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Hibifolin

Hibifolin
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Purity:98.13%
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Hibifolin

Catalog No. TN1736Cas No. 55366-56-8
Hibifolin is a flavonol glycoside natural product,is a potential inhibitor of adenosine deaminase (Ki of 49.92 μM). Hibifolin protects neurons against beta-amyloid-induced neurotoxicity.
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Pack SizePriceAvailabilityQuantity
1 mg$54In Stock
5 mg$122In Stock
10 mg$178In Stock
25 mg$297In Stock
50 mg$453In Stock
100 mg$655In Stock
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Product Introduction

Bioactivity
Description
Hibifolin is a flavonol glycoside natural product,is a potential inhibitor of adenosine deaminase (Ki of 49.92 μM). Hibifolin protects neurons against beta-amyloid-induced neurotoxicity.
In vitro
the inhibitory activity of a plant flavonoid, hibifolin on ADA is investigated using enzyme kinetic assay and isothermal titration calorimetry.?The inhibitory constant of hibifolin was found to be 49.92μM 3.98 and the mode of binding was reversible.?Isothermal titration calorimetry showed that the compound binds ADA with binding energy of -7.21Kcal/mol.?The in silico modeling and docking studies showed that the bound ligand is stabilized by hydrogen bonds with active site residues of the enzyme.?hibifolin can act as a potential inhibitor of ADA.
Chemical Properties
Molecular Weight494.36
FormulaC21H18O14
Cas No.55366-56-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 55 mg/mL (111.25 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0228 mL10.1141 mL20.2282 mL101.1409 mL
5 mM0.4046 mL2.0228 mL4.0456 mL20.2282 mL
10 mM0.2023 mL1.0114 mL2.0228 mL10.1141 mL
20 mM0.1011 mL0.5057 mL1.0114 mL5.0570 mL
50 mM0.0405 mL0.2023 mL0.4046 mL2.0228 mL
100 mM0.0202 mL0.1011 mL0.2023 mL1.0114 mL

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