. 75288-96-9
Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, and inhibits trypanothione reductase as a mixed inhibitor (Ki = 1.8 microM).
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Pack SizePriceAvailabilityQuantity
1 mg$94In Stock
5 mg$286In Stock
10 mg$489In Stock
25 mg$845In Stock
50 mgInquiryIn Stock
1 mL x 10 mM (in DMSO)$328In Stock
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Product Introduction

Bioactivity
Description
Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidative stress and apoptosis after whole-brain irradiation (WBI) in rats.
In vitro
The four possible regioisomers of Kukoamine A, as well as a series of Kukoamine A analogs incorporating changes in either the SPM or the DHCA structural units, were evaluated for their antioxidant activity and their inhibitory activity on soybean lipoxygenase (LOX) and lipid peroxidation[1]. The reducing properties of the compounds were evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay and found to be in the range 5-97.5%. Kukoamine A significantly inhibits LOX with IC50 9.5 microM. All tested analogs inhibited lipid peroxidation in the range of 11-100%[1].
In vivo
Kukoamine A has neuroprotective effects through inhibiting oxidative stress and apoptosis after whole-brain irradiation (WBI) in rats[1].
Chemical Properties
Molecular Weight530.66
FormulaC28H42N4O6
Cas No.75288-96-9
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 60 mg/mL (113.07 mM)
H2O: 100 mg/mL (188.44 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.8844 mL9.4222 mL18.8445 mL94.2223 mL
5 mM0.3769 mL1.8844 mL3.7689 mL18.8445 mL
10 mM0.1884 mL0.9422 mL1.8844 mL9.4222 mL
20 mM0.0942 mL0.4711 mL0.9422 mL4.7111 mL
50 mM0.0377 mL0.1884 mL0.3769 mL1.8844 mL
100 mM0.0188 mL0.0942 mL0.1884 mL0.9422 mL

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