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Mevastatin

Mevastatin
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Purity:97.96%
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Mevastatin

Catalog No. T0683Cas No. 73573-88-3
Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials.
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Pack SizePrice/USDAvailabilityQuantity
50 mg$51In Stock
100 mg$77In Stock
500 mg$223In Stock
1 mL x 10 mM (in DMSO)$54In Stock
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Product Introduction

Bioactivity
Description
Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials.
In vitro
Mevastatin competitively inhibits HMG-CoA reductase, subsequently reducing cholesterol synthesis in the liver. After 14 days of high-dose treatment, a more than 30% increase in baseline absolute cerebral blood flow was observed. Oral administration of Mevastatin at doses of 5 mg/kg and 20 mg/kg led to reductions in serum cholesterol levels 3 hours post-administration, with the 20 mg/kg dosage decreasing serum cholesterol by approximately 30%.
In vivo
The bicyclic portion of Mevastatin binds to the active site of coenzyme A. Mevastatin elevates eNOS mRNA and protein levels, reduces infarct size, and ameliorates neurological deficits in a dose- and time-dependent manner. At a concentration of 0.01 pg/mL (26 nM), Mevastatin can reduce cholesterol synthesis by 50% compared with the control group.
AliasCompactin, ML236B
Chemical Properties
Molecular Weight390.51
FormulaC23H34O5
Cas No.73573-88-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 72 mg/mL (184.4 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5608 mL12.8038 mL25.6075 mL128.0377 mL
5 mM0.5122 mL2.5608 mL5.1215 mL25.6075 mL
10 mM0.2561 mL1.2804 mL2.5608 mL12.8038 mL
20 mM0.1280 mL0.6402 mL1.2804 mL6.4019 mL
50 mM0.0512 mL0.2561 mL0.5122 mL2.5608 mL
100 mM0.0256 mL0.1280 mL0.2561 mL1.2804 mL

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