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Mevastatin

Catalog No. T0683 CAS 73573-88-3

Synonyms: ML236B, 美伐他汀, Compactin

Mevastatin is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials.

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Mevastatin, CAS 73573-88-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Mevastatin is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials.
Targets&IC50	HMGCR (HMG-CoA reductase:1 nM(ki)

Synonyms	ML236B, 美伐他汀, Compactin
Molecular Weight	390.51
Formula	C23H34O5
CAS No.	73573-88-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 72 mg/mL (184.4 mM)

Ethanol: <1 mg/mL

H2O: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Endo A, et al. J Antibiot (Tokyo), 1976, 29(12), 1346-1348. 2. Amin-Hanjani S, et al. Stroke, 2001, 32(4), 980-986.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Autophagy Compound Library Terpene Natural Product Library Anti-Cancer Metabolism Compound Library Anti-Cardiovascular Disease Compound Library Anti-Obesity Compound Library Antibiotics Library Lipid Metabolism Compound Library Glutamine Metabolism Compound Library Inhibitor Library

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Mevastatin 73573-88-3 代谢凋亡微生物学自噬 Antibacterial Antibiotic Apoptosis Autophagy HMG-CoA Reductase Lipid BMP-2 cardiovascular inhibit phosphorylation lipid-lowering neuroprotection EGFR NF-κB Statins ML236B Bacterial RANKL HMG-CoA Reductase (HMGCR) eNOS Compactin Inhibitor inhibitor

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