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Hibifolin

Catalog No. TN1736 CAS 55366-56-8

Synonyms: 棉皮素-8-O-Β-D-葡萄糖醛酸苷, 棉花皮素-8-O-葡萄糖醛酸苷

Hibifolin is a flavonol glycoside natural product,is a potential inhibitor of adenosine deaminase (Ki of 49.92 μM). Hibifolin protects neurons against beta-amyloid-induced neurotoxicity.

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Hibifolin, CAS 55366-56-8

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Hibifolin is a flavonol glycoside natural product,is a potential inhibitor of adenosine deaminase (Ki of 49.92 μM). Hibifolin protects neurons against beta-amyloid-induced neurotoxicity.
Targets&IC50	ADA:49.92 μM (Ki)
In vitro	the inhibitory activity of a plant flavonoid, hibifolin on ADA is investigated using enzyme kinetic assay and isothermal titration calorimetry.?The inhibitory constant of hibifolin was found to be 49.92μM 3.98 and the mode of binding was reversible.?Isothermal titration calorimetry showed that the compound binds ADA with binding energy of -7.21Kcal/mol.?The in silico modeling and docking studies showed that the bound ligand is stabilized by hydrogen bonds with active site residues of the enzyme.?hibifolin can act as a potential inhibitor of ADA.

Synonyms	棉皮素-8-O-Β-D-葡萄糖醛酸苷, 棉花皮素-8-O-葡萄糖醛酸苷
Molecular Weight	494.36
Formula	C21H18O14
CAS No.	55366-56-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 5 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Arun K G , Sharanya C S , Sandeep P M , et al. Inhibitory activity of hibifolin on adenosine deaminase- experimental and molecular modeling study[J]. Computational Biology & Chemistry, 2016, 64:353-358.

Related compound libraries

This product is contained In the following compound libraries：

Flavonoid Natural Product Library Traditional Chinese Medicine Monomer Library Neurotransmitter Receptor Compound Library Inhibitor Library Polyphenolic Natural Product Library Natural Product Library for HTS Neuronal Signaling Compound Library Bioactive Compound Library Selected Plant-Sourced Compound Library

Related Products

Related compounds with same targets

Hibifolin 8-Azaadenosine Pentostatin Cladribine Erdosteine

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Keywords

Hibifolin 55366-56-8 代谢 Adenosine deaminase Adenosine Deaminase adenosine anti-proliferative anti-inflammatory neurotoxicity Inhibitor deaminase inhibit inhibitor

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