Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, and inhibits trypanothione reductase as a mixed inhibitor (Ki = 1.8 microM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 123.00 | |
5 mg | In stock | $ 375.00 | |
10 mg | In stock | $ 557.00 | |
25 mg | In stock | $ 882.00 | |
50 mg | In stock | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | $ 413.00 |
Description | Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, and inhibits trypanothione reductase as a mixed inhibitor (Ki = 1.8 microM). |
Targets&IC50 | LOX:9.5 microM, Trypanothione reductase:1.8 microM(Ki) |
In vitro | The four possible regioisomers of Kukoamine A, as well as a series of Kukoamine A analogs incorporating changes in either the SPM or the DHCA structural units, were evaluated for their antioxidant activity and their inhibitory activity on soybean lipoxygenase (LOX) and lipid peroxidation[1]. The reducing properties of the compounds were evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay and found to be in the range 5-97.5%. Kukoamine A significantly inhibits LOX with IC50 9.5 microM. All tested analogs inhibited lipid peroxidation in the range of 11-100%[1]. |
In vivo | Kukoamine A has neuroprotective effects through inhibiting oxidative stress and apoptosis after whole-brain irradiation (WBI) in rats[1]. |
Source |
Molecular Weight | 530.66 |
Formula | C28H42N4O6 |
CAS No. | 75288-96-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (113.07 mM)
H2O: 100 mg/mL (188.44 mM)
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Kukoamine A 75288-96-9 Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism Microbiology/Virology NF-Κb DNA/RNA Synthesis NF-κB Lipoxygenase Parasite inhibit Inhibitor inhibitor