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Mevastatin

Catalog No. T0683 CAS 73573-88-3

Synonyms: Compactin, ML236B

Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials.

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Mevastatin, CAS 73573-88-3

Pack Size	Availability	Price/USD
50 mg	In stock	$ 51.00
100 mg	In stock	$ 77.00
500 mg	In stock	$ 223.00
1 mL * 10 mM (in DMSO)	In stock	$ 54.00

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Purity: 97.96%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials.
Targets&IC50	HMG-CoA reductase:1 nM(ki)
In vitro	Mevastatin competitively inhibits HMG-CoA reductase, subsequently reducing cholesterol synthesis in the liver. After 14 days of high-dose treatment, a more than 30% increase in baseline absolute cerebral blood flow was observed. Oral administration of Mevastatin at doses of 5 mg/kg and 20 mg/kg led to reductions in serum cholesterol levels 3 hours post-administration, with the 20 mg/kg dosage decreasing serum cholesterol by approximately 30%.
In vivo	The bicyclic portion of Mevastatin binds to the active site of coenzyme A. Mevastatin elevates eNOS mRNA and protein levels, reduces infarct size, and ameliorates neurological deficits in a dose- and time-dependent manner. At a concentration of 0.01 pg/mL (26 nM), Mevastatin can reduce cholesterol synthesis by 50% compared with the control group.

Synonyms	Compactin, ML236B
Molecular Weight	390.51
Formula	C23H34O5
CAS No.	73573-88-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 72 mg/mL (184.4 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Endo A, et al. J Antibiot (Tokyo), 1976, 29(12), 1346-1348. 2. Amin-Hanjani S, et al. Stroke, 2001, 32(4), 980-986.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Microbial Natural Product Library Bioactive Lipid Compound Library Anti-Hypertension Compound Library Terpene Natural Product Library Anti-Bacterial Compound Library Human Metabolite Library Glutamine Metabolism Compound Library RO5 Drug-like Natural Product Library

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Keywords

Mevastatin 73573-88-3 Apoptosis Autophagy Metabolism Microbiology/Virology Lipid HMG-CoA Reductase Antibiotic Antibacterial BMP-2 Compactin cardiovascular inhibit phosphorylation lipid-lowering neuroprotection EGFR NF-κB Statins ML236B Bacterial RANKL HMG-CoA Reductase (HMGCR) eNOS Inhibitor inhibitor

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