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Microbiology/Virology Parasite Kukoamine A

Kukoamine A

Catalog No. TN1016   CAS 75288-96-9

Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, and inhibits trypanothione reductase as a mixed inhibitor (Ki = 1.8 microM).

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Kukoamine A, CAS 75288-96-9
Pack Size Availability Price/USD Quantity
1 mg In stock 142.00
5 mg In stock 417.00
10 mg In stock 627.00
25 mg In stock 1127.00
50 mg In stock 1689.00
100 mg In stock 2534.00
1 mL * 10 mM (in DMSO) In stock 715.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, and inhibits trypanothione reductase as a mixed inhibitor (Ki = 1.8 microM).
Targets&IC50 NF-κB ,   AP-1 ,   LOX
In vitro The four possible regioisomers of Kukoamine A, as well as a series of Kukoamine A analogs incorporating changes in either the SPM or the DHCA structural units, were evaluated for their antioxidant activity and their inhibitory activity on soybean lipoxygenase (LOX) and lipid peroxidation[1]. The reducing properties of the compounds were evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay and found to be in the range 5-97.5%. Kukoamine A significantly inhibits LOX with IC50 9.5 microM. All tested analogs inhibited lipid peroxidation in the range of 11-100%[1].
In vivo Kukoamine A has neuroprotective effects through inhibiting oxidative stress and apoptosis after whole-brain irradiation (WBI) in rats[1].
Molecular Weight 530.66
Formula C28H42N4O6
CAS No. 75288-96-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

H2O: 100 mg/mL (188.44 mM)

DMSO: 60 mg/mL (113.07 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Hadjipavlou-Litina D, et al. Kukoamine A analogs with lipoxygenase inhibitory activity. J Enzyme Inhib Med Chem. 2009 Oct;24(5):1188-93.

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