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Raf inhibitor 1

Catalog No. T2074 CAS 1093100-40-3

Synonyms: B-Raf inhibitor 1

B-<a href="/target/Raf" style="display: inline; color: #c13a36">Raf</a> inhibitor 1 is a potent and selective B-<a href="/target/Raf" style="display: inline; color: #c13a36">Raf</a> inhibitor.

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Raf inhibitor 1, CAS 1093100-40-3

Pack Size	Availability	Price/USD
2 mg	In Stock (ship within 1 week)	$ 50.00
5 mg	In Stock (ship within 1 week)	$ 90.00
10 mg	In Stock (ship within 1 week)	$ 155.00
25 mg	In Stock (ship within 1 week)	$ 280.00
1 mL * 10 mM (in DMSO)	In Stock (ship within 1 week)	$ 99.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor.
Targets&IC50	B-Raf V600E:1 nM (Ki), B-Raf:1 nM (Ki), C-Raf:0.3 nM (Ki)

Synonyms	B-Raf inhibitor 1
Molecular Weight	478.94
Formula	C26H19ClN8
CAS No.	1093100-40-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 53 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Wang X, et al. J Med Chem. 2012 Sep 13;55(17): 7332-41.

Related Products

Related compounds with same targets

Griffipavixanthone Pseudoginsenoside Rh2 I-37 GSK1904529A MCP110 Raf inhibitor 1 6H05 LY2452473

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Raf inhibitor 1 1093100-40-3 MAPK Raf Raf kinases Raf inhibitor-1 inhibit B-Raf inhibitor 1 Inhibitor Raf inhibitor1 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.