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CGP71683 hydrochloride

Catalog No. T5587 CAS 192322-50-2

Synonyms: CGP71683A

CGP71683 hydrochloride (CGP71683A) is a competitive neuropeptide Y5 receptor antagonist (Ki: 1.3 nM) and shows no obvious activity at Y1 receptor (Ki <4000 nM) and Y2 receptor (Ki: 200 nM) in cell membranes.

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CGP71683 hydrochloride Chemical Structure

CGP71683 hydrochloride, CAS 192322-50-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
2 mg	In stock	$ 68.00
5 mg	In stock	$ 107.00
10 mg	In stock	$ 162.00
25 mg	In stock	$ 269.00
50 mg	In stock	$ 393.00
100 mg	In stock	$ 598.00
1 mL * 10 mM (in DMSO)	In stock	$ 119.00

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Purity: 99.82%

Biological Description

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Storage & Solubility Information

Description	CGP71683 hydrochloride (CGP71683A) is a competitive neuropeptide Y5 receptor antagonist (Ki: 1.3 nM) and shows no obvious activity at Y1 receptor (Ki >4000 nM) and Y2 receptor (Ki: 200 nM) in cell membranes.
Targets&IC50	Y2 receptor:200 nM (Ki), Y5 receptor:1.3 nM (Ki), Y1 receptor:>4000 nM (Ki)
In vivo	CGP71683 (1-10 mg/kg, i.p.) dose-dependently decreased nocturnal and fasting-induced food intake. CGP71683A did not have an anxiogenic-like effect in the rat social interaction test. In the open-field test, carried out immediately after the elevated plus-maze test, CGP71683A inhibited horizontal and vertical activity [2].

Synonyms	CGP71683A
Molecular Weight	512.07
Formula	C26H30ClN5O2S
CAS No.	192322-50-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL (234.34 mM)

H2O: 10 mg/mL (19.53 mM)

References and Literature

1. Lecklin A, et al. Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig. Br J Pharmacol. 2002 Apr;135(8):2029-37. 2. Kask A, et al. Neuropeptide Y Y(5) receptor antagonist CGP71683A: the effects on food intake and anxiety-related behavior in the rat. Eur J Pharmacol. 2001 Mar 2;414(2-3):215-24.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library GPCR Compound Library Neuronal Signaling Compound Library Bioactive Compound Library Bioactive Compounds Library Max Neurotransmitter Receptor Compound Library NO PAINS Compound Library

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M40 acetate(143896-17-7 free base) Pancreatic Polypeptide (human) acetate Ala5-Galanin (2-11) BWX 46 Acetate M617 acetate CYM2503 AC-099 hydrochloride HT-2157

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

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