Search Result

Search Results for " ki-1 "

Targets

893

Compounds

Natural Products

1750

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T4315	Ki20227		c-Fms , VEGFR , CSF-1R , PDGFR , c-Kit
	Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRβ(IC50: 451/217 nM), respectively.		c-Fms , VEGFR , CSF-1R , PDGFR , c-Kit
T8312	Derenofylline		Adenosine Receptor
	Derenofylline is a selective and potent adenosine A(1) antagonist in vitro (Ki=1 nM)		Adenosine Receptor
T6366	A-966492		PARP
	A-96649 is a new-type and effective inhibitor. The Ki of A-966492 for PARP1 and PARP2 is 1 nM and 1.5 nM, respectively.		PARP
T7662	α-Demethylnaproxen		COX
	α-Demethylnaproxen is a competitive inhibitor of COX(Ki values of 21 and 19 μM for ovine COX-1 and -2, respectively)		COX
T6312	R547	Ro 4584820	Apoptosis , GSK-3 , PKA , CDK
	R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1.		Apoptosis , GSK-3 , PKA , CDK
T37042	SCH529074	SCH 529074	p53
	SCH529074 is a selective activator of p53 (Ki = 1 μM) and can be used in studies about non-small-cell lung carcinoma. SCH529074 restores mutant p53 function and interrupts HDM2-mediated ubiquitination of wild Type p53.		p53
T2101	Navitoclax	ABT-263	BCL
	Navitoclax (ABT-263) is a Bcl-2 inhibitor that binds to Bcl-xL, Bcl-2, and Bcl-w proteins (Ki<1 nM) with potent and oral activity. Navitoclax has antitumor activity and induces apoptosis.		BCL
T70407	Cemadotin free base	LU103793 free base	Microtubule Associated
	Cemadotin free base(LU103793 free base) is a novel anti-limiting peptide , an analog of Dolastatin 15, a naturally occurring cytotoxic peptide that blocks mitosis and inhibits microtubules (tubulin) with a Ki of 1 μM. Ce...		Microtubule Associated
T6574	Lumiracoxib	Prexige,COX-189	COX
	Lumiracoxib (Prexige) is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.		COX
T3080	Pyridone 6	Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,JAK Inhibitor I	Tyrosine Kinases , JAK
	Pyridone 6 (JAK Inhibitor)(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); displaying significantly weaker affinities (130 nM to 10 mM...		Tyrosine Kinases , JAK
T37696	NOS1-IN-1	nNOS Inhibitor I	NOS
	NOS1-IN-1（nNOS Inhibitor I） is a potent, selective and cell permeable nNOS inhibitor (Ki: 120 nM).NOS1-IN-1 has a Ki value of 39 μM for eNOS and 325 μM for iNOS.NOS1-IN-1 can be used for the study of neurological disorde...		NOS
T4167	Raf inhibitor 1 dihydrochloride	B-Raf inhibitor 1 dihydrochloride	Raf
	Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) is a potent and selective B-Raf inhibitor.		Raf
T1865	S1RA	E-52862	Sigma receptor
	S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating significant selectivity over the sigma-2 receptor (σ2R, Ki > 1000 nM).		Sigma receptor
T12306	OMDM-5		Cannabinoid Receptor , Endogenous Metabolite , TRP/TRPV Channel
	OMDM-5 is a selective anandamide cellular uptake (ACU)inhibitor(Ki of 4.8 μM).
T12912	Sigma-1 receptor antagonist 3		Sigma receptor , HER
	Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain.		Sigma receptor , HER
T12911	Sigma-1 receptor antagonist 2		Sigma receptor
	Sigma-1 receptor antagonist 2 is a potent and selective antagonist of sigma 1 receptor (σ1 R) (σ1 and σ2 receptor with Kis of 3.88 and 1288 nM , respectively).		Sigma receptor
T3101	NQDI-1	NQDI1,NQDI 1	Apoptosis , ASK , MAPK
	NQDI-1 (NQDI 1) is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50/Ki: 3 μM/500 nM).		Apoptosis , ASK , MAPK
T14151	AKR1C1-IN-1		NADPH
	AKR1C1-IN-1 is a human 20α-hydroxysteroid dehydrogenase (AKR1C1) inhibitor (Ki: 4 nM for AKR1C1).		NADPH
T9983	CCR8 antagonist 1	LUN04765	CCR
	CCR8 antagonist 1 is an antagonist of C-C Motif Chemokine Receptor 8 (CCR8) with a Ki value of 1.6 nM.		CCR
T2493	PD 151746		Cysteine Protease , Proteasome
	PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0.03 μM (Ki for μ-calpain) and 5.33 ± 0.77 μM (Ki for m-calp...		Cysteine Protease , Proteasome
T4229	S1RA hydrochloride	E-52862 hydrochloride	Sigma receptor
	S1RA hydrochloride (E-52862 hydrochloride) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki > 1000 nM).		Sigma receptor
T2074	Raf inhibitor 1	B-Raf inhibitor 1	Raf
	B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.		Raf
T15364	G-1		Estrogen Receptor/ERR , GPR
	G-1 is a nonsteroidal, high-affinity and selective GPR30 agonist (Ki: 11 nM).		Estrogen Receptor/ERR , GPR
T10053	5HT6-ligand-1		5-HT Receptor
	5HT6-ligand-1 is an orally active ligand of 5-HT6 receptor (Ki = 1.43 nM).		5-HT Receptor
TP1011L	ACTH (1-17) acetate		Melanocortin Receptor
	ACTH (1-17) acetate is a potent agonist at the human melanocortin 1 (MC1) receptor with high affinity(Ki = 0.21 nM).		Melanocortin Receptor
T15020	CU-CPT22		TLR
	CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2. CU-CPT22 binds at the interface of TLR1 and TLR2 (IC50 = 0.58 μM). It competes with the synthetic triacylated lipoprotein (Pam3CSK4) ...		TLR
T6400	AZD3514		Androgen Receptor
	AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.		Androgen Receptor
T11909	LY2444296	FP3FBZ	Opioid Receptor
	LY2444296 (FP3FBZ) is an orally active and selective antagonist of kappa opioid receptor(Ki = 1 nM).		Opioid Receptor
T2375	BX471	BX 471,BX-471,ZK-811752	CCR
	BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist.		CCR
T12010	Aurora B inhibitor 1		Aurora Kinase
	Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki <0.010 uM) with potential anticancer activity for cancer research.		Aurora Kinase
TP1772L	Hemokinin 1 (mouse) acetate(208041-90-1 free base)		Neurokinin receptor
	Hemokinin 1 (mouse) acetate is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 receptor.		Neurokinin receptor
T10723	CDC25B-IN-1	ethyl 3-[(3-methoxynaphthalen-1-yl)amino]benzoate	Phosphatase
	CDC25B-IN-1 is an inhibitor of CDC25B with a Ki of 8.5 μM. CDC25B-IN-1 increases the G2/M phase by inhibiting cell proliferation and colony formation.		Phosphatase
T4523	TP-3654		Pim
	TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).		Pim
T78825	D4R agonist-1		Dopamine Receptor
	D4R agonist-1 is a selective and potent D4R partial agonist (Ki:2.2 nM).D4R agonist-1 can be used to study neurological diseases.		Dopamine Receptor
T2632	A-1210477		Apoptosis , BCL
	A-1210477 is an effective and specific MCL-1 and Bcl-2 inhibitor (Ki/IC50: 0.454/26.2 nM).		Apoptosis , BCL
T5169	SGC-GAK-1		Serine/threonin kinase
	SGC-GAK-1 is a selective cyclin G-associated kinase (GAK) inhibitor (Ki: 3.1 nM).		Serine/threonin kinase
T6281	TW-37	TW 37	BCL
	TW-37 is an nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 (Ki: 0.29/1.11/0.26 μM).		BCL
T6585	SAR405838	MI773,MI 773,MI-77301,MI-773	Mdm2 , E1/E2/E3 Enzyme
	MI-773 (SAR405838 (MI 773)) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.		Mdm2 , E1/E2/E3 Enzyme
T6905	Netupitant	Ro 67-31898/000,CID 6451149	Neurokinin receptor
	Netupitant (CID 6451149) is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM).		Neurokinin receptor
T15750	Ligandrol	LGD-4033	Androgen Receptor
	Ligandrol is a novel nonsteroidal, oral SARM that binds to the androgen receptor with high affinity (Ki: 1 nM) and selectivity.		Androgen Receptor
T2710	TCS 1102		OX Receptor
	TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).		OX Receptor
TP1882L1	Orphanin FQ(1-11) acetate(178249-41-7 free base)		Opioid Receptor
	Orphanin FQ(1-11) acetate(178249-41-7 free base) is a peptide fragment containing amino acids 1-11 of Nociceptin. Orphanin FQ(1-11) acetate(178249-41-7 free base) is a potent agonist of the ORL1/KOR-3 receptor (Ki = 55 n...		Opioid Receptor
T61278	Aminopeptidase-IN-1		Aminopeptidase
	Aminopeptidase-IN-1 is a potent inhibitor of insulin-regulated aminopeptidase (IRAP) (Ki: 7.7 μM).Aminopeptidase-IN-1 can be used in studies of cognitive and memory disorders.		Aminopeptidase
T60454	NDM-1 inhibitor-3		Others
	NDM-1 inhibitor-3 is a New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor (Ki : 4 μM) widely found in nature and is associated with antibiotic resistance.		Others
T16118	MLS0315771		Others
	MLS0315771 is an effective and biologically active competitive phosphomannose isomerase (MPI) inhibitor (IC50: ~1 μM and a Ki: 1.4 μM).		Others
T6034	UMI-77	UMI77,UMI 77	BCL
	UMI-77, a specific Mcl-1 inhibitor (Ki: 490 nM), has selectivity over other members of Bcl-2 family.		BCL
T5996	CB1-IN-1	DBPR211	Cannabinoid Receptor
	CB1-IN-1 (DBPR211) is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.		Cannabinoid Receptor
T12110	MRZ 2-514	8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one	NMDAR
	MRZ 2-514 (8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one) is a strychnine-insensitive modulatory site of the NMDA receptor (glycineB)antagonist with Ki of 33 μM.		NMDAR
T8824	CRBN modulator-1	WUN29654	Others , Ligand for E3 Ligase
	CRBN modulator-1 (WUN29654) is a Thalidomide analog and CRBN modulator,has an IC50 of 3.5 μM and a Ki of 0.98 μM.		Others , Ligand for E3 Ligase
T7488	BD1063 dhydrochloride	BD1063	Sigma receptor
	BD1063 dhydrochloride is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).		Sigma receptor

Compounds

Ki20227

T4315

Synonym:

Target: c-Fms, VEGFR, CSF-1R, PDGFR, c-Kit

Derenofylline

T8312

Synonym:

Target: Adenosine Receptor

Target: Apoptosis, GSK-3, PKA, CDK

Synonym: LU103793 free base

Target: Microtubule Associated

Lumiracoxib

T6574

Synonym: Prexige,COX-189

Target: COX

Pyridone 6

T3080

Synonym: Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,JAK Inhibitor I

Target: Tyrosine Kinases, JAK

NOS1-IN-1

T37696

Synonym: nNOS Inhibitor I

Target: NOS

Raf inhibitor 1 dihydrochloride

T4167

Synonym: B-Raf inhibitor 1 dihydrochloride

Target: Sigma receptor

OMDM-5

T12306

Synonym:

Target: Cannabinoid Receptor, Endogenous Metabolite, TRP/TRPV Channel

Sigma-1 receptor antagonist 3

T12912

Synonym:

Target: Sigma receptor, HER

Sigma-1 receptor antagonist 2

T12911

Synonym:

Target: Sigma receptor

NQDI-1

T3101

Synonym: NQDI1,NQDI 1

Target: Apoptosis, ASK, MAPK

Target: Cysteine Protease, Proteasome

S1RA hydrochloride

T4229

Synonym: E-52862 hydrochloride

Target: Sigma receptor

Raf inhibitor 1

T2074

Synonym: B-Raf inhibitor 1

Target: Estrogen Receptor/ERR, GPR

5HT6-ligand-1

T10053

Synonym:

Target: 5-HT Receptor

ACTH (1-17) acetate

TP1011L

Synonym:

Target: Melanocortin Receptor

Target: Androgen Receptor

LY2444296

T11909

Synonym: FP3FBZ

Target: Opioid Receptor

BX471

T2375

Synonym: BX 471,BX-471,ZK-811752

Target: Aurora Kinase

Hemokinin 1 (mouse) acetate(208041-90-1 free base)

TP1772L

Synonym:

Target: Neurokinin receptor

CDC25B-IN-1

T10723

Synonym: ethyl 3-[(3-methoxynaphthalen-1-yl)amino]benzoate

Target: Dopamine Receptor

A-1210477

T2632

Synonym:

Target: Apoptosis, BCL

SGC-GAK-1

T5169

Synonym:

Target: Serine/threonin kinase

Synonym: MI773,MI 773,MI-77301,MI-773

Target: Mdm2, E1/E2/E3 Enzyme

Netupitant

T6905

Synonym: Ro 67-31898/000,CID 6451149

Target: Neurokinin receptor

Ligandrol

T15750

Synonym: LGD-4033

Target: Androgen Receptor

Orphanin FQ(1-11) acetate(178249-41-7 free base)

TP1882L1

Synonym:

Target: Opioid Receptor

Aminopeptidase-IN-1

T61278

Synonym:

Target: Aminopeptidase

Synonym: UMI77,UMI 77

Target: Cannabinoid Receptor

MRZ 2-514

T12110

Synonym: 8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one

Target: Others, Ligand for E3 Ligase

BD1063 dhydrochloride

T7488

Synonym: BD1063

Target: Sigma receptor

Cat No.	Product Name	Synonyms	Targets
T8260	4',5-Dihydroxyflavone		Lipoxygenase , Glucosidase
	4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).		Lipoxygenase , Glucosidase
TN1160	1,2,3,6-Tetragalloylglucose	1,2,3,6-Tetra-O-galloyl-β-D-glucose,TeGG	LDL , UGT
	1,2,3,6-Tetragalloylglucose (TeGG) has antioxidative activity, it also shows the most potent anticomplement activity (IC50 = 34 microM). 1,2,3,6-Tetragalloylglucose is also a potent inhibitor of UDP glucuronosyltransfera...		LDL , UGT
T4429	Rauwolscine hydrochloride	Corynanthidine hydrochloride,α-Yohimbine hydrochloride,Isoyohimbine hydrochloride	Adrenergic Receptor
	Rauwolscine hydrochloride (Isoyohimbine hydrochloride) , a natural alkaloid, is a specific and reversible α2-adrenergic receptor antagonist (Ki: 12 nM) [1]. It is a stereoisomer of yohimbine, which potently antagonizes b...		Adrenergic Receptor
T5S0669	Bergamottin	5-Geranoxypsoralen,Bergamotine,Bergaptin	P450
	1. Bergamottin (5-Geranoxypsoralen) can significantly reduce blood glucose and increase glucose tolerance and insulin sensitivity in KK-A<sup>y</sup>diabetic mice.		P450
T4S0145	Corylifol A	Corylinin	hCE , STAT , UGT
	1. Corylifol A (Corylinin) displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. 2. Corylifol A and Biochanin A can be the potentia...		hCE , STAT , UGT
T5S0994	N-Methylcytisine	Caulophylline	Others , AChR
	1. N-Methylcytisine (Caulophylline)'s nicotinic receptors have high affinity (KD = 5 nM)to nAChR from squid optical ganglia. 2. N-Methylcytisine and N, N-dimethylcytisine did not displace 14C-tubocurarine at a concentrat...		Others , AChR
T4S0051	Coptisine sulfate		Indoleamine 2,3-Dioxygenase (IDO)
	1. Coptisine sulfate has growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program.		Indoleamine 2,3-Dioxygenase (IDO)
T7472	7-Hydroxyflavone		P450
	7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2.with anti-inflammatory activity		P450
TN1051	1-Caffeoylquinic acid		NF-κB
	1-Caffeoylquinic acid is an important intermediate in lignin biosynthesis. 1-Caffeoylquinic acid has anti-influenza, and antioxidant activities, it also slows the release of glucose into the bloodstream after a meal.		NF-κB
T2730	Gossypol (acetic acid)	(±)-Gossypol-acetic acid,Pogosin,AT101,Gossypol acetic acid	BCL
	Gossypol acetic acid (AT101), a polyphenolic compound isolated from cottonseeds, binds with Bcl-2, Bcl-xL, Mcl-1, and does not inhibit BIR3 domain and BID.		BCL
T5S0056	Coptisine chloride	Q-100696,NSC-119754	Indoleamine 2,3-Dioxygenase (IDO) , Influenza Virus , Antibacterial
	1. Coptisine chloride (NSC-119754) can be absorbed across intestinal epithelial cells, and completely absorbed compounds.
T5S2017	Ingenol	(-)-Ingenol	PKC
	1. Ingenol ((-)-Ingenol) mebutate is an effective treatment for actinic keratosis. 2. Formulating novel derivatives from Ingenol esters may be an innovative approach to develop new lead compounds to reactivate latent HIV...		PKC
T5558	Chelidonic acid	Jervaic acid,Jerva acid,γ-Pyrone-2,6-dicarboxylic acid	NF-κB , Caspase
	Chelidonic acid (Jervaic acid) is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid (Jervaic acid) also shows anti-inflammatory activity...		NF-κB , Caspase
T5S0053	Coptisine	Coptisin	Indoleamine 2,3-Dioxygenase (IDO)
	1. Coptisine (Coptisin) treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myocardial I/R likely through suppressing myocardial ...		Indoleamine 2,3-Dioxygenase (IDO)
T6323	Oligomycin A	MCH 32	ATPase , Antibiotic , Antifungal
	Oligomycin A (MCH 32) is an inhibitor of ATP synthase, inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitochondria.		ATPase , Antibiotic , Antifungal
T21504	γ-Linolenic Acid methyl ester	Methyl gamma-linolenate	LTR
	γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) is a weak leukotriene B4 (LTB4) receptor antagonist.		LTR
T5S1172	Tiliroside	Tribuloside	Antioxidant
	1. Tiliroside (Tribuloside) shows anticarcinogenic activity. 2. Tiliroside shows hepatoprotective activity. 3. Tiliroside shows antioxidant and anti-inflammatory activity, can inhibit neuroinflammation in neurodegenerati...		Antioxidant
T0683	Mevastatin	Compactin,ML236B	Apoptosis , Antibacterial , Antibiotic , HMG-CoA Reductase , Autophagy , Lipid
	Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials.
T4861	Trans-Aconitic acid		ATPase , Endogenous Metabolite
	Trans-Aconitic acid is normally present in normal human urine, and it has been suggested that is present in larger amounts with Reye's syndrome and organic aciduria. trans-Aconitic acid is a substrate of enzyme trans-aco...		ATPase , Endogenous Metabolite
T16896	SL 0101-1	SL0101	S6 Kinase
	SL 0101-1 (SL0101) is a selective, efficient, reversible and ATP-competitive inhibitor of p90 ribosomal S6 kinase (RSK) that can permeate cell membranes, with an IC50 value of 89 nM for RSK.SL 0101-1 (SL0101) is also a p...		S6 Kinase
T71833	Acetylaszonalenin
	Acetylaszonalenin is a fungal metabolite that has been found in A. flavipes.1 It acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P with a Ki value of 170 μM.
T14121	Actinonin	(-)-Actinonin	Aminopeptidase
	Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM, it also is an apoptosis inducer. Actinonin ...		Aminopeptidase
T72172	4,6-O-Ethylidene-α-D-glucose	Ethylidene-glucose
	4,6-O-Ethylidene-α-D-glucose (Ethylidene-glucose), a derivative of glucose, serves as a competitive inhibitor for the exofacial binding site of glucose transporter 1 (GLUT1), exhibiting a Ki of 12 mM against wild-type 2-...
T74198	Beauverolide Ja
	Beauverolide Ja, a cyclotetradepsipeptide and secondary metabolite of Isaria fumosorosea [1], functions as a potent inhibitor of calmodulin (CaM), exhibiting a dissociation constant (Kd) of 0.078 μM and an inhibition con...
T38241	2-Aminoimidazole
	2-Aminoimidazole is a potent antibiofilm agent and adjuvant to antimicrobial treatments, which effectively disrupts bacterial self-protection mechanisms by inhibiting biofilm formation and genetically-encoded antibiotic ...
TN4613	(-)-N-methylcoclaurine	N-Methylcoclaurine	Others
	N-Methylcoclaurine shows binding affinities for the ĸ opioid receptor with the equilibrium dissociation constant (Ki) value of 0.9 ± 0.1 uM. N-methylcoclaurine also shows promising butyrylcholinesterase inhibition a...		Others
T35770	Cylindrospermopsin
	Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of ...
T75644	Lupanine hydrochloride
	Lupanine hydrochloride, a natural ketonic derivative of Sparteine ((+)-Sparteine), exhibits ganglioplegic activity and binds to the nicotinic receptor (nAChR) with a K i value of 500 nM [1].
T75541	Tanshinone IIA anhydride
	Tanshinone IIA anhydride is a potent, irreversible inhibitor of human carboxylesterase (CE), exhibiting inhibitory constants (K i values) of 1.9 nM for human CE1 and 1.4 nM for human intestinal CE (hiCE), respectively [1...
T73857	Mesembrine
	Mesembrine ((+)-Mesembrine), a primary alkaloid distinguished by its aryloctahydroindole structure, acts as a potent 5-HT transporter inhibitor with an inhibition constant (K i) of 1.4 nM. Additionally, it demonstrates i...
T83915	Norbixin hydrate
	Norbixin, a carotenoid found in B. orellana, exhibits various biological activities including binding to the peroxisome proliferator-activated receptor γ (PPARγ) with a Ki of 1.15 µM in a cell-free assay. At a dosage of ...
T35624	Ajoene
	Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs =...

Natural Products

4',5-Dihydroxyflavone

T8260

Synonym:

Target: Lipoxygenase, Glucosidase

1,2,3,6-Tetragalloylglucose

TN1160

Synonym: 1,2,3,6-Tetra-O-galloyl-β-D-glucose,TeGG

Target: LDL, UGT

Rauwolscine hydrochloride

T4429

Synonym: Corynanthidine hydrochloride,α-Yohimbine hydrochloride,Isoyohimbine hydrochloride

Target: Adrenergic Receptor

Bergamottin

T5S0669

Synonym: 5-Geranoxypsoralen,Bergamotine,Bergaptin

Target: hCE, STAT, UGT

N-Methylcytisine

T5S0994

Synonym: Caulophylline

Target: Indoleamine 2,3-Dioxygenase (IDO)

1-Caffeoylquinic acid

TN1051

Synonym:

Target: NF-κB

Gossypol (acetic acid)

T2730

Synonym: (±)-Gossypol-acetic acid,Pogosin,AT101,Gossypol acetic acid

Target: BCL

Coptisine chloride

T5S0056

Synonym: Q-100696,NSC-119754

Target: Indoleamine 2,3-Dioxygenase (IDO), Influenza Virus, Antibacterial

Synonym: Jervaic acid,Jerva acid,γ-Pyrone-2,6-dicarboxylic acid

Target: NF-κB, Caspase

Coptisine

T5S0053

Synonym: Coptisin

Target: Indoleamine 2,3-Dioxygenase (IDO)

Oligomycin A

T6323

Synonym: MCH 32

Target: ATPase, Antibiotic, Antifungal

γ-Linolenic Acid methyl ester

T21504

Synonym: Methyl gamma-linolenate

Synonym: Compactin,ML236B

Target: Apoptosis, Antibacterial, Antibiotic, HMG-CoA Reductase, Autophagy, Lipid

trans-Aconitic acid

T4861

Synonym:

Target: ATPase, Endogenous Metabolite

Synonym: (-)-Actinonin

Target: Aminopeptidase

4,6-O-Ethylidene-α-D-glucose

T72172

Synonym: Ethylidene-glucose

(-)-N-methylcoclaurine

TN4613

Synonym: N-Methylcoclaurine

Lupanine hydrochloride

T75644

Synonym:

Target:

Tanshinone IIA anhydride

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01827	CD30/TNFRSF8 Protein, Human, Recombinant (His)	Human	HEK293
	CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated, but not resting, T and B cells. CD30 can regulate proliferation of...
TMPY-05443	CD30/TNFRSF8 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated, but not resting, T and B cells. CD30 can regulate proliferation of...
TMPY-05737	CD30/TNFRSF8 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated, but not resting, T and B cells. CD30 can regulate proliferation of...
TMPY-04113	KRAS Protein,Human,Recombinant(G12D & Q61H, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-04116	KRAS Protein,Human,Recombinant(G12C & Q61H, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPJ-01436	MKI67 Protein, Human, Recombinant (GST)	Human	E. coli
	MKI67 also also known as Ki67, is a 350-400 kDa nuclear protein that belongs to a molecular group comprised of mitotic chromosome-associated proteins. MKI67 contains 1 FHA domain and plays a key role in cell proliferatio...
TMPY-05471	CD30/TNFRSF8 Protein, Human, Recombinant (hFc)	Human	HEK293
	CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated, but not resting, T and B cells. CD30 can regulate proliferation of...
TMPY-01888	KRAS Protein,Human, Recombinant (Q61H, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-06056	KRAS Protein, Human, Recombinant (G12D, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-06430	CD30/TNFRSF8 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated, but not resting, T and B cells. CD30 can regulate proliferation of...
TMPY-06282	CD30/TNFRSF8 Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	HEK293
	CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated, but not resting, T and B cells. CD30 can regulate proliferation of...
TMPY-05118	CD30/TNFRSF8 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
	CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated, but not resting, T and B cells. CD30 can regulate proliferation of...
TMPY-03105	Ki67/MKI67 Protein, Human, Recombinant (GST)	Human	E. coli
	MKI67 contains 1 FHA domain and plays a key role in cell proliferation. During interphase, the MKI67 antigen can be exclusively detected within the cell nucleus, whereas in mitosis most of the protein is relocated to the...
TMPJ-00341	CD30/TNFRSF8 Protein, Human, Recombinant (aa 19-379, hFc)	Human	Human Cells
	CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family, which regulates proliferation/apoptosis and antibody responses. CD30 is expressed by activated, but not by resting, T ...
TMPJ-00240	CAMK1 Protein, Human, Recombinant (His)	Human	Human Cells
	Calcium/Calmodulin-Dependent Protein Kinase Type 1 (CAMK1) belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, and CaMK subfamily. CAMK1 contains one protein kinase domain and widely expressed....
TMPJ-00342	CD30/TNFRSF8 Protein, Human, Recombinant (aa 19-379, His)	Human	Human Cells
	CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family, which regulates proliferation/apoptosis and antibody responses. CD30 is expressed by activated, but not by resting, T ...
TMPJ-00343	CD30/TNFRSF8 Protein, Human, Recombinant (mFc)	Human	Human Cells
	CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family, which regulates proliferation/apoptosis and antibody responses. CD30 is expressed by activated, but not by resting, T ...
TMPJ-00340	CD30/TNFRSF8 Protein, Human, Recombinant (aa 19-379, His & Avi), Biotinylated	Human	Human Cells
	CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family, which regulates proliferation/apoptosis and antibody responses. CD30 is expressed by activated, but not by resting, T ...
TMPY-06345	KRAS Protein, Human, Recombinant (His & Avi), Biotinylated	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPU-00001	KRAS Protein, Human, Recombinant (G12S, GST)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. As other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes becau...
TMPY-06138	KRAS Protein, Human, Recombinant (61Q, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-03754	SCLY Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	SCLY, also known as selenocysteine lyase, belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. It is a novel enzyme that exclusively decomposes L-selenocysteine into L-alanine and H2Se in various...
TMPY-04451	AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus-Insect Cells
TMPY-03878	Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)	Human	HEK293
	Integrin alpha-5, also known as ITGA5, is a single-pass type I membrane protein which belongs to the integrin alpha chain family. ITGA5 contains 7 FG-GAP repeats. Alpha chain 5 undergoes post-translational cleavage in th...
TMPY-02501	CD3D & CD3E Heterodimer Protein, Human, Recombinant	Human	HEK293
	CD3D & CD3E Heterodimer Protein, Human, Recombinant is expressed in HEK293 cells.
TMPY-03745	CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His)	Human	HEK293
	CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 with Flag and His tag. The predicted molecular weight is 31.05 kDa. Accession number: P04234-1&P07766-1
TMPY-02794	TLR2 Protein, Human, Recombinant (aa 1-587, His)	Human	Baculovirus-Insect Cells
	TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They play a fundamental role in pathoge...
TMPY-03947	CD48 Protein, Human, Recombinant (hFc)	Human	HEK293
	Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfamily molecules. CD2 and 2B4 (CD244) are known ligands for CD4...
TMPY-03481	IL-1R2 Protein, Human, Recombinant	Human	HEK293
	Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interl...
TMPK-00114	C-Reactive Protein /CRP Protein, Human, Recombinant (His)	Human	HEK293
	C-reactive protein (CRP) is a polypeptide molecule belonging to the family of pentraxins. CRP is synthesized primarily by the liver in response to certain pro-inflammatory cytokines. It plays an important role in innate ...
TMPY-00740	SDF-1 Protein, Human, Recombinant (hFc)	Human	HEK293
	The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPY-04384	Src Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C...
TMPK-01151	MXRA8 Protein, Human, Recombinant (His)	Human	HEK293
	Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses.
TMPK-01074	CD163 Protein, Human, Recombinant (His & Avi)	Human	HEK293
	The hemoglobin (Hb) scavenger receptor, CD163, is a macrophage-specific protein and the upregulated expression of this receptor is one of the major changes in the macrophage switch to alternative activated phenotypes in ...
TMPK-00383	ACE2/ACEH Protein, Human, Recombinant (His & Avi)	Human	HEK293
	ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angio...
TMPY-02525	RGMA Protein, Human, Recombinant (His)	Human	HEK293
	RGMa, also known as RGM domain family, member A, belongs to the RGM (repulsive guidance molecule) family whose members are membrane-associated glycoprotein. RGMa is a glycosylphosphatidylinositol-anchored glycoprotein th...
TMPY-04753	IRE1 Protein, Human, Recombinant (aa 465-977)	Human	Baculovirus-Insect Cells
	Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ...
TMPY-04413	IRE1 Protein, Human, Recombinant (aa 465-977, His & GST)	Human	Baculovirus-Insect Cells
	Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ...
TMPK-01393	Tenascin Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Tenascin-C (TNC) is a hexameric, multimodular extracellular matrix protein with several molecular forms that are created through alternative splicing and protein modifications. It is highly conserved amongst vertebrates,...
TMPK-00305	TGFBR1 Protein, Human, Recombinant (mFc & Avi)	Human	HEK293
	transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the sup...
TMPY-01460	ABHD4 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Abhydrolase domain containing 4 (ABHD4), also known as alpha/beta-hydrolase 4 (ABH4) , or lyso-N-acylphosphatidylethanolamine lipase, which belongs to the ABHD4/ABHD5 subfamily of peptidase S33 family. Abhydrolase domain...
TMPY-00978	Progranulin Protein, Human, Recombinant (His)	Human	HEK293
	Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, ...
TMPY-02227	IL-1 beta/IL-1F2 Protein, Rat, Recombinant (mature form)	Rat	E. coli
	Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair ...
TMPY-05526	Siglec-15 Protein, Human, Recombinant (His)	Human	HEK293
	Siglec-15 Protein, Human, Recombinant (His) is expressed in HEK293 cells.
TMPY-01963	IL-21 Protein, Human, Recombinant	Human	E. coli
	IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellul...
TMPY-05781	LILRA6 Protein, Human, Recombinant (His)	Human	HEK293
	LILRA6 Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 47.78 kDa. Accession number: Q6PI73-1
TMPY-06077	LILRA1/LIR-6/CD85i Protein, Human, Recombinant (hFc)	Human	HEK293
	LILRA1/LIR-6/CD85i Protein, Human, Recombinant (hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 75.3 kDa. Accession number: O75019-1
TMPY-05364	CD8 alpha Protein, Human, Recombinant (hFc)	Human	HEK293
	T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been imp...
TMPY-04799	IFNAR2 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
	Interferon-alpha/beta receptor beta chain (IFNAR2) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protei...
TMPY-04970	TIGIT Protein, Human, Recombinant (hFc)	Human	HEK293
	TIGIT, also known as V-set and transmembrane domain-containing protein 3 (VSTM3) or V-set and immunoglobulin domain-containing protein 9 (VSIG9) is a new surface protein containing an immunoglobulin variable domain, a tr...
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